Tootfinder

Guided Generation for Developable Antibodies
Siqi Zhao, Joshua Moller, Porfi Quintero-Cadena, Lood van Niekerk
https://arxiv.org/abs/2507.02670 https://

Guided Generation for Developable Antibodies
Therapeutic antibodies require not only high-affinity target engagement, but also favorable manufacturability, stability, and safety profiles for clinical effectiveness. These properties are collectively called `developability'. To enable a computational framework for optimizing antibody sequences for favorable developability, we introduce a guided discrete diffusion model trained on natural paired heavy- and light-chain sequences from the Observed Antibody Space (OAS) and quantitative developa…

A new source of natural antibiotics hidden within our own proteins
https://phys.org/news/2025-06-source-natural-antibiotics-hidden-proteins.html

HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3
Jie Gao, Jing Hu, Shanzhuo Zhang, Kunrui Zhu, Sheng Qian, Yueyang Huang, Xiaonan Zhang, Xiaomin Fang
https://arxiv.org/abs/2507.02345

HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3
Antibody engineering is essential for developing therapeutics and advancing biomedical research. Traditional discovery methods often rely on time-consuming and resource-intensive experimental screening. To enhance and streamline this process, we introduce a production-grade, high-throughput platform built on HelixFold3, HelixDesign-Antibody, which utilizes the high-accuracy structure prediction model, HelixFold3. The platform facilitates the large-scale generation of antibody candidate sequence…

Är @… de enda som skriver om den här demon? https://www.etc.se/inrikes/antivaxxare-och-naziveter…

Extremt nätverk bakom aktion mot Bilderberg: ”Framtiden tillhör oss”
Här är männen och kvinnorna bakom marschen mot “globalisterna”.

#Antifa Die #SPD im #LTNRW hatte eine kleine Anfrage gestellt zu "Rechtsextremen Terrorgruppen auf Telegram – was unternimmt die Landesregierung"?

ARB inactivation, ARGs and antibiotics degradation in hospital wastewater
Kornelia Stefaniak, Monika Harnisz, Magdalena Mecik, Ewa Korzeniewska
https://arxiv.org/abs/2506.03630

ARB inactivation, ARGs and antibiotics degradation in hospital wastewater
Antibiotic resistance (AR) is one of the greatest public health challenges worldwide. Processes that allow the reduction of AR predictor of hospital wastewater has become crucial process that contributes to the protection of public health and the environment. The aim of this review article was to compare the effectiveness of various methods for treatment hospital wastewater in eliminating antibiotic-resistant bacteria (ARB) and degrading antibiotic resistance genes (ARGs) and antibiotics. A lar…

Ultrafast switching of photoinduced phonon chirality in the antiferrochiral BPO$_{4}$ crystal
Hao Chen, Hanyu Wang, Tingting Wang, Yongsen Tang, Haoshu Li, Xiaohong Yan, Lifa Zhang
https://arxiv.org/abs/2506.03742

Ultrafast switching of photoinduced phonon chirality in the antiferrochiral BPO$_{4}$ crystal
In crystalline systems, chiral crystals cannot interconvert to their enantiomorph post-synthesis without undergoing melting-recrystallization processes. However, recent work indicates that ultrafast terahertz-polarized light has been shown to enable dynamic control of structural chirality in the antiferrochiral boron phosphate (BPO$_4$) crystal. Here, using first-principles calculations and nonlinear phonon dynamics simulations, we investigate the underlying physics of lattice dynamics in this …

Integrating computational detection and experimental validation for rapid GFRAL-specific antibody discovery
Maria Francesca Abbate, Pierre Toxe, Nicolas Maestrali, Marie Gagnaire, Emmanuelle Vigne, Melody A. Shahsavarian, Thierry Mora, Aleksandra M. Walczak
https://arxiv.org/abs/2506.01995…

Integrating computational detection and experimental validation for rapid GFRAL-specific antibody discovery
The identification and validation of therapeutic antibodies is critical for developing effective treatments for many diseases. We present a computational approach for identifying antibodies targeting GFRAL-specific receptors, receptors implicated in appetite regulation. Using humanized Trianni mice, we conducted a longitudinal study with repeated blood sampling and splenic analysis. We applied the STAR computational method for antibody discovery on bulk antibody repertoire data sampled at key t…

Tunable magnons in a dual-gated 2D antiferromagnet
Nele Stetzuhn, Abhijeet M. Kumar, Sviatoslav Kovalchuk, Denis Yagodkin, Louis Simon, Samuel Ma\~nas-Valero, Eugenio Coronado, Takashi Taniguchi, Kenji Watanabe, Deepika Gill, Sangeeta Sharma, Piet Brouwer, Clemens von Korff Schmising, Stefan Eisebitt, Kirill I. Bolotin
https://a…

Tunable magnons in a dual-gated 2D antiferromagnet
The layered antiferromagnet CrSBr features magnons coupled to other quasiparticles, including excitons and polaritons, enabling their easy optical accessibility. In this work, we investigate the tunability of magnons in few-layered devices in response to changes in carrier density and the application of a perpendicular electric field. We demonstrate an on-chip tunability of the in- and out-of-phase magnon frequencies by up to 2 GHz. While the frequencies of both modes increase with the electron…

Hybrid antiferroelectric-ferroelectric domain walls in noncollinear antipolar oxides
Ivan N. Ushakov, Mats Topstad, Muhammad Z. Khalid, Niyorjyoti Sharma, Christoph Grams, Ursula Ludacka, Jiali He, Kasper A. Hunnestad, Mohsen Sadeqi-Moqadam, Julia Glaum, Sverre M. Selbach, Joachim Hemberger, Petra Becker, Ladislav Bohat\'y, Amit Kumar, Jorge \'I\~niguez-Gonz\'alez, Antonius T. J. van Helvoort, Dennis Meier

Hybrid antiferroelectric-ferroelectric domain walls in noncollinear antipolar oxides
Antiferroelectrics are emerging as advanced functional materials and are fertile ground for unusual electric effects. For example, they enhance the recoverable energy density in energy storage applications and give rise to large electromechanical responses. Here, we demonstrate noncollinearity in dipolar order as an additional degree of freedom, unlocking physical properties that are symmetry-forbidden in classical antiferroelectrics. We show that noncollinear order of electric dipole moments i…