Multisensory learning recruits visual neurons into an olfactory memory engram
Zeynep Okray, Nils Otto, Anna A. Cook, Clifford Talbot, Ashwin Miriyala, Mart\'in Klappenbach, Ciara Stern, Kieran Desmond, Paola Vargas-Gutierrez, Scott Waddell
https://arxiv.org/abs/2604.28007 https://arxiv.org/pdf/2604.28007 https://arxiv.org/html/2604.28007
arXiv:2604.28007v1 Announce Type: new
Abstract: Associating multiple sensory cues with a single experience or object is a fundamental process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory expression are unknown. Here we demonstrate multisensory appetitive and aversive memory in Drosophila. Combining colours and odours improved memory performance, even when each sensory modality was tested alone. Temporal control of neuronal function revealed visually-selective mushroom body Kenyon Cells (KCs) to be required for enhancement of visual and olfactory memory recall after multisensory training. Synapse-level connectomics suggests that valence-relevant dopaminergic reinforcement could permit the KC-spanning serotonergic DPM neurons to bridge between previously modality-selective KC streams. Consistent with this model, DPM transmission is uniquely required during multisensory memory formation and for enhanced expression of olfactory memory afterwards. In addition, signalling via the DopR1 dopamine receptor is required in APL neurons, suggesting that reinforcing dopamine could locally release GABA-ergic inhibition to permit bridging microcircuits to function. Cross-modal binding thereby expands the KCs representing the olfactory memory engram into those representing the colour. We propose that broadening of the engram improves memory performance after multisensory learning and permits a single sensory feature to retrieve the memory of the multimodal experience.
toXiv_bot_toot
Inside linebacker Segun Olubi’s winding, resilient road to Raiders https://www.reviewjournal.com/sports/raiders/inside-linebacker-segun-olubis-winding-resilient-road-to-raiders-3843888/
The crawlers of Facebook and GPTbot are fighting who gets the most garbage from my Discworld LLM poisoner this week, but getting almost 8 GiB
#iocaine
https://olyfjan.blomi.is
sometimes i wish my salad cravings would kick in at a lower temperature
made a punchy greek-ish salad with feta olives cucumber tomato pepper radish onion herbs balsamic evoo and a bit of toast to soak up the juices
🇺🇦 #NowPlaying on BBCRadio3's #ThroughTheNight
Lars‐Erik Larsson, Peter Olofsson, Patrik Swedrup, Åsa Karlsson, Lars Frykholm & Uppsala Kammarsolister:
🎵 String Quartet No 3
#LarsErikLarsson #PeterOlofsson
https://open.spotify.com/track/66IhdjAa4bWFnRh1Edo0HN
Net begonnen de dienst bij de De Kapel in Hilversum
Viering met Erik Jan Tillema - YouTube
https://www.youtube.com/watch?v=O4LeyWpCdWg
Viering met Erik Jan Tillema - De Kapel
https://www.dekapel.nu/viering-met-erik-jan-tillema/
Edit: bijzondere dienst die naar aanleiding van de actualiteit ('Vinkeveen') een nieuwe lading kreeg.
Sonnet 107 - CVII
Not mine own fears, nor the prophetic soul
Of the wide world dreaming on things to come,
Can yet the lease of my true love control,
Supposed as forfeit to a confined doom.
The mortal moon hath her eclipse endured,
And the sad augurs mock their own presage;
Incertainties now crown themselves assured,
And peace proclaims olives of endless age.
Now with the drops of this most balmy time,
My love looks fresh, and Death…
You can now donate to Olivia Chow campaign for mayor.
If you have the spare cash flow, the refund from the city after the election is actually quite generous. $100 donation = $75 refund later
https://www.oliviachow.ca/donate