Tootfinder

Une exposition prolongée Š de faibles concentrations de PFAS peut perturber les fonctions cérébrales, endommager les neurones et altérer la mémoire et le comportement des souris, selon une récente recherche.
#PFAS

new beanytuesday politicians dont hit like og bloodfeast but ill take it

🇺🇦 #NowPlaying on #BBC6Music's #TheFirstTimeWith
Henry Cow:
🎵 Nirvana For Mice
#HenryCow
https://henrycow.bandcamp.com/track/nirvana-for-mice
https://open.spotify.com/track/5hWm1MrkIAesdqsJUTsOl1

Mouse vs. AI: A Neuroethological Benchmark for Visual Robustness and Neural Alignment
Marius Schneider, Joe Canzano, Jing Peng, Yuchen Hou, Spencer LaVere Smith, Michael Beyeler
https://arxiv.org/abs/2509.14446

Mouse vs. AI: A Neuroethological Benchmark for Visual Robustness and Neural Alignment
Visual robustness under real-world conditions remains a critical bottleneck for modern reinforcement learning agents. In contrast, biological systems such as mice show remarkable resilience to environmental changes, maintaining stable performance even under degraded visual input with minimal exposure. Inspired by this gap, we propose the Mouse vs. AI: Robust Foraging Competition, a novel bioinspired visual robustness benchmark to test generalization in reinforcement learning (RL) agents trained…

Layer-specific changes in sensory cortex across the lifespan in mice and humans #7T

Layer-specific changes in sensory cortex across the lifespan in mice and humans - Nature Neuroscience
The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep layer degeneration but that layer IV is more pronounced in old age.

ça pourrait être une bonne piste !
"Low dose of lithium reverses Alzheimer's symptoms in mice"
https://www.newscientist.com/article/2491493-low-dose-of-lithium-reverses-alzheimers-symptoms-in-mice/

Certain kinds of gut microbes absorb toxic Pfas
“forever chemicals”
and help expel them from the body via feces,
new first-of-its-kind University of Cambridge research shows.
The findings are welcome news
as the only options that exist for reducing the level of dangerous Pfas compounds from the body are bloodletting and a cholesterol drug that induces unpleasant side effects.
The microbes were found to remove up to 75% of some Pfasfrom the gut of mice.

Towards Continuous Home Cage Monitoring: An Evaluation of Tracking and Identification Strategies for Laboratory Mice
Juan Pablo Oberhauser, Daniel Grzenda
https://arxiv.org/abs/2507.07929

Towards Continuous Home Cage Monitoring: An Evaluation of Tracking and Identification Strategies for Laboratory Mice
Continuous, automated monitoring of laboratory mice enables more accurate data collection and improves animal welfare through real-time insights. Researchers can achieve a more dynamic and clinically relevant characterization of disease progression and therapeutic effects by integrating behavioral and physiological monitoring in the home cage. However, providing individual mouse metrics is difficult because of their housing density, similar appearances, high mobility, and frequent interactions.…

Too good. I had to re-repost. (And I'll keep reminding myself--it's just a #JOKE.)

Encoding visual stimuli by striatal neurons (in mice) https://www.biorxiv.org/content/10.1101/2025.09.15.676378v1 "Although visual object encoding is considered a cortical attribute, subcortical areas also contain visual processing circuits."

Causal Emergence of Consciousness through Learned Multiscale Neural Dynamics in Mice
Zhipeng Wang, Yingqi Rong, Kaiwei Liu, Mingzhe Yang, Jiang Zhang, Jing He
https://arxiv.org/abs/2509.10891

Causal Emergence of Consciousness through Learned Multiscale Neural Dynamics in Mice
Consciousness spans macroscopic experience and microscopic neuronal activity, yet linking these scales remains challenging. Prevailing theories, such as Integrated Information Theory, focus on a single scale, overlooking how causal power and its dynamics unfold across scales. Progress is constrained by scarce cross-scale data and difficulties in quantifying multiscale causality and dynamics. Here, we present a machine learning framework that infers multiscale causal variables and their dynamics…

🧠 Brain-enriched microRNA shows promise for protecting neurons in depression
https://medicalxpress.com/news/2025-07-brain-enriched-microrna-neurons-depression.html

Brain-enriched microRNA shows promise for protecting neurons in depression
A Henan University of Science and Technology team reports that boosting miR-542-3p thwarts stress-related cell loss in the hippocampus and eases depressive-like behavior in mice.

