It has belatedly emerged that a 6-year-old girl in China who had a rare genetic disease
died a week after receiving the world's first brain gene-editing treatment.
The researchers released animal test results in the international journal Nature this year ahead of the treatment,
but did not disclose the already conducted clinical trial and the patient's death in the paper.
The international journal Science and the research-ethics outlet Retraction Watch reported…
multi-trillion dollar company showing off their multi-trillion dollar PhD-level galaxy brain technology
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 112890 edges.
Tags: Biol…
A geometry aware framework enhances noninvasive mapping of whole human brain dynamics
Song Wang, Kexin Lou, Chen Wei, Zhiyuan Sheng, Jiahao Tang, Kaining Peng, Xinke Shen, Shuhao Mei, Liang Chen, Dongfeng Gu, Quanying Liu
https://arxiv.org/abs/2604.25592 https://arxiv.org/pdf/2604.25592 https://arxiv.org/html/2604.25592
arXiv:2604.25592v1 Announce Type: new
Abstract: Non-invasive electrophysiology lacks methods that accurately reconstruct whole-brain spatiotemporal dynamics while incorporating individual cortical geometry, leaving current electroencephalography and magnetoencephalography source imaging limited by simplistic or biologically implausible priors. Here, we show that embedding participant-specific Geometric Basis Functions (GBFs), eigenmodes derived from each individual's cortical surface, provides a powerful anatomic constraint that resolves the inverse problem and improves reconstruction fidelity. The method reconstructs neural sources as linear combinations of geometric basis functions, thereby aligning source estimates with the geometric organization of neural dynamics. We validate GBF across the Meta-Source Benchmark, task-evoked data, resting-state networks, intracranial stimulation, and epilepsy data. The results demonstrate that GBF yields high localization accuracy and captures fast spatiotemporal dynamics consistent with anatomical pathways. These findings suggest that both spontaneous and evoked whole-brain activity can be described by hundreds of geometric modes, providing a compact yet accurate representation of neural sources. By linking cortical geometry to electrophysiological dynamics, GBF offers a versatile source imaging tool for both scientific and clinical applications.
toXiv_bot_toot
How it feels to focus on anything for more than 30 minutes
By linking up visual and auditory processing in the human brain, The vOICe vision BCI can act as both a fully noninvasive visual prosthesis for the totally blind and as a research vehicle for macroscopic neuroscience https://www.artificialvision.com/neuralink.htm
ADHD Families Podcast
This podcast delivers practical strategies for parenting kids with ADHD, supporting executive function development, reducing overwhelm, and building systems that work with the ADHD brain...
Great Australian Pods Podcast Directory: https://www.greataustralianpods.com/adhd-f
¿Quién se va a escuchar "Brain damage" y "Eclipse" todos los días de aquí al 12 de agosto?
Brain-Computer-Interface: ALS-Patient nutzt Hirnimplantat 19 Monate lang
Ein ALS-Patient hat ein Brain-Computer-Interface fast zwei Jahre lang täglich zu Hause genutzt. Die Studie liefert wichtige Belege für die Alltagstauglichkeit.
Auf Anregung von @… habe ich mal versucht, meinen Workflow von #Logseq auf #Orgmode umzubauen.
Der erste Ansatz mit org-roam sah vielversprechend aus. Aber schon nach ku…
I check out @… every now and then but I think I just don't like the format of short videos. It's sort of a jarring experience and (nothing against loops) I don't know if it's a good thing for my brain.
Contrast that to Pixelfed where it is still images, and there is a stillness to it... it's a image, no motion, no sound, and you can stare at …
#coffeeSnob
I don't want a coffee that "notes hints of cherry and cocoa."
I want a coffee that walks into my brain, flips a table over, and says, "Get up. We have responsibilities."
one way mastodon continues to absolutely whip bluesky's ass by an order of magnitude is by having a proper edit function, which means i didn't have to delete/redraft my mastodon post because my morning brain confused robert wilson & robert anton wilson.
Yes, it is. It also has this appalling change:
Sure, I know everyone (not really) loves git now. I have a GH account. I administer a Gitlab instance.
But I *USE* Subversion. It remains the definitive repository of the ASF software I work with and it’s how my brain works for version control.
