Tootfinder

"Why Antidepressants Work Better for Some"
Key Facts:
Immune Pathways: Toll-like receptor and NF-κB pathways were consistently altered between responders and non-responders.
Neural Mechanisms: Signal transduction and GABAergic synapse pathways showed consistent changes with fluoxetine treatment.
Heterogeneity Noted: Patterns of gene expression varied across tissues, models, and individuals, emphasizing the need for larger, more targeted studies.
Paper: Sou…

Gene expression signatures of response to fluoxetine treatment: systematic review and meta-analyses - Molecular Psychiatry
Genomic (and other ‘omic) data have provided valuable insights on the pharmacological signatures of antidepressant response, but results from individual studies are largely heterogeneous. In this work, we synthesized gene expression data for fluoxetine treatment in both human patients and rodent models, to better understand biological pathways affected by treatment, as well as those that may distinguish clinical or behavioral response. Following the PRISMA guidelines, we searched the Gene Exp…

Notes on the topology of independence structures
Kevin Ivan Piterman, Volkmar Welker
https://arxiv.org/abs/2508.12971 https://arxiv.org/pdf/2508.12971

Notes on the topology of independence structures
Following Welsh, a pre-independence space (pi-space) is a set $M$ together with a non-empty collection $I(M)$ of subsets of $M$, called independent sets, which is closed under taking subsets, and finite independent sets satisfy the exchange property from matroid theory. We show that $I(M)$, viewed as a poset, is contractible if it is infinite-dimensional, and Cohen-Macaulay otherwise. Moreover, the proper part of the associated poset of flats is also contractible in the infinite-dimensional c…

"U.S. total consumption of fossil fuels is no longer falling. Importantly, it should be clarified this pattern was already emerging before Trump took office. Another reminder: Trump has only been in office for 8 months. So, the vast majority of changes to fossil fuel use and decarbonization are yet to come."
Slipping into Darkness - by Gregor Macdonald

Slipping into Darkness
Monday 18 August 2025

Happy #AutisticPrideDay! ♾️💙
I’m proudly autistic, my brain works in its own unique way, full of different thoughts and feelings all at once. Being autistic is part of who I am, not something to fix. 🧠🧠
I’m also queer and genderfluid, and that’s just another part of my colorful identity. Some days I feel one way, some days another, and that’s okay. 🏳️‍🌈☂️
Neurodiver…

I've got a 3am start with derpmaster Mike coming up in the next few days. He normally gets up at 5.30am so I've got a feeling there's going to be no settling him after I arrive and his regular humans all leave.
Still, hot weather will mean an early walk and breakfast and then we can both snooze!
My fourth year of looking after Michael.
#Greyhounds

I love the non-profit block of the Art Fair, I love to go and argue with the anti-tax people and the Mars society dweebs, to glare at the Republicans, to donate to Planned Parenthood and some of the off-brand religions, to smile and wave and loudly greet the communists HI COMMUNISTS!!! They always wave back. It is such a welcoming feeling!
I’ve been twice already today, once with four grandchildren who collected tons of swag and were cute as hell.

As data speeds increase, it has become crucial to detect problems as they happen. At this year's Berlin Buzzwords, Olena Kutsenko explained how to build a real-time anomaly detection system using Apache Kafka for streaming, Apache Flink for processing, and AI for pattern recognition, covering Apache Iceberg for storing historical data to improve models.
Watch the full session:

Automata Models for Effective Bug Description
Tom Yaacov, Gera Weiss, Gal Amram, Avi Hayoun
https://arxiv.org/abs/2507.11146 https://…

Automata Models for Effective Bug Description
Debugging complex systems is a crucial yet time-consuming task. This paper presents the use of automata learning and testing techniques to obtain concise and informative bug descriptions. We introduce the concepts of Failure Explanations (FE), Eventual Failure Explanations (EFE), and Early Detection (ED) to provide meaningful summaries of failing behavior patterns. By factoring out irrelevant information and focusing on essential test patterns, our approach aims to enhance bug detection and und…

Finding Some Impossibility of Flat-Folding of Given Origami Crease Pattern by Graphical Representation
Chihiro Nakajima
https://arxiv.org/abs/2506.12659 ht…

Finding Some Impossibility of Flat-Folding of Given Origami Crease Pattern by Graphical Representation
Flat-foldability problem of origami is the problem to determine whether a given crease pattern drawn on a piece of paper is possible to fold without any penetration or intrusion of a polygon into any connections among them. It is known from the results of Bern and Hayes and following studies that determining whether an origami diagram which constitute of polygons in general shapes can be flat-folded is an NP-hard problem. In this manuscript, on determining the flat foldability of unsigned creas…

Fronts and patterns with a dynamic parameter ramp
Montie Avery, Odalys Garcia-Lopez, Ryan Goh, Benjamin Hosek, Ethan Shade
https://arxiv.org/abs/2506.12142

Fronts and patterns with a dynamic parameter ramp
We examine the effect of a slowly-varying time-dependent parameter on invasion fronts for which an unstable homogeneous equilibrium is invaded by either another homogeneous state or a spatially periodic state. We first explain and motivate our approach by studying asymptotically constant invasion fronts in a scalar FKPP equation with time-dependent parameter which controls the stability of the trivial state. Following recent works in the area, we use a linearized analysis to derive formal predi…