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Optimizing information transmission in the canonical Wnt pathway
Olivier Witteveen, Samuel J. Rosen, Ryan S. Lach, Maxwell Z. Wilson, Marianne Bauer
https://arxiv.org/abs/2506.22633

Optimizing information transmission in the canonical Wnt pathway
Populations of cells regulate gene expression in response to external signals, but their ability to make reliable collective decisions is limited by both intrinsic noise in molecular signaling and variability between individual cells. In this work, we use optogenetic control of the canonical Wnt pathway as an example to study how reliably information about an external signal is transmitted to a population of cells, and determine an optimal encoding strategy to maximize information transmission …