@Speckdaene@nrw.social2026-06-21 17:18:49
21.6., 20h: Spontandemo in #Dortmund. Solidarität mit dem Verletzten Göttinger #Antifa. #nonazisdo
@chpietsch@fedifreu.de2026-07-20 16:23:15
Der #Antifanstalt-Skandal ist hörenswert. Vielen Dank fürs Ausgraben, @…
@davej@dice.camp2026-07-20 21:28:28
Were I rich enough to understand—and afford—lettuce futures, I’d be very excited about this #AndyBurnham chap.
#ukpol
@juer@juergenklute@digitalcourage.social2026-07-20 07:45:53
@anneroth@systemli.social2026-09-20 13:45:34
Mein Kommentar:
"Es kostet Überwindung, sich angesichts von Terrorismusvorwürfen an die Seite der Betroffenen zu stellen. Ich weiß das.
Die „Chilling Effects“, also das Schweigen und der Rückzug der vielen anderen, die sich gut überlegen, ob sie sich weiter sichtbar kritisch äußern, ist ein Ziel solcher Vorwürfe gegen politisch Andersdenkende.
Wen Trump meint, ist offensichtlich: Linke, Antifaschist*innen, LGBTIQ, Feminist*innen und noch viele andere."
@qurlyjoe@mstdn.social2026-06-21 20:52:55
Breaking: The FBI has found suitcases full of algae spores at ANTIFA headquarters. Film at 11.
@arXiv_physicsinsdet_bot@mastoxiv.page2026-08-21 08:05:53
Nanoscale silicon sensor - guided new insights into early metabolic response of Escherichia coli to ampicillin
Yingtao Yu, Victoria Nolan, Zheqiang Xu, Allison Jones, George Alhoush, Zhen Zhang, Sanna Koskiniemi
https://arxiv.org/abs/2608.20014 https://arxiv.org/pdf/2608.20014 https://arxiv.org/html/2608.20014
arXiv:2608.20014v1 Announce Type: new
Abstract: Antibiotic killing is often attributed to inhibition of specific cellular targets, yet metabolic processes can strongly influence drug efficacy. However, the relationship between metabolic responses and antibiotic lethality remains incompletely understood. Here, we employed silicon nanowire field-effect transistor (SiNWFET) sensors to monitor real-time metabolic responses of Escherichia coli to ampicillin (AMP). AMP treatment induced a biphasic extracellular pH signature, characterized by rapid acidification followed by alkalization. Metabolomic analyses revealed that the initial acidification resulted from organic acid secretion, whereas the subsequent alkalization was associated with altered amino acid metabolism and formate flux. Using metabolic and respiratory mutants, we found that these extracellular signatures reflected pathway-specific metabolic rewiring that predicted bacterial killing. AMP lethality strongly correlated with ATP dynamics and formate secretion: strains exhibiting larger AMP-induced ATP increases and greater formate secretion showed enhanced susceptibility. In contrast to literature, changes in NADH and NADPH levels did not support redox stress as the primary bacterial-killing mechanism. Together, our findings identify formate metabolism as a key pathway underlying the elevated ATP levels associated with AMP bactericidal activity. These results demonstrate that SiNWFET sensors provide a versatile label-free tool for probing antibiotic mechanisms, rapidly assessing bacterial susceptibility, and potentially guiding antimicrobial therapy development.
toXiv_bot_toot
@thijs_lucas@norden.social2026-07-21 08:40:52
Ach schau an. Die CDU schickt Leute zu Trumps Wahlkampfveranstaltung - aber nicht die eigenen, sondern verbeamtete Staatsdiener: https://taz.de/US-Konferenz-mit-Marco-Rubio/!6196349/
Die Trump Regierung unterstützt offen die rechtsextreme AfD und die CDU schleimt sich bei Tr…
@ascendor@social.tchncs.de2026-07-20 10:26:34
@Speckdaene@nrw.social2026-07-19 15:24:11