Tootfinder

Diversity by Design: Addressing Mode Collapse Improves scRNA-seq Perturbation Modeling on Well-Calibrated Metrics
Gabriel M. Mejia, Henry E. Miller, Francis J. A. Leblanc, Bo Wang, Brendan Swain, Lucas Paulo de Lima Camillo
https://arxiv.org/abs/2506.22641

Diversity by Design: Addressing Mode Collapse Improves scRNA-seq Perturbation Modeling on Well-Calibrated Metrics
Recent benchmarks reveal that models for single-cell perturbation response are often outperformed by simply predicting the dataset mean. We trace this anomaly to a metric artifact: control-referenced deltas and unweighted error metrics reward mode collapse whenever the control is biased or the biological signal is sparse. Large-scale \textit{in silico} simulations and analysis of two real-world perturbation datasets confirm that shared reference shifts, not genuine biological change, drives hig…

Testing Paradox May Explain Increased Observed Prevalence of Bacterial STIs among MSM on HIV PrEP: A Modeling Study
Laura M\"uller, Piklu Mallick, Antonio B. Mar\'in-Carballo, Philipp D\"onges, Robyn J. N. Kettlitz, Carolina J. Klett-Tammen, Mirjam Kretzschmar, Viola Priesemann, Seba Contreras
https://arxiv.org/abs…

Testing Paradox May Explain Increased Observed Prevalence of Bacterial STIs among MSM on HIV PrEP: A Modeling Study
HIV pre-exposure Prophylaxis (PrEP) has become essential for global HIV control, but its implementation coincides with rising bacterial STI rates among men who have sex with men (MSM). While risk-compensation behavioral changes like reduced condom use are frequently reported, we examine whether intensified asymptomatic screening in PrEP programs creates surveillance artifacts that could be misinterpreted. We developed a compartmental model to represent the simultaneous spread of HIV and chlamyd…

Days after Health Secretary Robert F. Kennedy Jr. announced that Covid shots would be removed from the federal immunization schedule for children,
the Centers for Disease Control and Prevention issued updated advice that largely countered Mr. Kennedy’s new policy.
The agency kept Covid shots on the schedule for healthy children 6 months to 17 years old, -- but added a new condition.
Children and their caregivers will be able to get the vaccines in consultation with a doctor…

CDC Issues New Advice on Covid Vaccines for Children That Contradicted RFK Jr.
Health Secretary Robert F. Kennedy Jr. said on Tuesday that the vaccine would no longer appear on the childhood immunization schedule. C.D.C.’s update counters his policy.

Tried Wayland Plasma 6 on openSUSE on a ThinkPad P14s G5 AMD last night:
-Firefox doesn't render properly
-TrackPoint is nearly unusably twitchy and doesn't respond to speed/acceleration settings
-Input latency makes it difficult to control the mouse pointer accurately
That was enough for me to log out and return to an X session. Once they finish deleting X11 from all distros and removing any X support from modern DEs, I guess I'll just get a Mac. We had a …

Bei der Logitech MX Master 3 ist die Daumentaste "Maustaste 6" unter macOS und kann als solche in den Systemeinstellungen bei Schreibtisch & Dock als Mauskurzbefehl für Mission Control hinterlegt werden.
Ich hatte kurz Sorge, ich müsse Logitech Software installieren, um das zu konfigurieren.

UN Secretary-General Antonio Guterres said.
“This is a dangerous escalation in a region already on the edge – and a direct threat to international peace and security”, he said, adding that there is a “growing risk” that this conflict could “rapidly get out of control – with catastrophic consequences for civilians, the region, and the world”.
World reacts to US attacks on Iran | Israel-Iran conflict News | Al Jazeera

World reacts to US attacks on Iran
A roundup of reactions as US joins Israel’s war and attacks three Iranian nuclear sites.

Effect of Vaccine Dose Intervals: Considering Immunity Levels, Vaccine Efficacy, and Strain Variants for Disease Control Strategy
Samiran Ghosh, Malay Banerjee, Amit K Chattopadhyay
https://arxiv.org/abs/2505.21132

Effect of Vaccine Dose Intervals: Considering Immunity Levels, Vaccine Efficacy, and Strain Variants for Disease Control Strategy
In this study, we present an immuno-epidemic model to understand mitigation options during an epidemic break. The model incorporates comorbidity and multiple-vaccine doses through a system of coupled integro-differential equations to analyze the epidemic rate and intensity from a knowledge of the basic reproduction number and time-distributed rate functions. Our modeling results show that the interval between vaccine doses is a key control parameter that can be tuned to significantly influence …

Innovative Adaptive Imaged Based Visual Servoing Control of 6 DoFs Industrial Robot Manipulators
Rongfei Li, Francis Assadian
https://arxiv.org/abs/2506.10240

Innovative Adaptive Imaged Based Visual Servoing Control of 6 DoFs Industrial Robot Manipulators
Image-based visual servoing (IBVS) methods have been well developed and used in many applications, especially in pose (position and orientation) alignment. However, most research papers focused on developing control solutions when 3D point features can be detected inside the field of view. This work proposes an innovative feedforward-feedback adaptive control algorithm structure with the Youla Parameterization method. A designed feature estimation loop ensures stable and fast motion control whe…

Day 8
TL;DR: Yesterday I took a break. Today I’m back – and permissions are under control :)
Spent the day designing a fine-grained permission model.
I now support 96 distinct permissions across 8 modules, 4 CRUD operations, and 3 scopes: self, group, global.
Three system roles bind these into meaningful sets:
admin: full global access (32 permissions)
supervisor: read self full group scope (32)
employee: read/update self only (16)
That's 80 rol…

Day#8 📊 Designing a Scalable Permission Model
Yesterday I took a break. Today I’m back – and permissions are under control, I hope. I’ve implemented a structured permission model tha...

