Tootfinder

Ein Team am Helmholtz-Zentrum für Infektionsforschung entwickelt mit Unterstützung des Deutschen Zentrums für Infektionsforschung ein lebendes #Biotherapeutikum auf Basis von Klebsiella oxytoca, das krankmachende Bakterien wie K. pneumoniae aus dem Darm verdrängen soll.
Ziel ist eine Kapsel mit gefriergetrockneten

Mit der Kraft des Mikrobioms gegen Infektionen
DZIF fördert HZI-Projekt zur Entwicklung eines lebenden Biotherapeutikums. Klebsiella oxytoca verdrängt dabei andere pathogene Bakterien im Darm.

Predicting Microbial Ontology and Pathogen Risk from Environmental Metadata with Large Language Models
Hyunwoo Yoo, Gail L. Rosen
https://arxiv.org/abs/2507.21980 https://

Predicting Microbial Ontology and Pathogen Risk from Environmental Metadata with Large Language Models
Traditional machine learning models struggle to generalize in microbiome studies where only metadata is available, especially in small-sample settings or across studies with heterogeneous label formats. In this work, we explore the use of large language models (LLMs) to classify microbial samples into ontology categories such as EMPO 3 and related biological labels, as well as to predict pathogen contamination risk, specifically the presence of E. Coli, using environmental metadata alone. We ev…

Integrating Endothelial-Derived Hyperpolarizing Signaling into a Multitarget Therapeutic Strategy for Microvascular Disease
Paolo Madeddu, Styliani Goulopoulou, David Wambeke
https://arxiv.org/abs/2508.01618

Integrating Endothelial-Derived Hyperpolarizing Signaling into a Multitarget Therapeutic Strategy for Microvascular Disease
Endothelial cells release various vasorelaxing molecules, such as nitric oxide and prostacyclin, along with defined factors that induce hyperpolarization of vascular smooth muscle cells through the opening of calcium-sensitive potassium channels. Potassium channel-dependent vasorelaxation is prevalent in microvessels and can partially compensate for deficiencies in other vasodilatory mechanisms. Enhancing this backup vasorelaxant mechanism may aid the treatment of microvascular disorders, such …

Predicting Antimicrobial Resistance (AMR) in Campylobacter, a Foodborne Pathogen, and Cost Burden Analysis Using Machine Learning
Shubham Mishra, The Anh Han, Bruno Silvester Lopes, Shatha Ghareeb, Zia Ush Shamszaman
https://arxiv.org/abs/2509.03551

Predicting Antimicrobial Resistance (AMR) in Campylobacter, a Foodborne Pathogen, and Cost Burden Analysis Using Machine Learning
Antimicrobial resistance (AMR) poses a significant public health and economic challenge, increasing treatment costs and reducing antibiotic effectiveness. This study employs machine learning to analyze genomic and epidemiological data from the public databases for molecular typing and microbial genome diversity (PubMLST), incorporating data from UK government-supported AMR surveillance by the Food Standards Agency and Food Standards Scotland. We identify AMR patterns in Campylobacter jejuni and…

MicroTrace: A Lightweight R Tool for SNP-Based Pathogen Clustering in Outbreak Detection
Kaitao Lai
https://arxiv.org/abs/2507.08060 https://

MicroTrace: A Lightweight R Tool for SNP-Based Pathogen Clustering in Outbreak Detection
MicroTrace is an open-source R tool that performs SNP-based hierarchical clustering to detect potential transmission clusters from pathogen whole-genome sequencing (WGS) data. Designed for epidemiologists, microbiologists, and genomic surveillance teams, it processes SNP distance matrices and outputs dendrograms and cluster tables with optional metadata integration. MicroTrace enables reproducible outbreak detection workflows with minimal setup.

Exploring Causal Mediation Analysis in Bacterial Vaginosis Challenges
Debarghya Nandi, Soumya Sahu, Supriya Mehta, Dulal K. Bhaumik
https://arxiv.org/abs/2507.20547 https://

Exploring Causal Mediation Analysis in Bacterial Vaginosis Challenges
Bacterial Vaginosis (BV) affects nearly 23-29% of women worldwide and increases risk of miscarriage, preterm birth, and sexually transmitted infections. It involves a shift in the vaginal microbiome from Lactobacillus dominance to a diverse bacterial composition. Understanding causal pathways linking behavioral factors to BV risk is essential for effective intervention. Observational studies have identified pathogenic bacteria associated with BV, and causal mediation analysis can clarify how be…