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Principles of Physiological Closed-Loop Controllers in Neuromodulation
Victoria S. Marks, Joram vanRheede, Dean Karantonis, Rosana Esteller, David Dinsmoor, John Fleming, Barrett Larson, Lane Desborough, Peter Single, Robert Raike, Pierre-Francois DHaese, Dario J. Englot, Scott Lempka, Richard North, Lawrence Poree, Marom Bikson, Tim J. Denison
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Principles of Physiological Closed-Loop Controllers in Neuromodulation
As neurostimulation devices increasingly incorporate closed-loop functionality, the greater design complexity brings additional requirements for risk management and special considerations to optimise benefit. This manuscript creates a common framework upon which all current and planned neuromodulation-based physiological closed-loop controllers (PCLCs) can be mapped including integration of the Technical Considerations of Medical Devices with Physiologic Closed-Loop Control Technology guidance …