Tootfinder

A coupled fluid-dynamics-heat transfer model for 3D simulations of the aqueous humor flow in the human eye
Thomas Saigre (IRMA), Christophe Prud'Homme (IRMA), Marcela Szopos (MAP5 - UMR 8145), Vincent Chabannes (IRMA)
https://arxiv.org/abs/2404.19353 https://arxiv.org/pdf/2404.19353
arXiv:2404.19353v1 Announce Type: new
Abstract: Understanding human eye behavior involves intricate interactions between physical phenomena such as heat transfer and fluid dynamics. Accurate computational models are vital for comprehending ocular diseases and therapeutic interventions.This work focuses on modeling and simulating aqueous humor flow in the anterior and posterior chambers of the eye, coupled with overall heat transfer.Aqueous humor dynamics regulates intraocular pressure, crucial for understanding conditions like glaucoma.Convective effects from temperature disparities also influence this flow.Extending prior research, this work develops a comprehensive three-dimensional computational model to simulate coupled fluid-dynamic-heat transfer model, thus contributing to the understanding of ocular physiology.

Local nature of 0.1 Hz oscillations in microcirculation is confirmed by imaging photoplethysmography
Irina A. Mizeva, Natalia P. Podolyan, Oleg V. Mamontov, Anastasiia V. Sakovskaia, Alexei A. Kamshilin
https://arxiv.org/abs/2405.18760

Local nature of 0.1 Hz oscillations in microcirculation is confirmed by imaging photoplethysmography
Low-frequency oscillations in the human circulatory system is important for basic physiology and practical applications in clinical medicine. Our objective was to study which mechanism (central or local) is responsible for changes in blood flow fluctuations at around 0.1 Hz. We used the method of imaging photoplethysmography synchronized with electrocardiography to measure blood-flow response to local forearm heating of 18 healthy male volunteers. The dynamics of peripheral perfusion was reveal…

Modeling principles for a physiology-based whole-body model of human metabolism
Laura Hjort Blicher, Peter Emil Carstensen, Jacob Bendsen, Henrik Linden, Bj{\o}rn Hald, Kim Kristensen, John Bagterp J{\o}rgensen
https://arxiv.org/abs/2404.14224

Modeling principles for a physiology-based whole-body model of human metabolism
Physiological whole-body models are valuable tools for the development of novel drugs where understanding the system aspects is important. This paper presents a generalized model that encapsulates the structure and flow of whole-body human physiology. The model contains vascular, interstitial, and cellular subcompartments for each organ. Scaling of volumes and blood flows is described to allow for investigation across populations or specific patient groups. The model equations and the correspon…

Space Physiology and Technology: Musculoskeletal Adaptations, Countermeasures, and the Opportunity for Wearable Robotics
Shamas Ul Ebad Khan, Rejin John Varghese, Panagiotis Kassanos, Dario Farina, Etienne Burdet
https://arxiv.org/abs/2404.03363

Space Physiology and Technology: Musculoskeletal Adaptations, Countermeasures, and the Opportunity for Wearable Robotics
Space poses significant challenges for human physiology, leading to physiological adaptations in response to an environment vastly different from Earth. While these adaptations can be beneficial, they may not fully counteract the adverse impact of space-related stressors. A comprehensive understanding of these physiological adaptations is needed to devise effective countermeasures to support human life in space. This review focuses on the impact of the environment in space on the musculoskeleta…

Space Physiology and Technology: Musculoskeletal Adaptations, Countermeasures, and the Opportunity for Wearable Robotics
Shamas Ul Ebad Khan, Rejin John Varghese, Panagiotis Kassanos, Dario Farina, Etienne Burdet
https://arxiv.org/abs/2404.03363

Space Physiology and Technology: Musculoskeletal Adaptations, Countermeasures, and the Opportunity for Wearable Robotics
Space poses significant challenges for human physiology, leading to physiological adaptations in response to an environment vastly different from Earth. While these adaptations can be beneficial, they may not fully counteract the adverse impact of space-related stressors. A comprehensive understanding of these physiological adaptations is needed to devise effective countermeasures to support human life in space. This review focuses on the impact of the environment in space on the musculoskeleta…

Modeling the distribution of insulin in pancreas
Changbing Hu, Junyuan Yang, James D. Johnson, Jiaxu Li
https://arxiv.org/abs/2406.00458 https://

Modeling the distribution of insulin in pancreas
Maintenance of adequate physical and functional pancreatic $β$-cell mass is critical for the prevention or delay of diabetes mellitus. It is well established that insulin potently activates mitogenic and anti-apoptotic signaling cascades in cultured $β$-cells. Loss of $β$-cell insulin receptors is sufficient to induce type 2 diabetes in mice. However, it remains unclear whether the {\em in vitro} effect in human islets and the {\em in vivo} effects in mice can be applied to human physiology.…