
Pairwise Rearrangement is Fixed-Parameter Tractable in the Single Cut-and-Join Model
Genome rearrangement is a common model for molecular evolution. In this paper, we consider the Pairwise Rearrangement problem, which takes as input two genomes and asks for the number of minimum-length sequences of permissible operations transforming the first genome into the second. In the Single Cut-and-Join model (Bergeron, Medvedev, & Stoye, J. Comput. Biol. 2010), Pairwise Rearrangement is $\#\textsf{P}$-complete (Bailey, et. al., COCOON 2023), which implies that exact sampling is intracta…