2025-12-29 02:24:01
🦥 Long-term calorie restriction may slow normal brain aging
#diet …
🦥 Long-term calorie restriction may slow normal brain aging
#diet …
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
#Biodrones: Russian company successfully tests remote-controlled pigeons with brain implants https://www.notebookcheck.net/Company-succes…
Ĉu pensado dependas de lingvo? Aperas pli da atestaĵo ke la respondo estas ne.
(angle):
https://www.quantamagazine.org/the-polyglot-neuroscientist-resolving-how-the-brain-parses-language-20251205/
Renewed work toward a visual prosthesis (brain implant) in the #LGN instead of visual cortex https://nin.nl/news/first-ever-recording-of-a-crucial-visual-structure-in-the…
The brain isn’t a computer. ¯\_(ツ)_/¯
A new study suggests that #dementia may be driven in part by faulty blood flow in the brain.
Researchers found that losing a key lipid causes blood vessels to become overactive,
disrupting circulation and starving brain tissue.
When the missing molecule was restored, normal blood flow returned.
This discovery opens the door to new treatments aimed at fixing vascular problems in …
How diamonds are being converted to quantum sensors by inserting tiny imperfections, opening up potential uses in medicine, brain-computer interfaces, and more (Financial Times)
https://www.ft.com/content/0b309cd2-aa74-428e-b37b-067665ef17ea
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 80270 edges.
Tags: Biolo…
Nasal spray as noninvasive brain tumor treatment developed by researchers
https://thehill.com/policy/healthcare/5663293-nasal-drops-fight-deadly-brain-cancer-research/
Editorial: The explosive growth of brain-computer interface technology in clinical trials in China: technological leap forward? https://journals.lww.com/jagr/fulltext/2025/12000/the_explosive_growth_of_brain_computer_interface.1.aspx…
Series C, Episode 10 - Ultraworld
ORAC: I don't know. What is the best cure for water on the brain?
VILA: A tap on the head.
https://blake.torpidity.net/m/310/240 B7B2
I made the familiar point yesterday during a panel discussion that even if AI were approaching human intelligence, we're nowhere near human power efficiency (in "intelligence per watt")
But is that actually true anymore? We need huge power to train models, but once we have them trained, distilled and quantized, what do we have?
The human brain draws abt 20 Watts. An M4 doing local inference on a heavily quantized LLM won't draw more than 40 Watts.
Measuring the consequences of plastic contamination #environment
Brains aren’t computers.
It’s self-evident:
🤖 Computers (even primitive ones) can do a lot of stuff that no brain can.
🧠 Brains (even primitive ones) can do a lot of stuff no computer can.
You know what’s really interesting?
That brains never evolved to be really fast and precise calculating things—which is exactly the raison d’être for computers.
(It’s either not necessary for consciousness or maybe actively detrimental to it?)
The more I use FreeCAD, the more I understand the nature of the specific and profound brain damage required to use it effectively, but I'm still getting lost. Stuff I would have had done in 20 minutes in Inventor has taken me all evening!
😵💫 Targeted ultrasound can shape the brain's reward-seeking mechanisms
#ultrasound
An obsequious “always yes” machine…well, your head might say it’s far-fetched, but the instinct for psychological self-defense won’t let your brain let go of it.
You might say “Don’t they understand [fact about LLMs]???” but often the appeal isn’t factual; it’s emotional.
Ignore that at your peril.
8/
Prototype device restores lost smell by teaching the brain to feel odors https://medicalxpress.com/news/2025-11-prototype-device-lost-brain-odors.html
Substitution of human olfaction by the trigeminal system
Study Finds 40% of fMRI Brain Scans Misread Neural Activity
https://ground.news/article/study-finds-40-of-fmri-brain-scans-misread-neural-activity_7aa5a7
cintestinalis: Tadpole larva brain (C. intestinalis)
Entire connectivity matrix for the complete brain of a larva of Ciona intestinalis. Each directed edge represents a synaptic connection from pre-synaptic cell i to post-synaptic cell j (may not be a neuron). Edge weights represent the cumulative depth of presynaptic contacts in µm.
This network has 205 nodes and 2903 edges.
Tags: Biological, Connectome, Weighted
Flexion, which is building a full autonomy stack for humanoid robots, raised a $50M Series A from DST Global Partners, NVentures, and others, after a $7M seed (Mary Ann Azevedo/Crunchbase News)
https://news.crunchbase.com/venture/robotic-brain-building-star…
OMG, my gaming computer is rotting my brain. I’m dumping it next week. 🤦
Lastly, whenever I do work with people through a specific case of them having felt like they needed to rely on an LLM, it often goes like this.
