Tootfinder

This is the most detailed picture of a human cell ever made 🧪
https://www.instagram.com/reel/DX1CGIZMKJs/?igsh=NTc4MTIwNjQ2YQ

Sam Bousaba on Instagram: "This is a single human cell. The white filament-like structures are microtubules, and the small colored particles are ribosomes. Your body contains on the order of ~37 trillion cells. Each cell functions like a highly organized, self-regulating factory operating continuously. There is no central “supervisor”—yet thousands of processes run in parallel with remarkable coordination. Every ribosome is constantly building proteins by linking amino acids together. In eukaryotic (human) cells, a ribosome typically adds about 5–10 amino acids per second (not ~20). Since a single cell can contain millions of ribosomes, protein production is massive—resulting in millions to tens of millions of peptide bonds formed per second per cell. The microtubules act as an internal transport network. Motor proteins such as kinesin move along these tracks, carrying cellular cargo. They “walk” step by step using ATP, at speeds of roughly 500–1000 nanometers per second. Each cell contains a dense network of these filaments, with many motor proteins moving simultaneously. Just beneath the cell membrane lies the actin cortex, a dynamic meshwork that helps maintain cell shape and resist mechanical stress. This structure is continuously remodeled—assembled and disassembled—allowing the cell to adapt to its environment. Now scale this up. Across ~37 trillion cells, each containing millions of ribosomes and hundreds to thousands of mitochondria, your body is constantly producing energy in the form of ATP. Total ATP turnover is enormous—roughly equivalent to your body weight in ATP recycled every day. The DNA in a single human cell, if stretched out, measures about 2 meters. Across all your cells, this would span distances comparable to traveling from Earth to the Sun and back many times (the exact multiple depends on assumptions about cell count and DNA packing). None of these processes are under conscious control. They began when you were a single cell and have continued uninterrupted ever since."
62K likes, 2,387 comments - scienceoftheuniverse on May 2, 2026: "This is a single human cell. The white filament-like structures are microtubules, and the small colored particles are ribosomes. Your body contains on the order of ~37 trillion cells. Each cell functions like a highly organized, self-regulating factory operating continuously. There is no central “supervisor”—yet thousands of processes run in parallel with remarkable coordination. Every ribosome is constantly building prot…

Since it was relevant to a discussion I just had on here and is something most people probably haven't thought about much (unless you've taken one of a handful of philosophy classes), I thought I'd try to lay out a key piece of Descartes' Meditations (#philosophy

From Licensing to Open Access: Designing a Sustainable Transition in Operational Weather Data
Emma Pidduck, Umberto Modigliani, Victoria L. Bennett, Fabio Venuti, Florian Pappenberger, Florence Rabier
https://arxiv.org/abs/2605.21673 https://arxiv.org/pdf/2605.21673 https://arxiv.org/html/2605.21673
arXiv:2605.21673v1 Announce Type: new
Abstract: This translational article documents the European Centre for Medium-Range Weather Forecasts (ECMWF) transition from a restricted data licensing model to open access under CC BY 4.0, completed in October 2025. The policy context included EU open data requirements and alignment with international data exchange frameworks. The transition was implemented through a tiered service model that kept core forecast data open while offering operationally supported delivery as a cost-recovered service. Between 2020 and 2025, ECMWF executed an iterative planning cycle: setting an annual target for revenue reduction, specifying additions to the open tier under that target, provisioning infrastructure, and assessing outcomes to update assumptions. Drawing on internal administrative records (2014 - 2025), we describe design choices, operational constraints, and early outcomes. In the six months following the end of the transition, more than 93% of previously paying organisations retained a Service Agreement, while open endpoint download volumes increased substantially. We discuss trade-offs in defining the open tier (resolution, parameters, schedule), the reduction of compliance overheads formerly associated with redistribution restrictions, and the scalability implications of global distribution. We note an emerging sustainability question as AI-based forecast products become freely available. The early evidence is consistent with the view that a tiered service model can be designed to reconcile open-access obligations with operational sustainability, subject to monitoring over longer contract renewal cycles (typically annual).
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Springer-Nature sells Scienterrific American
"We should call this action what it is – blatant union-busting. But there’s worse: we also have reason to believe that the sale was motivated by fear within Springer Nature that our attempts to doggedly report on the crisis facing science in America today would lead to repercussions from the Trump administration. On multiple occasions the company has sought to quash or tone down political or sensitive stories that were journalistically sound.
"We are calling on our new owners to immediately recognize our unit and meet us at the bargaining table to work together to steer a sustainable future of Scientific American–including, but going far beyond, a commitment to respecting our editorial independence.  We have already developed a number of proposals for making our journalism more profitable that we look forward to discussing in these negotiations."
https://www.tumblr.com/dduane/820330200182226944/wgae-scientific-american-union-statement-on?source=share

