Tootfinder

Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control
Hoshin Kim, Song Feng, Pavlo Bohutskyi, Xiaolu Li, Daniel Mejia-Rodriguez, Tong Zhang, Wei-Jun Qian, Margaret S. Cheung
https://arxiv.org/abs/2507.21336

Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control
Cyanobacteria require ultra-fast metabolic switching to maintain reducing power balance during environmental fluctuations. Glucose-6-phosphate dehydrogenase (G6PDH), catalyzing the rate-limiting step of the oxidative pentose phosphate pathway (OPPP), provides essential NADPH and metabolic intermediates for biosynthetic processes and redox homeostasis. In cyanobacteria, the unique redox-sensitive protein OpcA acts as a metabolic switch for G6PDH, enabling rapid adjustment of reducing power gener…

Surface Acoustic Wave Hemolysis Assay for Evaluating Stored Red Blood Cells
Meiou Song, Colin C. Anderson, Nakul Sridhar, Julie A. Reisz, Leyla Akh, Yu Gao, Angelo D'Alessandro, Xiaoyun Ding
https://arxiv.org/abs/2510.02482

Surface Acoustic Wave Hemolysis Assay for Evaluating Stored Red Blood Cells
Blood transfusion remains a cornerstone of modern medicine, saving countless lives daily. Yet the quality of transfused blood varies dramatically among donors-a critical factor often overlooked in clinical practice. Rapid, benchtop, and cost-effective methods for evaluating stored red blood cells (RBCs) at the site of transfusion are lacking, with concerns persisting about the association between metabolic signatures of stored RBC quality and transfusion outcomes. Recent studies utilizing metab…

Quantitative multi-metabolite imaging of Parkinson's disease using AI boosted molecular MRI
Hagar Shmuely (School of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel), Michal Rivlin (School of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel), Or Perlman (School of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel)

Quantitative multi-metabolite imaging of Parkinson's disease using AI boosted molecular MRI
Traditional approaches for molecular imaging of Parkinson's disease (PD) in vivo require radioactive isotopes, lengthy scan times, or deliver only low spatial resolution. Recent advances in saturation transfer-based PD magnetic resonance imaging (MRI) have provided biochemical insights, although the image contrast is semi-quantitative and nonspecific. Here, we combined a rapid molecular MRI acquisition paradigm with deep learning based reconstruction for multi-metabolite quantification of gluta…