Obviously I can still use svn in a shell. Most of my changes are very small, so vi and svn are fine. However, it is sad to see
I'm not exactly sure what peptides are, but I assume it's brain worm food. :neocat_woozy:
Your brain is supplying the missing middle cherry.
In the era of #LLM psychosis, it's important to emphasize that it is fine to talk to yourself.
Your own brain is entirely capable of being a sounding board. It can provide a second and a third opinion. It can look at things from another person's perspective. It can simulate complete complex interactions. And it can do all that in the privacy of your own head, with no extra energy cost. And it can give you a deeper understanding of yourself.
You don't need chatbots for that. You don't need to lean on their nazi owners. You don't need to pay for them, you don't need to share the intimate details of your life, you don't need to burn the planet in the process. You won't get hurt accidentally, you won't get abused or blackmailed. And your brain won't leave you helpless when someone suddenly decides helping you isn't profitable.
#AI #NoAI #NoLLM
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Brain-wide distributed processing underlying natural vision and audition https://www.biorxiv.org/content/10.64898/2026.05.26.727967v1 "prefrontal cortex coordinated brain dynamics through synergistic interactions independently of sensory modality and previous sensory e…
New York-based Probook, which is building an AI operating system for home service businesses, raised a $34M Series A led by a16z and a $6M seed led by Sequoia (Lily Mae Lazarus/Fortune)
https://fortune.com/2026/06/23/excl…
Just saw that #genAI models now have a "how to protect the environment" suggestion... which suggests to use different genAI models 😇🤣🤦
You want to know the best way to save energy and protect the environment?
- do not use genAI (use your own brain, or your friends')
- while you're at it, protest all the data centers that are getting built to support all that "energy-saving"…
OH: I'm convinced in my conspiracy monkey brain that some libertarians are getting funding from the GOP & DNC to be a distraction.
#Overheard
Well, that's probably been the worst day for #Depression of the whole bloody year, but I did not get nothing done.
I finished an essay, and I think it's an important one.
https://www.
Reading an article shared by a reputable source about accessible scrollable tables and the article indicates words that relate to the code by using color-coded underlines that are not links and my brain broke before I saw all the encoded px and LTR-only styles and yeah fine whatever close tab sigh.
"Your brain is on fire."
"How could you ever know?"
"From what comes out of it... for sure..."
#humor #idiocracy #BrainOnFire
Playing Terra Nil right now, and it's funny because from the promo stuff I thought I wouldn't like it much, yet I'm enjoying myself a lot. There's definitely a game design lesson to be leaned here.
I was absolutely correct in my assessment that the game feels like it's actively trying to make suspension of disbelief as hard as possible with its completely ridiculous mechanics that make absolutely zero sense. "That's... Not how that works at all!" Is basically playing on repeat in my brain.
Furthermore, the entire technosolutionist tenor of the game rubs me very much the wrong way. This compounds with the physics- and biology-defying (or perhaps -spiting) fictional layer in cases like the convenient magical radiation-absorbing buildings so that you can reverse radiation contamination with a few simple clicks to be extremely bad politics actually...
But... The mechanics do work together quite well to make interesting puzzles with good gameplay that includes satisfying variety and challenges. The art is wonderful, and the music and audio design are spot on. The the result of each level is immensely satisfying, and the pacing is excellent.
I guess the lesson I'm taking away from this is that really solid fundamentals can triumph over an absolute cacophony of ludonarrative dissonance. That doesn't mean that in every decision between ludonarrative harmony (or just straight up believability) and neat mechanics you should compromise towards mechanics, but it reinforces the idea that if you make the mechanics enjoyable in the abstract, players (or at least, players like me) will be willing to compromise a *lot* on whether it actually makes any sense for things to work that way.
I'm still bothered by the "use technology to fix everything" politics, which prevents this game from being one I'll enthusiastically recommend, but despite myself I am having a lot of fun with it.
#GameDesign #SolarPunk
Crosslisted article(s) found for q-bio.NC. https://arxiv.org/list/q-bio.NC/new
[1/1]:
- Independent-Component-Based Encoding Models of Brain Activity During Story Comprehension
Kamya Hari, Taha Binhuraib, Jin Li, Cory Shain, Anna A. Ivanova
https://arxiv.org/abs/2604.24942 https://mastoxiv.page/@arXiv_csCL_bot/116486847293367640
toXiv_bot_toot
Great insight from @…
“I feel like if I could stay focused on one thing I could get it done faster, but on the other hand I feel like my brain knows what it's doing, and maybe it sends me on these "side-quests" for a good reason.”