They feel guilty and ashamed.
They explain how impossible getting that task done felt with their time and energy constraints.
Yet when I talk them through other ways of solving the same problem, often we end up completing the work much quicker than it even took them to prompt the damn LLM to begin with.
And at the end, I have often seen relief - as if the person has forgotten that there are ways to work quickly while trusting their own brain, getting help in collaboration with another person rather than from a machine.
I do kind of love seeing someone realize that the AI they thought was saving them time actually caused more hassle and stress than it was worth. And that there’s a better way.
Series B, Episode 12 - The Keeper
CALLY: Or he said it was Lurgen's brain that was on a thong. That might not be the same thing.
AVON: If you find the brain print, and consequently the location of Star One, what then?
BLAKE: Finish what we started.
https://blake.torpidity.net/m/212/7
I was just thinking about how the fact that #Musk named his AI "Grok" is evidence that he "reads sci-fi" in the same way he "plays video games." Like, he claims to do it but when it comes time to show the evidence it's clear he does not actually "grok" it.
Like... To grok something is to have a layer deeper than simply knowledge, but mathematically encoding statistical relationships between words is pretty obviously not even understanding much less qualifying as "groking" it. In the book, the ability to grok something is also the ability to annihilate that thing with a thought. Just pretending that an LLM actually *was* something that could become AGI (which it's not), this name would imply the AI would have the power to annihilate reality. That's bad. That's a bad name for an AI.
And why would a greedy fascist name something of his after something an anarchist communist space Jesus taught to the hippie cult he started? There are so many layers of facepalm to this. It's some kind of php-esque fractal of incompetence.
Like, there's no reason to talk about this but my brain does this to me sometimes and now it's your problem.
😵 Diesel exhaust particles disrupt the function of brain's immune cells, study shows
https://medicalxpress.com/news/2025-11-diesel-exhaust-particles-disrupt-function.html
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
An #earworm popping up in my brain lately. A poem I was made to memorize when I was 14. It re-emerges every couple years, for no reason I can figure. tbh, I usually only remember verbatim the first few lines or so, and have to look it up again. It’s one of those things, like advertising jingles from many years ago, that have lodged in my memory. 🎶You’ll wonder where the yellow went when you brush y…
An electrode-based #Neuralink #Blindsight brain implant in visual cortex will not scale to large numbers of blind patients nor to normal-like vision beyond showing a few rough edges
New post: Neovim as a Java Ide with Lombok support
#blog
I'm listening to the most recent episode of #YouAreNotSoSmart, David McRaney's podcast @…. It's about the Trolley problem and morality.
They keep talking about a variation of the trolley problem where, instead of pulling the lever t…
As a graduate student at MIT, Steve Ramirez successfully created false memories in the lab.
Now, as a neuroscientist working at the frontiers of brain science, he foresees a future where
we can replace our negative memories with positive ones.
In "How to Change a Memory", Ramirez draws on his own memories
—of friendship, family, loss, and recovery
—to reveal how memory can be turned on and off like a switch,
edited, and even
constructed fro…
Source: Sam Altman's Merge Labs, which seeks to read brain activity using ultrasound, is being spun out of LA-based nonprofit Forest Neurotech (Emily Mullin/Wired)
https://www.wired.com/story/sam-altman-brain-computer-interf…
My brain on philosophy.
#ProjektMaster
I like where this is going.
I think #ai has analyzed my brain 🧠
🧐🤣
fly_hemibrain: Fly hemibrain (2020)
A synaptic map of the hemibrain connectome of fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using EM reconstruction techniques. Neurons are labeled by their type. Edges are annotated by the connection strength between the neurons.
This network has 21739 nodes and 4259624 edges.
Tags: Biological, Connectome, Weighted, Metadata
Four fast, weird songs on this EP from 2025 via Buffalo's synth punk freaks HAVANA SYNDROME. Love the guy's voice, he sounds totally unhinged. I love singers that sound unhinged. 😂
https://swimmingfaithrecords.bandcamp.com/album/kill-your-brain
@… Thank you for interesting post! While I struggle with different issues, I can very much relate to the trilingual challenges…
Every time I see a study about the supposed benefits of multilingualism for your brain I think, hopefully I eventually get to reap these benefits, because for now, I’m just struggling to express myself in three languages, a…
@… Thank you for interesting post! While I struggle with different issues, I can very much relate to the trilingual challenges…
Every time I see a study about the supposed benefits of multilingualism for your brain I think, hopefully I eventually get to reap these benefits, because for now, I’m just struggling to express myself in three languages, a…
Seeing a lot of people getting into tiled and scrolling window managers.
