Tootfinder

🫘 Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments
https://medicalxpress.com/news/2025-11-caffeine-blocks-adenosine-pathway-fast.html

Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments
Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine as the critical mediator, yet adenosine receptors are the primary target of caffeine, the world's most widely consumed psychoactive substance.

Day 1/? without caffeine: I slept for half the afternoon because all the life had been drained from my body.

🇺🇦 #NowPlaying on #BBC6Music's #6MusicArtistInResidence
Tierra Whack:
🎵 Black Nails
#TierraWhack
https://caffeineworldwide.bandcamp.com/track/tierra-whack-black-nails-caffeine-worldwides-sunrise-edit
https://open.spotify.com/track/50PvTiqi0cZne4mKR7HRck

Day 2/? without caffeine: maybe I just have COVID

If it's cheap caffeine you want, go for the large #Dunkin iced
#DunkinDonuts #Coffee #Caffeine

All worry is laid to waste.
The endorphins rushing wild from the freezing water,
the music pounding through my body,
the caffeine,
the fucking ducks and the God-roiling sky
– no what-ifs,
no yeah-buts,
no what-abouts, 
no caveats, at all.
I am made happy,
and that happiness is entire and incontestable.
And all the way home, I go
— to my beautiful waking wife
– on this, the best day ever.
Love, Nick Cave

Nick Cave - The Red Hand Files - Issue #344 - Which song comes to mind when you are genuinely joyful? I mean, carefree, energy flowing, dancing, moving, kind of happy?
Dear Marianne, This morning, I got up at five, I couldn’t sleep, I’d fretted about this and I’d fretted about that. The night had played...

Remember, C sharp is harmonically equivalent to D flat!
-- Phroggy (slashdoCOLAtmail@phroggy.com minus caffeine)
(http://phroggy.com/)

Half my writing process right now is whispering ‘oh no’ as the story takes a turn I didn’t plan. The other half is anxiety-inducing levels of caffeine. #writerslife #creativeprocess #writing

Clueless Crime
2 girls who love their dogs, love coffee but most importantly, love true crime...
Great Australian Pods Podcast Directory: https://www.greataustralianpods.com/caffeine-crime-and-canines/

"Caffeinated coffee and tea could help protect you against dementia"
Wait, isn't "caffeinated coffee" just coffee? 😕
#superfluous #coffee #terminology #health #confused

I hate that I didn’t manage to get takeaway coffee before 1:00 pm so now I feel like I can’t have that level of caffeine

According to sources, today is also:
Equal Opportunity Day (aka Gettysburg Address Day and Dedication Day)
Geographic Information Systems (GIS) Day
National Blow Bagpipes Day
National Camp Day
National Carbonated Beverage with Caffeine Day (this is way too specific)
National Educational Support Professionals Day
National Macchiato Day
National Zinfandel Day
Play Monopoly Day
Women’s Entrepreneurship Day
And last, but not least, “Have …