@grumpybozo@toad.social2025-11-30 04:17:24
We’re at a point where these sorts of simple genetic disorders are going to be falling to CRISPR-Cas9 treatments one after another in an accelerating fashion until we run out of targets.
They raise troubling questions about access to care and cost. Ask why we still have people with active Sickle Cell disease, years after the CURE was demonstrated.
The reason is that no one is stepping up with the megabuck per patient. @…
@saraislet@infosec.exchange2025-10-28 09:11:21
I grew up with a lot of male cousins who loved watching sports. I understand that some people enjoy gambling for emotions, but I don't.
That's why I like books. Instead of gambling for feelings, a book takes my emotions on a journey, rips them to shreds in the middle in an unpredictable way, then grinds my feelings into a fine paste that they feed to their goat, which is sacrificed in a bloody feral ceremony whose carnage further defiles said emotional residue
Or you can …
@jake4480@c.im2025-12-27 03:48:58
Wow, it's the last #LetterboxdFriday of the year. Been doing some weird horror shorts. This year I surpassed 2,000 total films seen in my life, according to Letterboxd stats, and yeah, I probably have a problem. But at least I'm in my house watching weird movies and not out prowling the dark streets.
#Letterboxd
@lightweight@mastodon.nzoss.nz2025-12-24 02:02:28
Welp, after a day or two of fermentation and a few hours preparing the accompaniments, like the potato filling, the 'gunpowder' to sprinkle over it, and both tomato and coconut chutneys (all made from scratch, even involving cracking a fresh coconut!), I've made my first ever dosas. I'm quite chuffed by the result. It's a lot of work for a one-off...
@threeofus@mstdn.social2025-10-21 11:57:14
My brain is frazzled from all of the conflict. I feel like C is attacking me and accepting none of the responsibility for our predicament. I’ve tried to apologise for my shortcomings (failing to consult her on a decision I made about therapy for my son) but she’s thrown it back in my face telling me I’ve made the same mistakes before, and that she finds it hard to trust me. She says I take decisions unilaterally and don’t value her advice despite clear evidence to the contrary.
@benb@osintua.eu2025-12-10 17:21:48
Germany sends fighter jets to Poland: strengthening NATO's eastern flank #shorts: https://benborges.xyz/2025/12/10/germany-sends-fighter-jets-to.html
@teledyn@mstdn.ca2025-12-01 19:15:30
Found an obscure hint that perhaps instead of authenticating through #Evolution I should instead authenticate through the #Gnome settings for attached accounts, so I tried that approach, this time it asks for far more permissions (8 in all) but, you guessed it, a classic Sam Beckett "No Answer" and the terse response, "timed out".
So the app doesn't matter. The browser doesn't matter. The account or any legacy cruft doesn't matter.
Does this leave as the only explanation that perhaps Google no longer provides OAuth2 tokens? Surely that would be all over the news if true, but I'm running out of local culprits. Also Emacs inability to authenticate Mastodon suggests its neither google nor Debian per se? Maybe I should spend my time more productively slamming a car door on my fingers?
I have a dread feeling wiping the laptop and carefully reinstalling from scratch will not work.
@davidaugust@mastodon.online2025-10-08 21:41:45
Feckless felonious fool claims he “took the freedom of speech away” when it comes to flag burning. That’s not how this works you sanctimonious prick.
#USpol
@njamster@mastodon.gamedev.place2025-10-14 11:59:59
"Fixed Crust King Khann sometimes falling out of bounds during entry, when fought on low-end systems" must be the funniest patch note I've read in a while!
Imagine beating all 38 waves of the Coral Tower gauntlet (which, since you're playing on a low-end system, will likely lag and stutter) without finding the shortcut after the third arena, entering the boss arena and then... he just falls out of screen! 🤣
@stefan@gardenstate.social2025-12-05 12:47:16
I had not been following the news out of the Bennu asteroid but this is some very interesting stuff!
#space