Tootfinder

Immer, wenn ich was über CRISPR/Cas lese, muss ich an den FDP-Politiker denken, der 1989 in der Bundesrepublik Außenminister war.

This https://arxiv.org/abs/2201.01879 has been replaced.
link: https://scholar.google.com/scholar?q=a

Exponential family measurement error models for single-cell CRISPR screens
CRISPR genome engineering and single-cell RNA sequencing have accelerated biological discovery. Single-cell CRISPR screens unite these two technologies, linking genetic perturbations in individual cells to changes in gene expression and illuminating regulatory networks underlying diseases. Despite their promise, single-cell CRISPR screens present substantial statistical challenges. We demonstrate through theoretical and real data analyses that a standard method for estimation and inference in s…

Transforming #Cancer Treatment: #CRISPR Technology Unveils a New Path
https://

Transforming Cancer Treatment: CRISPR Technology Unveils a New Path
New technology using CRISPR to enhance the immune system's ability to detect cancer cells has been created, potentially paving the way for innovative cancer treatment methods. Major histocompatibility complex (MHC) class I molecules are an immune complex present on the surface of all cells in hum

CRISPR: Ensemble Model
Mohammad Rostami, Amin Ghariyazi, Hamed Dashti, Mohammad Hossein Rohban, Hamid R. Rabiee
https://arxiv.org/abs/2403.03018 https://…

CRISPR: Ensemble Model
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a gene editing technology that has revolutionized the fields of biology and medicine. However, one of the challenges of using CRISPR is predicting the on-target efficacy and off-target sensitivity of single-guide RNAs (sgRNAs). This is because most existing methods are trained on separate datasets with different genes and cells, which limits their generalizability. In this paper, we propose a novel ensemble learning method fo…

Bij mijn lief, Huisgenoot H., is dit in haar jeugd met harde hand in haar dna ge-CRISPR-cast en ik denk niet dat ze hiervan ooit gaat herstellen.

Yay 🙌 🔬 HIV cure breakthrough as virus eliminated from cells in laboratory
It is thanks to a gene-editing tool known as Crispr-Cas, which won the Nobel Prize in 2020
https://www.independent.co.uk/news/health/hiv-cure-cell-test-dna-b2515169.html<…

HIV cure breakthrough as virus eliminated from cells in laboratory
It is thanks to a gene-editing tool known as Crispr-Cas, which won the Nobel Prize in 2020

#Gentechnik in der Landwirtschaft in der EU verschoben
#crispr
https://www.

Gentechnik in der Landwirtschaft verschoben
Bei den Grünen knallen die Korken: Das umstrittene europäische Gentechnik-Gesetz muss verschoben werden, den

We started a project 5 years ago. Knocked down a protein with siRNA. Saw a phenotype, and rescueed it with ectopic transfection of the protein. Reviewer comment was: Repeat using CRISPR. And I don't understand how this is a valid scientific criticism.

As the world prepares for future and ongoing global health threats from RNA viruses such as the SARS-CoV-2 pandemic,
breakthrough advances in antiviral development are becoming a critical weapon in the fight against these infectious diseases.
At the heart of this innovation is the exploration of CRISPR/Cas13 systems,
which are known for their programmable capabilities to manipulate RNAs and have become indispensable tools for various RNA targeting applications.
Howeve…

Cas13d-NCS: A game-changer in RNA virus defense
The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate.

Yogurt drink instead of a colonoscopy? CRISPR bacteria are tested
https://www.statnews.com/2023/08/10/colon-cancer-test-engineered-bacteria/

A yogurt drink instead of a colonoscopy? Study uses engineered bacteria to detect cancer
Using yogurt to replace a colonoscopy may sound far-fetched, but scientists just showed that bacteria can be engineered to detect cancerous DNA.

Season combinatorial intervention predictions with Salt & Peper
Thomas Gaudelet, Alice Del Vecchio, Eli M Carrami, Juliana Cudini, Chantriolnt-Andreas Kapourani, Caroline Uhler, Lindsay Edwards
https://arxiv.org/abs/2404.16907

Season combinatorial intervention predictions with Salt & Peper
Interventions play a pivotal role in the study of complex biological systems. In drug discovery, genetic interventions (such as CRISPR base editing) have become central to both identifying potential therapeutic targets and understanding a drug's mechanism of action. With the advancement of CRISPR and the proliferation of genome-scale analyses such as transcriptomics, a new challenge is to navigate the vast combinatorial space of concurrent genetic interventions. Addressing this, our work concen…