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From shallow to full wrapping: geometry and deformability dictate lipid vesicle internalization
Stijn van der Ham, Alexander Brown, Halim Kusumaatmaja, Hanumantha Rao Vutukuri
https://arxiv.org/abs/2507.17434

From shallow to full wrapping: geometry and deformability dictate lipid vesicle internalization
The deformability of vesicles critically influences their engulfment by lipid membranes, a process central to endocytosis, viral entry, drug delivery, and intercellular transport. While theoretical models have long predicted this influence, direct experimental validation has remained elusive. Here, we combine experiments with continuum simulations to quantify how vesicle deformability affects the engulfment of small giant unilamellar vesicles (GUVs) by larger GUVs under depletion-induced adhesi…