Tootfinder

mission of burma's roger miller at the francis kite club in #nyc, as a solo electric #guitar ensemble (2 prepared lap steels, 6-string, & many pedals), playing music scored/charted to follow the structures of his dreams. cascading & gorgeous.

Diversity by Design: Addressing Mode Collapse Improves scRNA-seq Perturbation Modeling on Well-Calibrated Metrics
Gabriel M. Mejia, Henry E. Miller, Francis J. A. Leblanc, Bo Wang, Brendan Swain, Lucas Paulo de Lima Camillo
https://arxiv.org/abs/2506.22641

Diversity by Design: Addressing Mode Collapse Improves scRNA-seq Perturbation Modeling on Well-Calibrated Metrics
Recent benchmarks reveal that models for single-cell perturbation response are often outperformed by simply predicting the dataset mean. We trace this anomaly to a metric artifact: control-referenced deltas and unweighted error metrics reward mode collapse whenever the control is biased or the biological signal is sparse. Large-scale \textit{in silico} simulations and analysis of two real-world perturbation datasets confirm that shared reference shifts, not genuine biological change, drives hig…