Perfection Because It Doesn’t Exist 🎐
完美因为完美不存在 🎐
📷 Nikon F4E
🎞️ Kentmere 400
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Wise

Two Brunettes & A Gay
Indulge in an hour of witty banter and lively discussions with these cheeky 30-somethings, along with special guests from the entertainment industry and beyond...
Great Australian Pods Podcast Directory: https://www.greataustralianpods.com/two-br…

Build-Authorized Evidence for Opaque Calls: A Fail-Closed Rewrite-Authority Boundary
Zhonghua Yi (Toka Language Research Group)
https://arxiv.org/abs/2607.18949 https://arxiv.org/pdf/2607.18949 https://arxiv.org/html/2607.18949
arXiv:2607.18949v1 Announce Type: new
Abstract: Detached semantic facts about opaque native providers do not by themselves justify compiler rewrites: rewrite authority must be confined to the accepted fact, selected provider and build, caller, callback environment, observation, and runtime target. We present a build-authorized path-effect interface that enforces this boundary through fail-closed authorization and link receipts. The design separates receipt closure, callback-environment closure, and projection identity, and passes accepted facts to LLVM through a narrow internal API. We use one-hop topology-load reuse as a minimal observable witness of authority, not as the optimization target.
A conservative LLVM consumer reuses a pointer observation only from a noalias root or one constant nonzero projection. Rocq models prove conditional refinement and authority non-amplification under explicit effect, alias, compiler/ABI, and target-resolution premises. We instantiate checked production with Toka: a source-summary gate emits exact LLVM IR, a separate IR checker accepts only a bounded topology-preserving subset, and only accepted IR is compiled into the receipt-bound provider object. A bounded static Darwin/arm64 profile also checks the final direct branch target.
Across issuer-declared readv, recvmsg, and Cairo boundaries, authorized IR retains each opaque call, reduces the relevant loads from two to one, and preserves observed results; mismatched providers, builds, callbacks, projections, and unsupported IR remain neutral. A libjpeg case is rejected because its callback environment is open, while a bound callback singleton demonstrates the supported closure rule. The contribution is a checked deployment-compiler boundary with an explicit trust and applicability frontier, not a uniquely expressive effect encoding or a new load-elimination algorithm.
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Same Place 🐲
同一個地方 🐲
📷 Nikon F4E
🎞️ Kentmere 400
If you like my work, Support by buying me a coffee or a roll of film from
PayPal https://www.paypal.com/paypalme/ydcdingsite
Wise

From Licensing to Open Access: Designing a Sustainable Transition in Operational Weather Data
Emma Pidduck, Umberto Modigliani, Victoria L. Bennett, Fabio Venuti, Florian Pappenberger, Florence Rabier
https://arxiv.org/abs/2605.21673

City Silhouettes V🏙️
城市轮廓线 V 🏙️
📷 Pentax 6x7
🎞️ Kentmere 400 (6x7)
If you like my work, Support by buying me a coffee or a roll of film from PayPal https://www.paypal.com/paypalme/ydcdingsite