I actually like my desktop with overlapping windows and being a bit in a chaotic state and slightly different all the time.
My brain needs some variety and breaks from orderly processes, because I'm a human being and I've evolved to work best in semi-chaotic circumstances.
Obviously you do you but I'm considering this trend at least to some degree productivity wankery.
Neuroscientists Studied More Than 80,000 People and Found That Speaking Multiple Languages Might Slow Down Brain Aging
https://www.smithsonianmag.com/smart-news/neurosc…
A scientifically important fMRI study of a deceased salmon won an IgNobel Prize a while back. It’s still important.
Bennett et al. "Neural Correlates of Interspecies Perspective Taking in the Post-Mortem Atlantic Salmon: An Argument For Proper Multiple Comparisons Correction" Journal of Serendipitous and Unexpected Results, 2010
There are good TV/video creations and then there are the truly awful ones that destroy brain cells.
I am wondering when Hulu will begin promoting a brain-cell-burning show about "The Real AIs of Santa Clara"?
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
What I mean by that is I doubt there is even one single truly “neurotypical” person on this Earth whose brain is actually average in every important dimension of brain variation.
2/
To flexibly organize thought, the brain makes use of space https://news.mit.edu/2026/to-flexibly-organize-thought-the-brain-makes-use-of-space-0120
Paradromics says it received FDA approval for a human trial of its Connexus brain implant, aimed at restoring speech to those with severe motor impairments (Emily Mullin/Wired)
https://www.wired.com/story/paradromics-gets-fda-approval-to-trial-…
Basically, all brain implants aimed at restoring vision to the blind are just moonshot projects that challenge technological progress which will next shift to other, broader application fields to find commercially viable markets. https://chatgpt.com/share/695245f9-9c78-8004-bf95-d7f…
“How can one mutation cause such different effects?”
Pera explained. “It comes down to genetic background.
Each strain has a unique genetic makeup that can either protect against or magnify the impact of that mutation.”
To confirm these findings in living organisms, Pera introduced the same mutations into live mice from the same eight strains.
Remarkably, the neurons in the brains of these mice phenotypically matched what he had seen in the petri dish,
providin…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Your Brain Doesn’t Magically Finish Developing at 25. Here’s What Actually Happens
https://scitechdaily.com/your-brain-doesnt-magically-finish-developing-at-25-heres-what-actually-happens/
Developers of invasive visual prostheses for the blind (brain implants, retinal implants) try to protect their turf by ignoring noninvasive alternatives based on smart glasses, using outdated and restrictive definitions, from ivory towers https://www.youtube.com/watch?v=PewuFviiSsQ
“If a pregnant person, due to head injury or illness is brain-dead, on a ventilator, their organs will keep functioning for the duration of the pregnancy. Once the baby is delivered, the normal cascade of organ failure will begin. The baby’s brain seems to be producing something that sustains the organ of the mother. What that something is, is unknown.”
Replaceable You, Mary Roach. #bookstodon
Boston-based Neurable, which builds an OS for brain-computer interfaces, raised a $35M Series A led by Spectrum Moonshot Fund, bringing its total raised to $65M (Brock E.W. Turner/Axios)
https://www.axios.com/pro/health-tech-deals/2025/12/19/neurable-r…
🧠 Decoded circuits reveal how brain cell networks stabilize memory formation
#brain
#LaVCa: LLM-assisted visual cortex captioning https://arxiv.org/abs/2502.13606 using "large language models (LLMs) to generate natural-language captions for images to which voxels are selective"; to be presented a…
cintestinalis: Tadpole larva brain (C. intestinalis)
Entire connectivity matrix for the complete brain of a larva of Ciona intestinalis. Each directed edge represents a synaptic connection from pre-synaptic cell i to post-synaptic cell j (may not be a neuron). Edge weights represent the cumulative depth of presynaptic contacts in µm.
This network has 205 nodes and 2903 edges.
Tags: Biological, Connectome, Weighted
I want to emphasize: the graphic details of what ICE did this morning are •extremely• disturbing. It is important to know what is happening, but that does not necessarily mean having every traumatic detail burned into your brain. Please take care of yourself, and be mindful of how you absorb details as they emerge.
🐭 High-speed imaging tracks live brain cell activity in awake mice
#brain
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
A look at Cybathlon, an event by ETH Zurich where researchers team up with people with disabilities in a competition to test brain-computer interfaces (Oliver Whang/New York Times)
https://www.nytimes.com/2025/11/12/scien…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
A body made entirely of head-like organs
Using state-of-the-art single-cell and gene expression analyses, the researchers mapped the cell types of young post-metamorphic sea urchins.
