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Unraveling the Redox Mechanisms Underlying FLASH Radiotherapy: Critical Dose Thresholds and NRF2-Driven Tissue Sparing
Yan Zhang, Chenyang Huang, Ankang Hu, Yucheng Wang, Yixun Zhu, Wanyi Zhou, Jiaqi Qiu, Jian Wang, Qibin Fu, Tuchen Huang, Hao Zha, Wei Wang, Junli Li
https://arxiv.org/abs/2508.20510

Unraveling the Redox Mechanisms Underlying FLASH Radiotherapy: Critical Dose Thresholds and NRF2-Driven Tissue Sparing
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing effect remain unclear, and mechanisms related to oxidative stress and redox regulation are poorly understood. This study utilizes a murine acute intestinal toxicity model to investigate how beam parameters influence the FLASH sparing effect and tumor control u…