Tootfinder

TopROI: A topology-informed network approach for tissue partitioning
Sergio Serrano de Haro Iv\'a\~nez, Joshua W. Moore, Lucile Grzesiak, Eoghan J. Mullholand, Heather Harrington, Simon J. Leedham, Helen M. Byrne
https://arxiv.org/abs/2510.12772

TopROI: A topology-informed network approach for tissue partitioning
Mammalian tissue architecture is central to biological function, and its disruption is a hallmark of disease. Medical imaging techniques can generate large point cloud datasets that capture changes in the cellular composition of such tissues with disease progression. However, regions of interest (ROIs) are usually defined by quadrat-based methods that ignore intrinsic structure and risk fragmenting meaningful features. Here, we introduce TopROI, a topology-informed, network-based method for par…