Tootfinder

Bonus content on PEI's focus on disappearing farmland. The island isn't getting smaller, or bigger, but housing and industrial development are putting pressure on those potato fields.
#Farming
https://www.cbc.ca/news/canada/prince-edward-island/pei-news-farming-land-agriculture-1.6974633

Generative Data Refinement: Just Ask for Better Data
Minqi Jiang, Jo\~ao G. M. Ara\'ujo, Will Ellsworth, Sian Gooding, Edward Grefenstette
https://arxiv.org/abs/2509.08653 h…

Generative Data Refinement: Just Ask for Better Data
For a fixed parameter size, the capabilities of large models are primarily determined by the quality and quantity of its training data. Consequently, training datasets now grow faster than the rate at which new data is indexed on the web, leading to projected data exhaustion over the next decade. Much more data exists as user-generated content that is not publicly indexed, but incorporating such data comes with considerable risks, such as leaking private information and other undesirable conten…

Towards Scalable Proteomics: Opportunistic SMC Samplers on HTCondor
Matthew Carter, Lee Devlin, Alexander Philips, Edward Pyzer-Knapp, Paul Spirakis, Simon Maskell
https://arxiv.org/abs/2509.08020

Towards Scalable Proteomics: Opportunistic SMC Samplers on HTCondor
Quantitative proteomics plays a central role in uncovering regulatory mechanisms, identifying disease biomarkers, and guiding the development of precision therapies. These insights are often obtained through complex Bayesian models, whose inference procedures are computationally intensive, especially when applied at scale to biological datasets. This limits the accessibility of advanced modelling techniques needed to fully exploit proteomics data. Although Sequential Monte Carlo (SMC) methods o…

Detecting, intercepting, and ejecting adversaries is getting harder as cybercriminals move faster and smarter.
Check out my latest CSO piece on how CISOs need to rethink their digital playbooks in light of these trends.
Thanks to Matt Immler of Okta, Tom Etheridge of CrowdStrike and Pierre Cadieux of Cisco Talos for their insight.

CISOs must rethink defense playbooks as cybercriminals move faster, smarter
Facing faster, stealthier intruders, CISOs are under pressure to modernize their cybersecurity strategies, toolsets, and tactics. From detection to post-mortem, here are key points of renewed emphasis.

A Roadmap for Climate-Relevant Robotics Research
Alan Papalia, Charles Dawson, Laurentiu L. Anton, Norhan Magdy Bayomi, Bianca Champenois, Jung-Hoon Cho, Levi Cai, Joseph DelPreto, Kristen Edwards, Bilha-Catherine Githinji, Cameron Hickert, Vindula Jayawardana, Matthew Kramer, Shreyaa Raghavan, David Russell, Shide Salimi, Jingnan Shi, Soumya Sudhakar, Yanwei Wang, Shouyi Wang, Luca Carlone, Vijay Kumar, Daniela Rus, John E. Fernandez, Cathy Wu, George Kantor, Derek Young, Hanumant Sin…

A Roadmap for Climate-Relevant Robotics Research
Climate change is one of the defining challenges of the 21st century, and many in the robotics community are looking for ways to contribute. This paper presents a roadmap for climate-relevant robotics research, identifying high-impact opportunities for collaboration between roboticists and experts across climate domains such as energy, the built environment, transportation, industry, land use, and Earth sciences. These applications include problems such as energy systems optimization, construct…

One pocket to activate them all: Efforts on understanding the modulator pocket in K2P channels
Edward Mendez-Otalvaro, Wojciech Kopec, Marcus Schewe, Bert L. de Groot
https://arxiv.org/abs/2508.17891

One pocket to activate them all: Efforts on understanding the modulator pocket in K2P channels
The modulator pocket is a cryptic site discovered in the TREK1 K2P channel that accommodates agonists capable of increasing the channel's activity. Since its discovery, equivalent sites in other K2P channels have been shown to bind various ligands, both endogenous and exogenous. In this review, we attempt to elucidate how the modulator pocket contributes to K2P channel activation. To this end, we first describe the gating mechanisms reported in the literature and rationalize their modes of acti…