Yesterday Trump told us that his plan was to remove 21m people from the United States,
or 6% of our current population and at least 5% of our total current workforce.
“All of them have to go home.”
A few points about this insane post:
Best estimates are that the total undocumented population in the US is between 12m and 15m.
The figure that Trump and his regime keeps using
- 21m came in under Biden
- is made up and false.
Here’s the latest Pe…

Trump's Escalating Migrant Terror Campaign Is Unpopular, Out Of Control, Inhumane And Doing Enormous Harm To The Country
Leon Krauze, long time Los Angeles Univision anchor, joins us Live at 12:15pm ET today

A Novel Feedforward Youla Parameterization Method for Avoiding Local Minima in Stereo Image Based Visual Servoing Control
Rongfei Li, Francis Assadian
https://arxiv.org/abs/2506.10252

A Novel Feedforward Youla Parameterization Method for Avoiding Local Minima in Stereo Image Based Visual Servoing Control
In robot navigation and manipulation, accurately determining the camera's pose relative to the environment is crucial for effective task execution. In this paper, we systematically prove that this problem corresponds to the Perspective-3-Point (P3P) formulation, where exactly three known 3D points and their corresponding 2D image projections are used to estimate the pose of a stereo camera. In image-based visual servoing (IBVS) control, the system becomes overdetermined, as the 6 degrees of fre…

Day 5
TL;DR: Continued work on backend security — role-based access is now fully wired up.
✅ Got fine-grained role-based access control fully working today.
• Roles loaded from PostgreSQL
• Injected into JWT during login
• Validated via custom `@Roles()` `RolesGuard`
• Authenticated via `@UseGuards(JwtAuthGuard)` globally
• Introduced `@Public()` decorator to bypass guards for public endpoints
• Swagger supports Bearer token for testing …

Continuation: Securing Routes with JWT and Role-Based Access Control
TL;DR: Continuing development on the backend platform — this time focusing on securing routes with JWT, implementing @Roles decorators, h...

Invasive species control via a discrete model for the Trojan Y-chromosome strategy
Don K. Mallawa Arachchi, Rana D. Parshad, Claus Kadelka
https://arxiv.org/abs/2506.14023

Invasive species control via a discrete model for the Trojan Y-chromosome strategy
Invasive species are a growing threat to ecosystems, particularly in aquatic environments. The Trojan Y Chromosome (TYC) strategy is a promising biological method for reducing invasive populations by introducing genetically modified males (supermales) that produce only male offspring, leading to population decline due to a shortage of females. In this study, we develop a novel discrete--time, age--structured mathematical model to simulate the effects of this strategy. Our model divides the life…

Strain-tuning for superconductivity in La$_3$Ni$_2$O$_7$ thin films
Motoki Osada, Chieko Terakura, Akiko Kikkawa, Masamichi Nakajima, Hsiao-Yi Chen, Yusuke Nomura, Yoshinori Tokura, Atsushi Tsukazaki
https://arxiv.org/abs/2506.15319

Strain-tuning for superconductivity in La$_3$Ni$_2$O$_7$ thin films
The recent discovery of high-transition temperature ($T_\mathrm{c}$) superconductivity in pressurized La$_{3}$Ni$_{2}$O$_{7}$ bulk crystals has attracted keen attention due to its characteristic energy diagram of $e_{g}$ orbitals, containing nearly half-filled $d_{3z^2 - r^2}$ and quarter-filled $d_{x^2 - y^2}$ orbitals. This finding provides valuable insights into the orbital contributions and interlayer interactions in double NiO$_{6}$ octahedra, offering opportunities to control the electron…

Impact of the WHO's 90-70-90 Strategy on HPV-Related Cervical Cancer Control: A Mathematical Model Evaluation in China
Hua Liu, Chunya Liu, Yumei Wei, Qibin Zhang, Jingyan Ma
https://arxiv.org/abs/2506.06405

Impact of the WHO's 90-70-90 Strategy on HPV-Related Cervical Cancer Control: A Mathematical Model Evaluation in China
In August 2020, the World Health Assembly approved the Global Strategy to eliminate cervical cancer, marking the first time that numerous countries committed to eliminating a form of cancer. China introduced the HPV vaccine in 2016 and has made significant advancements in both prevention and treatment strategies. However, due to the relatively late introduction of the vaccine, the burden of cervical cancer in China continues to rise. In light of this, we develop a compartmental model to assess …

Heat Dissipation and Thermoelectric Performance of InSe-Based Monolayers: A Monte Carlo Simulation Study
Seyedeh Ameneh Bahadori, Zahra Shomali, Reza Asgari
https://arxiv.org/abs/2506.08212

Heat Dissipation and Thermoelectric Performance of InSe-Based Monolayers: A Monte Carlo Simulation Study
Using nonequilibrium Monte Carlo simulations of the phonon Boltzmann transport equation, we study transient heat transfer in five indium-based two-dimensional monolayers: Janus monolayers In$_2$SeTe and In$_2$SSe, pristine InSe, and InSe under 4$\%$ and 6$\%$ tensile strain. In this work, the potential of these materials for energy conversion in thermoelectric generators and hotspot control in metal-oxide-semiconductor field-effect transistors is investigated. A promising option for an effectiv…