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Optimal monophasic, asymmetric electric field pulses for selective transcranial magnetic stimulation (TMS) with minimised power and coil heating
Ke Ma, Andrey Vlasov, Zeynep B. Simsek, Jinshui Zhang, Yiru Li, Boshuo Wang, David L. K. Murphy, Jessica Y. Choi, Maya E. Clinton, Noreen Bukhari-Parlakturk, Angel V. Peterchev, Stephan M. Goetz
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Optimal monophasic, asymmetric electric field pulses for selective transcranial magnetic stimulation (TMS) with minimised power and coil heating
Transcranial magnetic stimulation (TMS) with asymmetric electric field pulses, such as monophasic, offers directional selectivity for neural activation but requires excessive energy. Previous pulse shape optimisation has been limited to symmetric pulses or heavily constrained variations of conventional waveforms without achieving general optimality in energy efficiency or neural selectivity. We implemented an optimisation framework that incorporates neuron model activation constraints and flexi…