@der_raddler@dresden.network2026-07-21 19:30:44
From Facebook:
After a tough and emotional decision, Jana Kesenheimer (010), who had been leading the FLINTA field, has decided to drop out of the General Classification to join her partner, Christian Holweck (014), and ride for a Race Finish as a pair.
The pair had completed most of their TCR training together over the last year, and although Jana hadn’t initially considered riding as a pair, their unexpected proximity during the first days of the race proved difficult. The str…
@arXiv_physicsinsdet_bot@mastoxiv.page2026-08-21 08:05:53
Nanoscale silicon sensor - guided new insights into early metabolic response of Escherichia coli to ampicillin
Yingtao Yu, Victoria Nolan, Zheqiang Xu, Allison Jones, George Alhoush, Zhen Zhang, Sanna Koskiniemi
https://arxiv.org/abs/2608.20014 https://arxiv.org/pdf/2608.20014 https://arxiv.org/html/2608.20014
arXiv:2608.20014v1 Announce Type: new
Abstract: Antibiotic killing is often attributed to inhibition of specific cellular targets, yet metabolic processes can strongly influence drug efficacy. However, the relationship between metabolic responses and antibiotic lethality remains incompletely understood. Here, we employed silicon nanowire field-effect transistor (SiNWFET) sensors to monitor real-time metabolic responses of Escherichia coli to ampicillin (AMP). AMP treatment induced a biphasic extracellular pH signature, characterized by rapid acidification followed by alkalization. Metabolomic analyses revealed that the initial acidification resulted from organic acid secretion, whereas the subsequent alkalization was associated with altered amino acid metabolism and formate flux. Using metabolic and respiratory mutants, we found that these extracellular signatures reflected pathway-specific metabolic rewiring that predicted bacterial killing. AMP lethality strongly correlated with ATP dynamics and formate secretion: strains exhibiting larger AMP-induced ATP increases and greater formate secretion showed enhanced susceptibility. In contrast to literature, changes in NADH and NADPH levels did not support redox stress as the primary bacterial-killing mechanism. Together, our findings identify formate metabolism as a key pathway underlying the elevated ATP levels associated with AMP bactericidal activity. These results demonstrate that SiNWFET sensors provide a versatile label-free tool for probing antibiotic mechanisms, rapidly assessing bacterial susceptibility, and potentially guiding antimicrobial therapy development.
toXiv_bot_toot
@roelgrif@mstdn.social2026-08-06 15:22:00
@arXiv_physicsinsdet_bot@mastoxiv.page2026-08-21 08:05:53
Nanoscale silicon sensor - guided new insights into early metabolic response of Escherichia coli to ampicillin
Yingtao Yu, Victoria Nolan, Zheqiang Xu, Allison Jones, George Alhoush, Zhen Zhang, Sanna Koskiniemi
https://arxiv.org/abs/2608.20014
@roelgrif@mstdn.social2026-08-06 18:58:04
Ze werd verdacht van overmatig botox gebruik maar dat bleek Parkinson te zijn. De laatste jaren heb ik haar ook niet meer gevolgd.
https://www.trouw.nl/binnenland/jerney-kaagman-1947-2026-was-een-frontvrouw-voor-alle-muzikanten~b2917…
@cazfi@social.linux.pizza2026-07-11 18:08:10
2019 meidän Kami voitti Sastamalan Sanataiturin, alakoululaisten sarjan. Palkintorahoilla hän osti videokameran, jonka käyttö jäi silloin kuitenkin vähäiseksi.
Nyt hän oli kaivanut sen esiin kätköistään, laittanut taas toimintakuntoon ja intoilee sen käytöstä. Parampi myöhään kuin ei milloinkaan? Ja on sen laatu videokuvauksessa kuulemma parempi kuin hänen nykyisenkään kännykkänsä, kunhan jaksaa hioa asetukset kohdilleen.
@heiseonline@social.heise.de2026-07-26 16:20:03
Drei Raumfahrer von der ISS zurückgekehrt
Sie verbrachten acht Monate im Weltall. Nun sind zwei russische Kosmonauten und ein US-Astronaut wieder zurück auf der Erde.
https://www.heise.de/news/Drei-…
@Dragofix@mastodontti.fi2026-08-02 10:52:06
Brenetsin järvi on kuivunut lähes kokonaan Sveitsissä – ”Surettaa nähdä paikka tällaisena” #Sveitsi
@Techmeme@techhub.social2026-07-05 15:15:32
Chainalysis: addresses linked to Iran, Russia, North Korea, and other US-sanctioned entities received $100B in crypto last year, almost 8x the amount in 2024 (Patricia Kowsmann/Wall Street Journal)
https://www.wsj.com/world/cryptocurrency-sanctions-evasion-d02b…
@kexpmusicbot@mastodonapp.uk2026-07-17 02:04:14
🇺🇦 #NowPlaying on KEXP's #DriveTime
KAGAMI:
🎵 Perfect Wave
#KAGAMI
https://kagamimusic.bandcamp.com/track/perfect-wave
https://open.spotify.com/track/5TxcAlGoqL6064Sw9izIYA