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2024-03-12 08:55:34

This https://arxiv.org/abs/2303.11342 has been replaced.
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An agent-based modelling framework to study growth mechanisms in EGFR-L858R mutant alveolar type II cells
Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not always carcinogenic, and have recently been reported in histologically normal lung tissue from patients with and without lung cancer. To investigate the outcome of EGFR mutation in healthy lung stem cells, we grew murine alveolar type-II organoids monoclonally in a 3D Matrigel. Our experiments showed that the \textit{E…