Tootfinder

Robust multicellular programs dissect the complex tumor microenvironment and track disease progression in colorectal adenocarcinomas
Loan Vulliard, Teresa Glauner, Sven Truxa, Miray Cetin, Yu-Le Wu, Ronald Simon, Laura Behm, Jovan Tanevski, Julio Saez-Rodriguez, Guido Sauter, Felix J. Hartmann
https://arxiv.org/abs/2510.05083

Robust multicellular programs dissect the complex tumor microenvironment and track disease progression in colorectal adenocarcinomas
Colorectal cancer (CRC) is highly heterogeneous, with five-year survival rates dropping from $\sim$90% in localized disease to $\sim$15% with distant metastases. Disease progression is shaped not only by tumor-intrinsic alterations but also by the reorganization of the tumor microenvironment (TME). Metabolic, compositional, and spatial changes contribute to this progression, but considered individually they lack context and often fail as therapeutic targets. Understanding their coordination cou…

🎲 Randomness reveals hidden order in the plant world
#plants

Randomness reveals hidden order in the plant world
In the intricate architecture of plant tissues, beauty often emerges from chaos, according to new research from Cornell researchers. Findings from a recent study show how randomness and growth together create the striking cellular patterns that shape plant organs—and perhaps all multicellular life.

Mapping gene expression dynamics to developmental phenotypes with information entropy analysis
Ben Ansbacher, Malachy Guzman, Jordi Garcia-Ojalvo, Arjendu K Pattanayak
https://arxiv.org/abs/2510.04101 …

Mapping gene expression dynamics to developmental phenotypes with information entropy analysis
The development of multicellular organisms entails a deep connection between time-dependent biochemical processes taking place at the subcellular level, and the resulting macroscopic phenotypes that arise in populations of up to trillions of cells. A statistical mechanics of developmental processes would help to understand how microscopic genotypes map onto macroscopic phenotypes, a general goal across biology. Here we follow this approach, hypothesizing that development should be understood as…

Controlled protein synthesis and spatial organisation in microfluidic environments
Aukse Gaizauskaite, Emma E. Crean, Imre Banlaki, Jan L. Kalkowski, Henrike Niederholtmeyer
https://arxiv.org/abs/2509.22285

Controlled protein synthesis and spatial organisation in microfluidic environments
Performing cell-free expression (CFE) in tailored microfluidic environments is a powerful tool to investigate the organisation of biosystems from molecular to multicellular scales. While cell-free transcription-translation systems simplify and open up cellular biochemistry for manipulation, microfluidics enables miniaturisation and precise control over geometries and reaction conditions. In this review, we highlight the benefits of combining microfluidics with CFE reactions for the study and en…

Harmonic fields and the mechanical response of a cellular monolayer to ablation
Oliver E. Jensen, Christopher K. Revell
https://arxiv.org/abs/2510.05193 https://

Harmonic fields and the mechanical response of a cellular monolayer to ablation
Multicellular tissues, such as the epithelium coating a developing embryo, often combine complex tissue shapes with heterogeneity in the spatial arrangement of individual cells. Discrete approximations, such as the cell vertex model, can accommodate these geometric features, but techniques for analysis of such models are underdeveloped. Here, we express differential operators defined on a network representing a monolayer of confluent cells in the framework of discrete exterior calculus, conside…

Crosslisted article(s) found for q-bio.TO. https://arxiv.org/list/q-bio.TO/new
[1/1]:
- Robust multicellular programs dissect the complex tumor microenvironment and track disease progre...
Vulliard, Glauner, Truxa, Cetin, Wu, Simon, Behm, Tanevski, Saez-Rodriguez, Sauter, Hartmann
…