Tootfinder

The Epigenetic Tapestry: A Review of DNA Methylation and Non-Coding RNA's Interplay with Genetic Threads, Weaving a Network Impacting Gene Expression and Disease Manifestations
Yu-Li He, Youshin Loh
https://arxiv.org/abs/2510.06781

The Epigenetic Tapestry: A Review of DNA Methylation and Non-Coding RNA's Interplay with Genetic Threads, Weaving a Network Impacting Gene Expression and Disease Manifestations
The emerging field of epigenetics has recently unveiled a dynamic landscape in which gene expression is not determined solely by genetic sequences but also by intricate regulatory mechanisms. This review examines the interactions between these regulatory mechanisms, including DNA methylation and non-coding RNAs (ncRNAs), that orchestrate gene expression fine-tuning for cellular homeostasis and the pathogenesis of a multitude of diseases. We explore long non-coding RNAs (lncRNAs) such as telomer…

Aggregating Epigenetic Clocks to Study Human Capital Formation
Giorgia Menta, Pietro Biroli, Divya Mehta, Conchita D'Ambrosio, Deborah Cobb-Clark
https://arxiv.org/abs/2509.14422

Aggregating Epigenetic Clocks to Study Human Capital Formation
Epigenetics is the study of how people's behavior and environments influence the way their genes are expressed, even though their DNA sequence is itself unchanged. By aggregating age-related epigenetic markers, epigenetic 'clocks' have become the leading tool for studying biological aging. We make an important contribution by developing a novel, integrated measure of epigenetic aging--the Multi EpiGenetic Age (MEGA) clock--which combines several existing epigenetic clocks to reduce measurement …