They found that the adult body plan is largely "head-like."
Genes that in other animals define trunk structures are active only in internal organs such as the gut and the water vascular system.
In sea urchins, a true trunk region is missing altogether.
An 'all-body brain&…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
WIRED: Sam Altman’s new brain venture, Merge Labs, will spin out of a nonprofit, Forest Neurotech https://www.wired.com/story/sam-altman-brain-computer-interface-merge-labs-spin-out-nonprofit-forest-neurotech/ Focus on usin…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Brain stimulation improves vision recovery after stroke #noninvasive cf-tACS to …
🤯 Brain activity goes to extremes in soccer fans, neuroimaging reveals
#sports
Doctors made a custom CRISPR therapy to treat an infant with a rare genetic disease
A baby, named KJ, was born with a deficiency in carbamoyl phosphate synthetase 1 (CPS1).
This deficiency means his liver couldn’t convert ammonia
– which is made naturally when the body breaks down proteins
– into urea, damaging his brain and liver.
Babies born with CPS1 deficiency often end up staying in the hospital until they’re eligible for a liver transplant.
They h…
WIRED: #Paradromics gets FDA approval to trial its brain implant in people https://www.wired.com/story/paradromics-gets-fda-approval-to-trial-its-brain-impla…
🥓 Brain health could be improved with high-fat, low-carb diet, study finds
#brain
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Amid talk of a brain drain, some scientists leave U.S. behind https://www.statnews.com/2025/12/17/research-cuts-fuel-scientific-brain-drain-american-science-shattered/ "A large part of what we loved about the United States i…
Donald Trump sounded like a fascist dictator
suffering from a brain bleed
during his speech yesterday
at Davos.
It was a national embarrassment
even by the lowly standards of modern American politics.
The president’s showing in Switzerland was so shabby that I feel compelled to share some thoughts about it.
First of all, despite what cable news chyrons would have you believe,
Trump’s screed was chillingly aggressive.
He began the Gree…
Lego unveils the Smart Play platform, with a brick powered by a custom chip that connects to compatible minifigures and tags for interactive lights and sounds (Jeremy White/Wired)
https://www.wired.com/story/lego-smart-brick-new-digital-brain/
IEEE Spectrum: These hearing aids will tune in to your brain #BCI
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
👁️ Natural brain opioids help us 'see the bigger picture' after rewards
#bran
cintestinalis: Tadpole larva brain (C. intestinalis)
Entire connectivity matrix for the complete brain of a larva of Ciona intestinalis. Each directed edge represents a synaptic connection from pre-synaptic cell i to post-synaptic cell j (may not be a neuron). Edge weights represent the cumulative depth of presynaptic contacts in µm.
This network has 205 nodes and 2903 edges.
Tags: Biological, Connectome, Weighted
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 121755 edges.
Tags: Biol…
ChatGPT about a Neuralink Blindsight brain implant for people born blind: "For early-blind people, a Neuralink-style cortical visual prosthesis is very unlikely to be meaningfully available in the 2020s or 2030s." https://chatgpt.com/share/694e5e8a-ee78-8004-91fc-9ed48e261…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Revolutionary 65,536-electrode wireless brain-computer interface #BCI
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 121755 edges.
Tags: Biol…
Neuralink set to launch 'high-volume' brain implant production as competitors weigh in https://thedebrief.org/neuralink-set-to-launch-high-volume-brain-implant-production-as-competitors-weigh-in/
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Vivani subsidiary Cortigent to present Orion Visual Cortical Prosthesis System at NANS 2026, January 23, 2026 https://finance.yahoo.com/news/vivani-subsidiary-cortigent-present-orion-120000709.html 60 cortical surface electrodes, based on Argus II…
Wireless device uses light patterns to deliver information directly to the brain https://medicalxpress.com/news/2025-12-wireless-device-patterns-brain.html
Patterned wireless transcranial optogenetics generates artificial perception (in mice)
fly_hemibrain: Fly hemibrain (2020)
A synaptic map of the hemibrain connectome of fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using EM reconstruction techniques. Neurons are labeled by their type. Edges are annotated by the connection strength between the neurons.
This network has 21739 nodes and 4259624 edges.
Tags: Biological, Connectome, Weighted, Metadata
Can a visual neuroprosthesis communicate with the brain? https://www.medscape.com/viewarticle/can-visual-neuroprosthesis-communicate-brain-2025a1000yhe Archived at
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 80270 edges.
Tags: Biolo…
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 71604 edges.
Tags: Biolo…