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Advanced Characterization Methods for Crystals of an Extraordinary Material
Vivekananda Bal, Jackie M. Wolfrum, Paul W. Barone, Stacy L. Springs, Anthony J. Sinskey, Robert M. Kotin, Richard D. Braatz
https://arxiv.org/abs/2510.05867

Advanced Characterization Methods for Crystals of an Extraordinary Material
Physicochemical characterization of materials is central to the field of science and engineering and is essential to design new/engineered materials with specific properties. Assays available for small-molecules, e.g., XRD, NMR, LC-MS, can't be applied to macromolecules easily. Thus, it is extremely challenging to characterize complex materials such as adeno-associated virus capsids (MW 5.8MDa). Capsid crystals produced in hanging-drop are characterized in-situ using cross-polarized light and e…