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@arXiv_qbioNC_bot@mastoxiv.page
2026-07-21 08:08:14

Emergent topological structure in spontaneous brain-organoid activity
Eve Bodnia, Margaux Basart, Sofie Hai, Lenzie Ford, Nina Miolane, Kenneth S. Kosik, Dirk Bouwmeester, Lincoln D. Carr
arxiv.org/abs/2607.16517 arxiv.org/pdf/2607.16517 arxiv.org/html/2607.16517
arXiv:2607.16517v1 Announce Type: new
Abstract: Neural activity is widely held to organize on low-dimensional structure embedded in a high-dimensional state space. Persistent homology reads such structure directly from the pattern of pairwise correlations, without assuming in advance which variables are relevant. We apply persistent homology to microelectrode-array (MEA) recordings of spontaneous activity from human (Lancaster) and mouse (Pa\c{s}ca) cortical organoids, spanning $26$--$234$ simultaneously sorted units, and ask whether topological data analysis resolves structure at the node counts that neural recordings actually deliver. Building weighted networks in correlation space and characterizing them by Vietoris--Rips filtration, we find that the first homology ($H_1$, loops) rises significantly above a rate- and population-preserving null in $14$ of $18$ datasets. This loop structure occupies a non-redundant core: it is robust to random removal of units yet disrupted by targeted removal of the units that carry it. Topological richness grows with network size, and second homology ($H_2$) emerges significantly above the null only in the larger networks. These results show that persistent homology resolves structured topology in neural recordings at the scale experiments actually deliver.
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@arXiv_csHC_bot@mastoxiv.page
2026-08-12 08:20:59

ResonaVis: Visualizing Interactive Music Data to Support Reflective Music Composition for Therapeutic Contexts
Abhishek Karwankar, Elise Ruggiero, Daniel Stevens, Matthew Louis Mauriello
arxiv.org/abs/2608.10338 arxiv.org/pdf/2608.10338 arxiv.org/html/2608.10338
arXiv:2608.10338v1 Announce Type: new
Abstract: Designing music for therapeutic contexts requires navigating complex relationships between musical structure and listeners' sensory responses, yet composers often lack structured representations of these interactions, relying instead on intuition. We present ResonaVis, an interactive visualization system that helps composers analyze interaction and audio data from prior sessions with children with Autism Spectrum Disorder (ASD), informing future compositions. ResonaVis integrates audio features and interaction logs to capture how children engage with layered musical compositions, representing this engagement through coordinated visualizations of temporal transitions, layer co-occurrence, rhythmic activity, and spectral characteristics. Rather than prescribing strategies or supporting therapy sessions directly, the system surfaces patterns in past session data to support data-informed reflection during composition. We evaluated ResonaVis through a mixed-methods study with eight music students and a follow-up case study with two experienced composers. Results demonstrate good usability (SUS = 72.23), exceeding benchmarks for early prototypes, and show that participants could identify interaction patterns, reason about layer relationships, and make informed compositional decisions with high perceived performance and low frustration. Confidence in interpreting interaction and acoustic data for ASD-focused composition increased significantly across multiple dimensions (p < 0.05), with qualitative findings suggesting a shift toward more adaptive, data-informed composition. This work contributes a visualization design space for therapeutic music interaction data, an integrated system for compositional reflection, and empirical evidence that visualization tools support analytical reasoning and confidence in data-informed creative practice. (Abstract shortened for arXiv.)
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@arXiv_astrophGA_bot@mastoxiv.page
2026-09-09 09:33:18

Closed-Form of the Local Galactic Potential and Stellar Distribution Function from Gaia DR3
Indranil Das, Adam Kamoski, Dora Demiri, Brianna Isola, Hanieh Karimi, Dmitrii S. Zagorulia
arxiv.org/abs/2609.09011 arxiv.org/pdf/2609.09011 arxiv.org/html/2609.09011
arXiv:2609.09011v1 Announce Type: new
Abstract: The local dark matter density determines the strength of the signal expected in direct-detection experiments, yet published estimates from stellar motions disagree by more than their errors, and the most recent machine-learning analysis of Gaia data finds a local density consistent with zero. According to Jeans' theorem, a distribution function built from integrals of motion satisfies the collisionless Boltzmann equation (CBE) trivially for any choice of potential, so a search that simultaneously fits the distribution function and the potential to the CBE identifies neither. Our pipeline instead estimates the distribution function in isolation, linearizing the equation in terms of accelerations and allowing for direct measurement of the local force field, and then fits closed forms to that field via symbolic regression. Throughout, we find that the usable information lies not in the CBE residual but in the stellar number counts, the observable most distorted by survey selection. Along the vertical profile, our recovered potential agrees with the classical self-gravitating isothermal disc.
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