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Competing forces of polarization and confinement generate cellular chirality in a minimal model
Egun Im, Ghina Badih, Laetitia Kurzawa, Andreas Buttensch\"on, Calina Copos
https://arxiv.org/abs/2510.11642

Competing forces of polarization and confinement generate cellular chirality in a minimal model
Left-right axis specification is a vital part of embryonic development that establishes the left and the right sides of an embryo. Asymmetric organ morphogenesis follows asymmetric signaling cascades, which in turn follow asymmetric events on the cellular scale. In a recent study, Badih et al.\ reported cell-scale movement asymmetries in spontaneously rotating pairs of endothelial cells confined to a circular fibronectin-coated island. Importantly, the authors demonstrate that cytoskeletal cont…