Tootfinder

Right now, stood where I am on the worn stone steps looking down into the darkness of the crypt
at St. Mary, Lastingham in Yorkshire,
you could say that this is the loneliest place on earth
-- Andy Marshall
https://www.digest.andymarshall.co/andy-ma…

Andy Marshall's Genius Loci Digest: 28 Nov 2025
When I walk back up into the nave, the visitor is there at the top of the steps, sat in a chair - as if he knew of the tenderness that was taking place beneath and was unable to enter in upon it.

Modeling the joint effects of genetic drift, mutation, and selection on loci that contribute to disease risk suggests that variation at many such loci is shaped more by their pleiotropic effects on non-disease traits than by their contribution to disease risk
https://doi.org/10.1093/genetics/iyaf22…

Breathless, I make it to the sweet spot and turn to face the monument.
Before I can fix the camera to the tripod, the scene before me stops me completely.
I’ve reached the monument not only at the edge of sunrise, but on the brink of the metaphysical
- as if I am the final piece in a vast jigsaw;
I, myself, a conduit that draws together time, space, history, light, and landscape.
In their coalescing, for the briefest of moments, I glimpse the sacred
and ga…

Andy Marshall's Genius Loci Digest: 7 Nov 2025
The standing stone before me has occupied this spot for around 4,500 years.

Cuckoo eggs match the eggs of their adoptive hosts thanks to (mostly) loci inherited from their mothers, who put them there — impressive multifaceted genomic study #science