Tootfinder

Quantifying Cross-Attention Interaction in Transformers for Interpreting TCR-pMHC Binding
Jiarui Li, Zixiang Yin, Haley Smith, Zhengming Ding, Samuel J. Landry, Ramgopal R. Mettu
https://arxiv.org/abs/2507.03197

Quantifying Cross-Attention Interaction in Transformers for Interpreting TCR-pMHC Binding
CD8+ "killer" T cells and CD4+ "helper" T cells play a central role in the adaptive immune system by recognizing antigens presented by Major Histocompatibility Complex (pMHC) molecules via T Cell Receptors (TCRs). Modeling binding between T cells and the pMHC complex is fundamental to understanding basic mechanisms of human immune response as well as in developing therapies. While transformer-based models such as TULIP have achieved impressive performance in this domain, their black-box nature …