Tootfinder

TopoSPAM: Topology grounded Simulation Platform for morphogenesis and biological Active Matter
Abhinav Singh (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, Center for Systems Biology Dresden, Dresden, Germany, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA), Abhijeet Krishna (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, Center for Systems Biology Dresden, Dresden, Germany), Aboutaleb …

TopoSPAM: Topology grounded Simulation Platform for morphogenesis and biological Active Matter
We present a topology grounded, multiscale simulation platform for morphogenesis and biological active matter. Morphogenesis and biological active matter represent keystone problems in biology with additional, far-reaching implications across the biomedical sciences. Addressing these problems will require flexible, cross-scale models of tissue shape, development, and dysfunction that can be tuned to understand, model, and predict relevant individual cases. Current approaches to simulating anato…

Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity
Gengqiang Xie, Chaity Modak, Olalekan H Usman, Raphael WF Tan, Nicole Coca, Gabriela De Jesus, Yue Julia Wang, D. Thirumalai, Xin Li, Jerome Irianto
https://arxiv.org/abs/2509.25680

Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity
Rotational migration is one specific form of collective cell migration when epithelial cells are confined in a spherical geometry, such as in the epithelial acini. This tissue-level rotation motion is crucial for the morphogenesis of multiple epithelial systems. Here, we introduce a new primary human model for the study of rotational migration, pancreatic ductal organoids. Live imaging revealed the persistent rotation of the organoids over time. By tracking the nuclei, the three- dimensional tr…

Competing forces of polarization and confinement generate cellular chirality in a minimal model
Egun Im, Ghina Badih, Laetitia Kurzawa, Andreas Buttensch\"on, Calina Copos
https://arxiv.org/abs/2510.11642

Competing forces of polarization and confinement generate cellular chirality in a minimal model
Left-right axis specification is a vital part of embryonic development that establishes the left and the right sides of an embryo. Asymmetric organ morphogenesis follows asymmetric signaling cascades, which in turn follow asymmetric events on the cellular scale. In a recent study, Badih et al.\ reported cell-scale movement asymmetries in spontaneously rotating pairs of endothelial cells confined to a circular fibronectin-coated island. Importantly, the authors demonstrate that cytoskeletal cont…