Tootfinder

Cancer’s Molecular Achilles Heel: Key to Improving Cancer Treatments Discovered
https://scitechdaily.com/cancers-molecular-achilles-heel-key-to-improving-cancer-treatments-discovered/

Cancer’s Molecular Achilles Heel: Key to Improving Cancer Treatments Discovered
Ubiquitin-related enzymes USP28 and USP25 play critical roles in cell processes, but their similar structures lead to challenges in cancer treatment with current inhibitors. Research at the University of Würzburg aims to refine these inhibitors to target more specifically and reduce side effects.

Cancer’s Molecular Achilles Heel: Key to Improving Cancer Treatments Discovered
https://scitechdaily.com/cancers-molecular-achilles-heel-key-to-improving-cancer-treatments-discovered/

Cancer’s Molecular Achilles Heel: Key to Improving Cancer Treatments Discovered
Ubiquitin-related enzymes USP28 and USP25 play critical roles in cell processes, but their similar structures lead to challenges in cancer treatment with current inhibitors. Research at the University of Würzburg aims to refine these inhibitors to target more specifically and reduce side effects.

Uncovering the first-infall history of the LMC through its dynamical impact in the Milky Way halo
Yanjun Sheng, Yuan-Sen Ting, Xiang-Xiang Xue, Jiang Chang, Hao Tian
https://arxiv.org/abs/2404.08975

Uncovering the first-infall history of the LMC through its dynamical impact in the Milky Way halo
The gravitational interactions between the LMC and the Milky Way can give rise to dynamical perturbations in the MW halo, leading to a biased distribution of stellar density and other kinematic signals. These disequilibrium phenomena exhibit variations under different parameter combinations of the MW-LMC model. In this work, we run 50 high-resolution N-body simulations spanning different masses and halo shapes of the Milky Way and LMC and investigate how the LMC-induced perturbations evolve wit…

Most nearby young star clusters formed in three massive complexes: #StarClusters Originate from Only Three "Families": #AAS244 presser gone open access only belatedly. Presser #3 came only with the press releases https://natsci.msu.edu/news/2024-06-flares-and-echoes-from-the-milk-ways-monster-black-hole.aspx and https://greenbankobservatory.org/front-page-news/while-aiming-for-massive-gas-cloud-astronomers-spot-differences-in-thickness-of-milky-way-galaxy/ and no papers).

I only managed 4 miles this morning as I had to get to UPS to ship out a MIDI controller to some guy performing at Coachella.
#mke #milwaukee #biking

The oldest stars with low neutron-capture element abundances and origins in ancient dwarf galaxies: #stars in our own galactic backyard: https://news.mit.edu/2024/mit-researchers-discover-universes-oldest-stars-in-galactic-backyard-0514 - three stars circling the Milky Way’s halo formed 12 to 13 billion years ago.

Milky Way-est: Cosmological Zoom-in Simulations with Large Magellanic Cloud and Gaia-Sausage-Enceladus Analogs
Deveshi Buch, Ethan O. Nadler, Risa H. Wechsler, Yao-Yuan Mao
https://arxiv.org/abs/2404.08043

Milky Way-est: Cosmological Zoom-in Simulations with Large Magellanic Cloud and Gaia-Sausage-Enceladus Analogs
We present Milky Way-est, a suite of 20 cosmological cold-dark-matter-only zoom-in simulations of Milky Way (MW)-like host halos. Milky Way-est hosts are selected such that they: ($i$) are consistent with the MW's measured halo mass and concentration, ($ii$) accrete a Large Magellanic Cloud (LMC)-like ($\approx 10^{11}~M_{\odot}$) subhalo within the last $1.3~\mathrm{Gyr}$ on a realistic orbit, placing them near $50~\mathrm{kpc}$ from the host center at $z\approx 0$, and ($iii$) undergo a $>$1:…

I did manage to do 6 miles today in about 38 minutes. I have rode the last few days due to rain or feeling unwell in the morning. I've also been on medication that prevents me from being in the sun but this is the last day of that.
#mke #milwaukee

Milky Way-est: Cosmological Zoom-in Simulations with Large Magellanic Cloud and Gaia-Sausage-Enceladus Analogs
Deveshi Buch, Ethan O. Nadler, Risa H. Wechsler, Yao-Yuan Mao
https://arxiv.org/abs/2404.08043

Milky Way-est: Cosmological Zoom-in Simulations with Large Magellanic Cloud and Gaia-Sausage-Enceladus Analogs
We present Milky Way-est, a suite of 20 cosmological cold-dark-matter-only zoom-in simulations of Milky Way (MW)-like host halos. Milky Way-est hosts are selected such that they: ($i$) are consistent with the MW's measured halo mass and concentration, ($ii$) accrete a Large Magellanic Cloud (LMC)-like ($\approx 10^{11}~M_{\odot}$) subhalo within the last $1.3~\mathrm{Gyr}$ on a realistic orbit, placing them near $50~\mathrm{kpc}$ from the host center at $z\approx 0$, and ($iii$) undergo a $>$1:…

Effects of Halo Spin on Bar Formation in Disk Galaxies
Dajeong Jang, Woong-Tae Kim
https://arxiv.org/abs/2406.08823 https://arxiv.org…

Effects of Halo Spin on Bar Formation in Disk Galaxies
The spin of dark halos has been shown to significantly affect bar formation and evolution in disk galaxies. To understand the physical role of the halo spin on bar formation, we run $N$-body simulations of isolated, Milky Way-sized galaxies by varying the halo spin parameter in the range $-0.16 \leq λ\leq 0.16$ and the bulge mass. We find that our adopted halo \emph{alone} is subject to swing amplification of an $m=2$ non-axisymmetric mode rotating in the same sense as the halo, which assists …