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Repulsive particle interactions enable selective information processing at cellular interfaces
Jenna Elliott, Hiral Shah, Roman Belousov, Gautam Dey, Anna Erzberger
https://arxiv.org/abs/2506.14739

Repulsive particle interactions enable selective information processing at cellular interfaces
Living systems relay information across membrane interfaces to coordinate compartment functions. We identify a physical mechanism for selective information transmission that arises from the sigmoidal response of surface-bound particle densities to spatial features of adjacent external structures. This mechanism implements a form of spatial thresholding, enabling the binary classification of external cues. Expansion microscopy measurements of nuclear pore complex distributions in S. arctica show…