Integrative neurocybernetic modeling in the era of large-scale neuroscience
Il Memming Park, Ayesha Vermani, Gonzalo G. de Polavieja, Juan \'Alvaro Gallego, Kathleen Esfahany, Shreya Saxena, Michael Orger, Auke Ijspeert, Matthew Dowling, Daniel McNamee, Srinivas C. Turaga, Zachary Mainen, Joseph J. Paton, Alfonso Renart
https://arxiv.org/abs/2604.23903 https://arxiv.org/pdf/2604.23903 https://arxiv.org/html/2604.23903
arXiv:2604.23903v1 Announce Type: new
Abstract: Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative neurocybernetic models: understandable dynamical models that capture the closed-loop coupling of brain, body and environment, treat the brain as a controller pursuing latent objectives, represent structured variation across scales, and scale to heterogeneous datasets. Such models shift the goal from predicting neural recordings in isolation to inferring the organizing principles that govern neural and behavioral dynamics. We outline a practical route toward this goal by combining nonlinear state-space models and meta-dynamical extensions with scalable inference, knowledge distillation, mixed open- and closed-loop training, and connectomics-informed architectures. By pooling complementary constraints from recordings, behavior, perturbations and anatomy, integrative neurocybernetic models can provide statistical amplification, few-shot generalization, and mechanistic insight into shared dynamical structure, individual variation, and the control objectives that govern behavior. This agenda offers a model-centric path from fragmented data to a mechanistic science of how brains produce behavior.
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New Marquette Law School national survey finds high approval of Iran cease-fire, low support for the war, and few who think U.S. goals have been achieved (Charles Franklin/Homepage)
https://law.marquette.edu/poll/2026/04/22/new-marquette-law-school-national-survey-finds-high-approval-of-iran-cease-fire-low-support-for-the-war-and-few-who-think-u-s-goals-have-been-achieved/
http://www.memeorandum.com/260422/p43#a260422p43
Finished reading "Seasons of Glass and Iron" by Amal El-Mohtar.
A short story collection — fairy tales, fantasy, and poems centering women's resilience and identity, gathered from years of El-Mohtar's commissioned work.
"John Hollowback and the Witch" is a delightful slow burn: a man guilty of wronging women, yet innocent in having no memory of it. "The Truth About Owls" handles displacement better than most novels.
4/5 ⭐⭐⭐⭐
No entiendo cual es el problema de la gente a la que no le gustó Mario Galaxy. Yo salí completamente satisfecho. Es una película muy entretenida para niños y adultos con un fan service brutal. No encuentro que esté tan lejos de la primera.
3½★ 👉🏻 https://boxd.it/etSPzn
🇺🇦 #NowPlaying on KEXP's #Expansions
missing project:
🎵 Poisson D’Avril (Da’ Future Given a Deep Soul mix)
#missingproject
https://music-from-memory.bandcamp.com/track/missing-project-poisson-davril-galaxy-dub
https://open.spotify.com/track/0GCzWPpqnXqQ2THTB1eEM0
Apparently today is #ShowYourStripes day.
If there are still people unaware that #ClimateChange is happening... maybe we can get them up to speed by sharing our stripes.
If some who are aware it's happening think it's already "too late"... maybe we can tell them that ac…
In other news, my first 15x11" (roughly DIN A3) print came out with only minor issues, none of them show stoppers and I know what needs to be done to improve. So this is just a test print and it's a bit hard to capture, but the overall presence & level of detail is so amazing at this size! Hard to go back to smaller sizes now :)
To get here, I've been doing countless tests of different recipes and hardware (e.g. I had to disassemble my UV light to create a more uniform/unfocused li…
Morgen soll Cem Özdemir in Stuttgart zum Ministerpräsidenten gewählt werden. Rückblende in einen Wahlkampf, der eigentlich unmöglich zu gewinnen war:
https://www.swr.de/swraktuell/baden-wuerttemberg/cem-oezdemir-gruene-wahlkamp…
LinkedIn badly needs to understand that (1) given that I'm British, the University of Glasgow is not my "school" and (2) the fact that a small handful of Glasgow Uni graduates now work at a potential job does not mean I can wander up to them in the pub we all go to and ask them to do me a solid. It's been 30 years since I graduated, and about 10,000 new folks get their sheepskin every year. This is not an exclusive club!
Meu palpite para este jogo do Brasil é uma goleada por pelo menos três gols de diferença. Aí vamos ficar iludidos de que o time é bom e que o hexa vem. Só que seleção com talentos individuais jogando contra time fraco consegue se destacar mesmo se ela estiver bagunçada. Mas depois, quando enfrentarmos alguma seleção minimamente boa, aí veremos que o time estš uma porcaria rs.
#copaDoMundoDaFifa2026