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Non-invasive Reversible Software-based Configuration of a Clinically Used Linear Accelerator for Preclinical Electron FLASH Radiobiology
Stavros Melemenidis, Dixin Chen, Cody Jensen, Joseph B. Schulz, Murat Surucu, Amy S. Yu, Edward E. Graves, Mengying Shi, Michael Reilly, Peter G. Maxim, Andrew Currell, Billy W. Loo Jr, Lawrie Skinner, M. Ramish Ashraf
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Non-invasive Reversible Software-based Configuration of a Clinically Used Linear Accelerator for Preclinical Electron FLASH Radiobiology
Configuring clinical linear accelerators (linacs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware manipulation and/or irreversible manufacturer modifications, limiting broader implementation. We present an independently developed UHDR electron configuration of a clinical TrueBeam linac that allows reversible switching between preclinical UHDR and conventional (CONV) modes using only non-invasive software settings. UHDR mode was achieved via service mode…