Tootfinder

Antibody Consumption-Driven Dynamic Competition: A Systems Hypothesis for the Transition from Acute Immune Response to Post-Infection Sequelae
Shi Qiru
https://arxiv.org/abs/2506.06413

Antibody Consumption-Driven Dynamic Competition: A Systems Hypothesis for the Transition from Acute Immune Response to Post-Infection Sequelae
The mechanisms underlying the formation of post-infection sequelae are complex and remain controversial. This hypothesis integrates Bystryn's antibody feedback phenomenon and Imbiakha's immune cost theory, proposing for the first time a "Consumption-Driven Dynamic Competition of Antibody Clones" mechanism. This mechanism posits that the immune system may regulate the proliferation and differentiation of corresponding B cell clones by sensing and responding to the consumption rate of specific an…

X-ray Polarization Detection of the Pulsar Wind Nebula in G21.5-0.9 with IXPE
Niccol\`o Di Lalla, Nicola Omodei, Niccol\`o Bucciantini, Jack T. Dinsmore, Nicol\`o Cibrario, Stefano Silvestri, Josephine Wong, Patrick Slane, Tsunefumi Mizuno, Michela Negro, Roger W. Romani, Riccardo Ferrazzoli, Stephen Chi-Yung Ng, Miltiadis Michailidis, Yi-Jung Yang, Fei Xie, Martin C. Weisskopf, Philip Kaaret, Iv\'an Agudo, L. A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronal…

X-ray Polarization Detection of the Pulsar Wind Nebula in G21.5-0.9 with IXPE
We present the X-ray polarization observation of G21.5-0.9, a young Galactic supernova remnant (SNR), conducted with the Imaging X-ray Polarimetry Explorer (IXPE) in October 2023, with a total livetime of approximately 837 ks. Using different analysis methods, such as a space-integrated study of the entire region of the PWN and a space-resolved polarization map, we detect significant polarization from the pulsar wind nebula (PWN) at the center of the SNR, with an average polarization degree of …

Improving Regulatory Oversight in Online Content Moderation
Benedetta Tessa, Denise Amram, Anna Monreale, Stefano Cresci
https://arxiv.org/abs/2506.04145 h…

Improving Regulatory Oversight in Online Content Moderation
The European Union introduced the Digital Services Act (DSA) to address the risks associated with digital platforms and promote a safer online environment. However, despite the potential of components such as the Transparency Database, Transparency Reports, and Article 40 of the DSA to improve platform transparency, significant challenges remain. These include data inconsistencies and a lack of detailed information, which hinder transparency in content moderation practices. Additionally, the ab…

uspolitics, trump
I keep seeing smart people writing stuff like
> [the US] kept peace through strength balanced with restraint, and wielded influence through culture, values, and diplomacy
I understand that #Trump is terrible and some people feel tempted to idealize what they had before him, but we should be more discerning, or otherwise it becomes impossible to understand how this happened in the first place.
Let's start with some questions:
- peace where? and for who? was it true peace, or "Pax Romana"?
- are we going to take seriously that statement on "restraint"? after all the lies, internal witch hunting, sanctions, coups, wars, invasions, genocides, and last but not least, 2 unnecessary nuclear strikes on Japan?
Now, on "culture, values, and diplomacy". Sure. Why not. Not everything was going to be bad, right?
But the thing is, abusive husbands aren't bad all the time either. From time to time they know how to be sweet and seem to care: one present here, flowers the next day, a little bit of gaslighting, and fake apologies after that "accidental" slap.
Given enough time (if the wife is still alive), at some point the victim decides to leave, and then all hell breaks loose. Trump is the manifestation of that moment. He does not represent a change in #USA's nature, but a hidden side that was "always" there, just waiting to play its role.
Others believe this is because #US citizens have been intentionally dumbed down by a combination of propaganda and a disfunctional education system, and I'm sure it's partly true... But let's see what many of their most brilliant and educated citizens are choosing to do with their lives today: https://sfstandard.com/2025/03/12/stanford-students-want-in-on-the-military-tech-gold-rush/
So, all I'm asking is: please drop the act. It was always a clusterfuck.

“Under a 287(g) task force model, such as the agreement being pursued by the University of Florida, participating officers would have the authority to interrogate “any alien or person believed to be an alien” about their right to remain in the country, as well as the power to make arrests without a warrant in some cases.”
https://www.wuft.org/public-safety/2025-04-14/uf-other-florida-universities-to-deputize-campus-police-for-immigration-enforcement
Imagine being asked to learn while you can be stopped and interrogated just walking between classes because a campus police officer believes you might not be a US citizen.

Topological Machine Learning for Protein-Nucleic Acid Binding Affinity Changes Upon Mutation
Xiang Liu, Junjie Wee, Guo-Wei Wei
https://arxiv.org/abs/2505.22786

Topological Machine Learning for Protein-Nucleic Acid Binding Affinity Changes Upon Mutation
Understanding how protein mutations affect protein-nucleic acid binding is critical for unraveling disease mechanisms and advancing therapies. Current experimental approaches are laborious, and computational methods remain limited in accuracy. To address this challenge, we propose a novel topological machine learning model (TopoML) combining persistent Laplacian (from topological data analysis) with multi-perspective features: physicochemical properties, topological structures, and protein Tran…

Genetic Influences on Brain Aging: Analyzing Sex Differences in the UK Biobank using Structural MRI
Karen Ardila, Aashka Mohite, Abdoljalil Addeh, Amanda V. Tyndall, Cindy K. Barha, Quan Long, M. Ethan MacDonald
https://arxiv.org/abs/2505.20344

Genetic Influences on Brain Aging: Analyzing Sex Differences in the UK Biobank using Structural MRI
Brain aging trajectories differ between males and females, yet the genetic factors underlying these differences remain underexplored. Using structural MRI and genotyping data from 40,940 UK Biobank participants (aged 45-83), we computed Brain Age Gap Estimates (BrainAGE) for total brain, hippocampal, and ventricular volumes. We conducted sex-stratified genome-wide association studies (GWAS) and Post-GWAS analyses to identify genetic variants associated with accelerated brain aging. Distinct gen…