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Relief of EGFR/FOS-downregulated miR-103a by loganin alleviates NF-kappaB-triggered inflammation and gut barrier disruption in colitis
Yan Li, Teng Hui, Xinhui Zhang, Zihan Cao, Ping Wang, Shirong Chen, Ke Zhao, Yiran Liu, Yue Yuan, Dou Niu, Xiaobo Yu, Gan Wang, Changli Wang, Yan Lin, Fan Zhang, Hefang Wu, Guodong Feng, Yan Liu, Jiefang Kang, Yaping Yan, Hai Zhang, Xiaochang Xue, Xun Jiang

Relief of EGFR/FOS-downregulated miR-103a by loganin alleviates NF-kappaB-triggered inflammation and gut barrier disruption in colitis
Due to the ever-rising global incidence rate of inflammatory bowel disease (IBD) and the lack of effective clinical treatment drugs, elucidating the detailed pathogenesis, seeking novel targets, and developing promising drugs are the top priority for IBD treatment. Here, we demonstrate that the levels of microRNA (miR)-103a were significantly downregulated in the inflamed mucosa of ulcerative colitis (UC) patients, along with elevated inflammatory cytokines (IL-1beta/TNF-alpha) and reduced tigh…