Tootfinder

Revolutionising Antibacterial Warfare: Machine Learning and Molecular Dynamics Unveiling Potential Gram-Negative Bacteria Inhibitors
Pritish Joshi, Niladri Patra
https://arxiv.org/abs/2505.23356

Revolutionising Antibacterial Warfare: Machine Learning and Molecular Dynamics Unveiling Potential Gram-Negative Bacteria Inhibitors
Diseases caused by bacteria have been a threat to human civilisation for centuries. Despite the availability of numerous antibacterial drugs today, bacterial diseases continue to pose life-threatening challenges. The credit for this goes to Gram-Negative bacteria, which have developed multi-drug resistant properties towards \b{eta}-lactams, chloramphenicols, fluoroquinolones, tetracyclines, carbapenems, and macrolide antibiotics. V arious mechanisms of bacterial defence contribute to drug resis…