Tootfinder

Prediction and control of geometry-induced nematic order in growing multicellular systems
Lukas Hupe, Jonas Isensee, Ramin Golestanian, Philip Bittihn
https://arxiv.org/abs/2506.10867

Prediction and control of geometry-induced nematic order in growing multicellular systems
In densely-packed two-dimensional systems of growing cells, such as rod-shaped bacteria, a number of experimental and numerical studies report distinct patterns of nematic orientational order in the presence of confinement. So far, these effects have been explained using variations of growing active nematic continuum theories, which incorporate feedback between growth-induced active stresses, the resulting material flow and nematic orientation, and were adapted to the specific geometry under in…

Weekend #Plankton #Factoid 🦠🦐
I've always been impressed by this video from New Scientist about #copepods, the planet's most abundant multicellular organism, with interviews from several UK uni…

Chemotaxis-Driven Instabilities Govern Size, Shape and Migration Efficiency of Multicellular Clusters
Monika Sanoria, Gema Malet-Engra, Giorgio Scita, Nir Gov, Ajay Gopinathan
https://arxiv.org/abs/2506.00310

Chemotaxis-Driven Instabilities Govern Size, Shape and Migration Efficiency of Multicellular Clusters
The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dynamics and instabilities, but their physical origin, functional benefits, and role in overall chemotactic migration remain unclear. Here, we combine computational modeling and experimental observations of malignant lymphocyte cluster migration in vitro to understand how these dyn…

Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions
Maria Yampolskaya, Laertis Ikonomou, Pankaj Mehta
https://arxiv.org/abs/2506.04219

Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions
Multicellular organisms develop a wide variety of highly-specialized cell types. The consistency and robustness of developmental cell fate trajectories suggests that complex gene regulatory networks effectively act as low-dimensional cell fate landscapes. A complementary set of works draws on the theory of dynamical systems to argue that cell fate transitions can be categorized into universal decision-making classes. However, the theory connecting geometric landscapes and decision-making classe…

This https://arxiv.org/abs/2503.05053 has been replaced.
initial toot: https://mastoxiv.page/@arXi…

Multi-phase-field Models of Biological Tissues
The development of complex multicellular organisms from a single parent cell is a highly orchestrated process that cells conduct collectively without central guidance, creating intricate dynamic patterns essential for development and regeneration. Despite significant advances in imaging spatiotemporal dynamics of cell collectives and mechanical characterization techniques, the role of physical forces in biological functions remains poorly understood. Physics-based models are crucial in compleme…

Rosette formations as symmetry-breaking events: theory and experiment
Mattia Miotto, Giorgio Gosti, Maria Rosito, Michela Dell'Omo, Viola Folli, Valeria de Turris, Giancarlo Ruocco, Alessandro Rosa, Matteo Paoluzzi
https://arxiv.org/abs/2505.20543

Rosette formations as symmetry-breaking events: theory and experiment
Multicellular rosettes are observed in different situations such as morphogenesis, wound healing, and cancer progression. While some molecular insights have been gained to explain the presence of these assemblies of five or more cells around a common center, what are the tunable, global features that favors/hinders their formation is still largely unknown. Here, we made use of a Voronoi dynamical model to investigate the ingredients driving the emergence of rosettes characterized by different d…