Tootfinder

Multi-omic Causal Discovery using Genotypes and Gene Expression
Stephen Asiedu, David Watson
https://arxiv.org/abs/2505.15866 https://

Multi-omic Causal Discovery using Genotypes and Gene Expression
Causal discovery in multi-omic datasets is crucial for understanding the bigger picture of gene regulatory mechanisms, but remains challenging due to high dimensionality, differentiation of direct from indirect relationships, and hidden confounders. We introduce GENESIS (GEne Network inference from Expression SIgnals and SNPs), a constraint-based algorithm that leverages the natural causal precedence of genotypes to infer ancestral relationships in transcriptomic data. Unlike traditional causal…