Who Are The Brain Police?
Can someone explain to me how the argument “ #LLMs only produce stochastically reasonable output ” is relevant or convincing?
Like… how do you think a human brain forms a sentence? Is this a straight-forward deterministic process? Does it matter?
I use tools and processes to verify my output and so does a coding agent.
I just don't get how this is an argument that would…
Seek professional medical advice.
If it’s a metaphorical pounding of the brain, you can start the meds immediately. @… https://mastodon.social/@mcc/116982677147848319…
Neuroscientists being “surprised” that the brain doesn’t work like a computer, episode 244:
https://www.nature.com/articles/d41586-026-01554-0
budapest_connectome: Budapest Reference Connectome 3.0
A parameterizable consensus brain graph, derived from connectomes of 477 people, each computed from MRI datasets of the Human Connectome Project. Nodes are brain regions, and edges are weighted by the number of "tracks" that run between two nodes, as well as fiber length, fractional anisotropy and the number of occurrences in each of the 477 individuals.
This network has 1015 nodes and 93708 edges.
Tags: Biolo…
Ccontrast Trump’s AI Jesus post with another Trump image that came into prominence last week:
As everyone else in the room is animated by concern for the fallen man’s well-being
—they’re elevating his legs to ensure that blood is flowing to his brain
—Trump is assuming the bored-to–petulant affect he normally shows when he’s not the center of attention.
He’s standing with his arms dangling at his side with his prepared remarks open on the desk in front of him.
He’…
Relevant for brain implants? Frequency-specific effects of pulsed magnetic field on BV2 microglial cell function https://www.tandfonline.com/doi/full/10.1080/15368378.2026.2694326 "pulsed magnetic field can effectively regulate microglial phagocytosis, migration,…
China's BrainCo unveils what it says is the world's first integrated "brain-to-robot" platform that lets users control robots using an EEG headset (Minxiao Chang/South China Morning Post)
https://www.scmp.com/tech/tech-trend…
Nourish, Heal & Rise With Dr Andrea Robertson
Each week, Dr Andrea Robertson (Osteopath, Naturopath, and Nutritionist) goes deep on inflammation, hormones, gut health, perimenopause, weight, energy, and brain fog...
Great Australian Pods Podcast Directory: https://www.greataustralianpods.com/nouris
Once you realize that a Neuralink Blindsight brain implant for restoring vision will not be available for at least another decade, consider your other options more seriously.
"none of these legacy behaviours are rational. They arise out of that bundle of behaviours inherited from our two billion years of sexually selected ancestors... If our ancestors had not had these behaviours, we would not be here. Our ancestors were not, in the sense we mean here, rational... A purely rational being — a being created ab initio rational — would not have these behaviours.
No one is proposing to build an AI with a lizard brain. It won't happen."
(YouTube) Jacques Carolan — The mission to get breakthrough brain treatments to everyone #neuromodulation
Researchers at Carnegie Mellon University have shown that
bacteria can learn from past experiences,
store memories across generations
and adapt their behavior to changing environments
all without a brain or nervous system
https://www.cmu.edu…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
Some archived AI model responses to questions relating to vision for the blind, brain implants for restoring vision, visual-to-auditory sensory substitution (The vOICe) https://www.seeingwithsound.com/archive/index.html ChatGPT, Gemini, Claude, DeepSeek, Grok, Consensus, Perplexity, …
Visual field position shapes input sampling and output routing in the superior colliculus (in mice) https://www.biorxiv.org/content/10.64898/2026.05.27.728073v1 Likely nonfunctional with brain implants in V1 for restoring vision
Thalamic oscillations distinguish natural states of consciousness in humans https://www.nature.com/articles/s41562-026-02446-z Might thalamic and other oscillations also determine if experiences appear visual or from another sensory modality? Looking for brain state control for senso…
It’s been a brutal tactic deployed by local and federal law enforcement officials time and time again over the past year:
using teargas, rubber bullets and pepper spray to control protests outside ICE detention centers or during enforcement operations.
Now, a new report lays bare the scale of the use of these crowd-control weapons during
anti-immigration demonstrations across the US,
including hundreds of incidents that resulted in lasting and traumatic injuries.
