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Non-linear associations of amyloid-$\beta$ with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults
Junjie Wu, Benjamin B Risk, Taylor A James, Nicholas Seyfried, David W Loring, Felicia C Goldstein, Allan I Levey, James J Lah, Deqiang Qiu
https://arxiv.org/ab…

Non-linear associations of amyloid-$β$ with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults
Background: Non-linear alterations in brain network connectivity may represent early neural signatures of Alzheimer's disease (AD) pathology in cognitively normal older adults. Understanding these changes and their cognitive relevance could provide sensitive biomarkers for early detection. Most prior studies recruited participants from memory clinics, often with subjective memory concerns, limiting generalizability. Methods: We examined 14 large-scale functional brain networks in 968 cognitiv…

“My guess is he is getting Kisunla treatments, a monoclonal antibody drug given by monthly infusions to remove amyloid plaques from his brain. It is given to people with signs of Alzheimer’s who have a family history or other risk factors."
'I Was Thinking the Same Thing!': Trump’s Vanishing Acts Keep Lining Up Too Perfectly—Now the Internet’s Convinced They Know What He’s Been Up To
https://atlantablackstar.com/2025/10/06/trumps-vanishing-acts-keep-lining-up-too-perfectlynow-the-internets-convinced-they-know-what-happens-every-28-days/

Pyk2 plays a critical role in synaptic dysfunction during the early stages of Alzheimer's disease
Quentin Rodriguez (GIN, UGA), Floriane Payet (GIN, UGA), Karina Vargas-Baron (GIN, UGA), Eve Borel (GIN, UGA), Fabien Lant\'e (GIN, UGA), Sylvie Boisseau (GIN, UGA), B\'eatrice Blot (GIN, UGA), Jean-Antoine Girault (IFM - Inserm U1270 - SU, INSERM), Alain Buisson (GIN, UGA)

Pyk2 plays a critical role in synaptic dysfunction during the early stages of Alzheimer's disease
Background: The locus of the gene PTK2B encoding the tyrosine kinase Pyk2 has been associated with the risk of late-onset Alzheimer's disease, the predominant form of dementia. Pyk2 is primarily expressed in neurons where it is involved in excitatory neurotransmission and synaptic functions. Although previous studies have implicated Pyk2 in amyloid-$β$ and Tau pathologies of Alzheimer's disease, its exact role remains unresolved, with evidence showing both detrimental and protective effects in…

Alzheimer's Clinical Research Data via R Packages: the alzverse
Michael C. Donohue (for the Alzheimer's Disease Neuroimaging Initiative), Kedir Hussen (for the Alzheimer's Disease Neuroimaging Initiative), Oliver Langford (for the Alzheimer's Disease Neuroimaging Initiative), Richard Gallardo (for the Alzheimer's Disease Neuroimaging Initiative), Gustavo Jimenez-Maggiora (for the Alzheimer's Disease Neuroimaging Initiative), Paul S. Aisen (for the Alzheimer'…

Alzheimer's Clinical Research Data via R Packages: the alzverse
Sharing clinical research data is essential for advancing research in Alzheimer's disease (AD) and other therapeutic areas. However, challenges in data accessibility, standardization, documentation, usability, and reproducibility continue to impede this goal. In this article, we highlight the advantages of using R packages to overcome these challenges using two examples. The A4LEARN R package includes data from a randomized trial (the Anti-Amyloid Treatment in Asymptomatic Alzheimer's [A4] stud…