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PRIME-SVR: Physics-infoRmed Implicit Multi-Echo Slice-to-Volume Reconstruction for Fetal T2 mapping
Busra Bulut, Maik Dannecker, Thomas Sanchez, Sara Neves Silva, Steven Jia, Jean-Baptiste Ledoux, Leo Pomar, Joanna Sichitiu, Yvan Gomez, Meriam Koob, Vincent Dunet, Maria Deprez, Guillaume Auzias, Francois Rousseau, Jana Hutter, Daniel Rueckert, Meritxell Bach Cuadra
https://arxiv.org/abs/2607.20136 https://arxiv.org/pdf/2607.20136 https://arxiv.org/html/2607.20136
arXiv:2607.20136v1 Announce Type: new
Abstract: Slice-to-volume reconstruction (SVR) is the standard method for obtaining high-resolution (HR) 3D fetal brain volumes from motion-corrupted 2D MRI slice stacks acquired in multiple orientations. Existing SVR methods are optimized and validated only for clinical-range echo times (TEs), limiting their use at non-clinical TEs and making them incompatible with quantitative T2 mapping, a protocol- and center-independent biomarker of fetal brain maturation requiring HR reconstructions across multiple TEs. We present PRIME-SVR, the first implicit neural representation (INR) framework for joint HR reconstruction from multi-echo MRI. A single fully connected network models a continuous function from spatial coordinates to signal intensities across TEs, while a second network estimates slice-specific acquisition degradations. Cross-TE coherence is enforced via a Bloch equation-derived regularization penalizing deviations from expected T2 decay, with adaptive weighting that strengthens coupling for degraded stacks. The method is fully self-supervised. We validate PRIME-SVR on 39 in vivo fetal acquisitions (13 subjects x 3 TEs) from two centers, two vendors, and two field strengths (1.5 T and 0.55 T). Compared to state-of-the-art SVR, PRIME-SVR improves reconstruction sharpness by 47%, anatomical accuracy by 30%, and cross-TE structural consistency by 14%. It enables reconstruction at late TEs previously inaccessible to SVR, yielding the first 0.8 mm isotropic T2 maps at 0.55 T and the first T2 maps derived from INR-based SVR. PRIME-SVR also accelerates quantitative imaging by reducing the data needed for multi-TE reconstruction, cutting acquisition from 15 to 10 minutes while keeping T2 accuracy within 1.7% in white and deep gray matter, or to 5 minutes with a mean T2 error of 2.3% for high-quality acquisitions.
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I've read Douglas Preston's "The Blasphemy" and it was pretty good.
The synopsis is that the US government has built the largest particle accelerator ever, in the remote area of Arizona, and a small team of scientists are about to get it running. However, as it is about to reach full power, they suddenly start losing output and a mysterious "greetings" appears on the main screen. Suspecting prank malware, they decide not to report it upstairs but to resolve it themselves. However, with no progress and suspiciously piling up problems, an ex-CIA operative is sent to investigate, under the cover of liaison tasked with improving the relations with the local Navajo people. On top of that, a lobbyist wanting to see their contract renewed engages with a televangelist to put some pressure on the project.
The book sets a mystery quite really, and keeps you caught in it to the very end. It's also packed with action. You get annoyed by politics, corruption and fundamentalism. You get mystified by the philosophical and theological problems. At some point, you just keep reading to see how the events unfold.
Apparently it's a part of Wyman Ford series, but the story is self-contained.
#books #bookstodon #thriller #SciFi