…
One of the world's top centers for brain science is taking a huge gamble on a tiny, transparent fish.
The Howard Hughes Medical Institute's Janelia Research Campus near Washington, D.C., has announcedan effort to use artificial intelligence and an unusual fish called Danionella to understand how the brain controls complex behaviors like social interaction.
Janelia plans to triple the space dedicated to fish to 6,000 square feet, which will make room for thousands of new t…
fly_larva: Drosophila larva brain (2023)
A complete synaptic map of the brain connectome of the larva of the fruit fly Drosophila melanogaster. Nodes are neurons, and edges are synaptic connections, traced individually from brain image sections using three-dimensional electron microscopy–based reconstruction. Node metadata include the neuron hempisphere, hemispherical homologue, cell type, annotations, and inferred cluster. Edge metadata include the type of interaction (`'aa'`,…
cintestinalis: Tadpole larva brain (C. intestinalis)
Entire connectivity matrix for the complete brain of a larva of Ciona intestinalis. Each directed edge represents a synaptic connection from pre-synaptic cell i to post-synaptic cell j (may not be a neuron). Edge weights represent the cumulative depth of presynaptic contacts in µm.
This network has 205 nodes and 2903 edges.
Tags: Biological, Connectome, Weighted
Neuroscientists long theorized that bilingual speakers must process different languages with separate patterns of brain activity.
In a new study, however, researchers found that these patterns were more alike than had been expected.
When deciding how to make a word singular or plural, for instance,
bilingual people exhibit strikingly similar brain activity regardless of whether they are speaking in their first or second language.
“It wasn’t obvious that it was going to…
White paper and living document: Comparing The vOICe vision BCI with Neuralink Blindsight and other brain implants for restoring vision to the blind https://www.artificialvision.com/BCI.html
(YouTube video clips) Recent developments with The vOICe visual-to-auditory sensory substitution includ…
At an Arkansas school, a boy was hit by the school’s founder and attacked by classmates in a group session the founder led, prompting a complaint and her arrest.
State Money Still Flows: Despite a jail term for the school’s founder, "The Delta Institute for the Developing Brain" continues to operate and Arkansas still sends it public funds.
Unregulated and Growing: BY DESIGN, private schools get little oversight in Arkansas even as new opportunities to receive state m…
When will @… write about Elon Musk's Neuralink Blindsight brain implant? Still nothing in sight. #BCI
Seeing and imagining are handled by the same brain cells https://www.simonsfoundation.org/2026/05/12/seeing-and-imagining-are-handled-by-the-same-brain-cells/
"Researchers make advances in understanding how human brains ar…
A computer model predicted which human brain implant channels would fail #invasive
Sensory restoration via brain-computer interfaces: A unified 2×2 framework and convergence roadmap https://arxiv.org/html/2606.15091v1
"Community Siloing: Research remains siloed. Teams developing high-density invasive stimulation interfaces rarely collaborate with teams building non-invasive se…
The vOICe vision BCI is an alternative for a Neuralink Blindsight brain implant. Recent developments include a live AI depth view https://www.youtube.com/watch?v=jE3ElPNA21g, AI scene description
#Paradromics: From brain implants to neuroprosthetics | Making sense of brain-computer interface terminology https://www.paradromics.com/insights/from-brain-implants-to-neuropr…
Predicting visual mental imagery: structural and transcriptomic signatures in the human brain https://www.nature.com/articles/s42003-026-10309-6 "a distributed cortical architecture underlying VMI vividness" (VMI = visual mental imagery);
Human-machine learning boosts noninvasive brain-computer control in untrained users https://techxplore.com/news/2026-07-human-machine-boosts-noninvasive-brain.html "working on noninvasive brain-computer interfaces (BCIs) to develop technology that is…
Companies developing brain implants for restoring vision to the blind will add smartglasses to compensate for ultra-crude vision, but smartglasses offering AI scene description, real-time talking OCR and sensory substitution may render the brain implant redundant. #BCI #blindness
#MIRAGE: Robust multi-modal architectures translate fMRI-to-image models from vision to mental imagery https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.10142…
The brain's code seems to be in constant flux. Neuroscientists are baffled https://www.nature.com/articles/d41586-026-01554-0 "Neurons fire much more erratically than researchers thought." Required for "time stamping" of events for long-term memories?