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Interaction Dynamics of Borrelia Surface Proteins with Fibronectin
Kavindi Madduma Hewage, Carlos Munoz, Mehmet Ozdogan, Catherine A. Brissette, Nuri Oncel
https://arxiv.org/abs/2510.11931

Interaction Dynamics of Borrelia Surface Proteins with Fibronectin
Lyme disease, caused by the bacterium Borrelia burgdorferi, is a significant public health concern in North America, with approximately 500,000 cases reported annually in the United States. The dissemination of B. burgdorferi from the initial tick bite site to various tissues is facilitated by surface adhesins that bind to extracellular matrix (ECM) proteins such as fibronectin (Fn). This study investigates the binding dynamics of B. burgdorferi surface proteins RevA, BBK32, BmpA, OspA, and Osp…