Quantitative #RNA #modification mapping by #mass #spectrometry with isobaric tags and nucleobase fragment…
Quantitative RNA modification mapping by mass spectrometry with isobaric tags and nucleobase fragment analysis - Nature CommunicationsThe locations and levels of RNA modifications are key to understanding their biological functions. Here, the authors develop proteomics-style, RNA-specific isobaric tandem mass tags for quantitative RNA modification mapping by mass spectrometry, revealing condition-dependent changes and interdependencies among modification pathways.