Wheel running in the wild | Proceedings of the Royal Society B: Biological Sciences
#mice #slugs #nothamsters
https://royalsocietypublishing.org/doi/10.1098/rspb.2014.0210

What the f are you disgusting people doing with your mice.
@… https://social.jenna.app/@jennamagius/statuses/01K45T5W9E9VS4D5X…

Recurrent pattern completion drives the neocortical representation of sensory inference (in mice) https://www.nature.com/articles/s41593-025-02055-5 "neurons that encode sensory inference are specialized for receiving and locally broadcasting top-down information"

Recurrent pattern completion drives the neocortical representation of sensory inference - Nature Neuroscience
Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by selectively reinforcing activity patterns that match prior expectations.

Help End Cruel Sepsis Experiments on Animals #AnimalRights

Help End Cruel Sepsis Experiments on Animals
Mice and rats are cut open, their intestines punctured so that faeces leak into their bodies in ineffective experiments – urge the government to put an end to this.

Bayesian inference of antibody evolutionary dynamics using multitype branching processes
Athanasios G. Bakis, Ashni A. Vora, Tatsuya Araki, Tongqiu Jia, Jared G. Galloway, Chris Jennings-Shaffer, Gabriel D. Victora, Yun S. Song, William S. DeWitt, Frederick A. Matsen IV, Volodymyr M. Minin
https://arxiv.org/abs/2508.09519

Bayesian inference of antibody evolutionary dynamics using multitype branching processes
When our immune system encounters foreign antigens (i.e., from pathogens), the B cells that produce our antibodies undergo a cyclic process of proliferation, mutation, and selection, improving their ability to bind to the specific antigen. Immunologists have recently developed powerful experimental techniques to investigate this process in mouse models. In one such experiment, mice are engineered with a monoclonal B-cell precursor and immunized with a model antigen. B cells are sampled from sac…

Beautiful work from the lab of Nik Francis, with compelling behavioral evidence for pitch perception in mice, and also for its neural representation in cortex (using widefield calcium imaging).
https://biologists.social/@biorxiv_neursci/115147861477486613

If there are two things Americans love, it’s vaccines and flossing. #sarcasm https://flipboard.com/@health/the-latest-health-news…

Future vaccines could be delivered by dental floss
Researchers tested the new method on lab mice teeth. Hypodermic needles remain the most common method of administering lifesaving vaccines, but that doesn’t mean receiving the jab has gotten more pleasant over time. Now, biomedical engineers are exploring a new approach that could ditch shots …

🇺🇦 #NowPlaying on KEXP's #MorningShow
Mo-Dettes:
🎵 White Mice
#MoDettes
https://open.spotify.com/track/6QHZjDhY00tTwJWOna8Vyb

Big M, Little M, many mumbling mice
Are making midnight music in the moonlight,
Mighty nice!

#Mouse visitor(s), episode 2:
Anyone knows how to figure out where unwanted mice visitors might be coming in from into my (basement) flat? I tried UV light but without success so far. Also tried to plug any visible hole - however small - but they keep coming. I'd like to know for sure where they come from. Pour flour on the floor to try and detect their paw traces?
(I don't want to kill…

Amputation-imputation based generation of synthetic tabular data for ratemaking
Yevhen Havrylenko, Meelis K\"a\"arik, Artur Tuttar
https://arxiv.org/abs/2509.02171 htt…

Amputation-imputation based generation of synthetic tabular data for ratemaking
Actuarial ratemaking depends on high-quality data, yet access to such data is often limited by the cost of obtaining new data, privacy concerns, etc. In this paper, we explore synthetic-data generation as a potential solution to these issues. In addition to discussing generative methods previously studied in the actuarial literature, we introduce to the insurance community another approach based on Multiple Imputation by Chained Equations (MICE). We present a comparative study using an open-sou…

Conference vignette 👀: #OpenScience is about much more than #OpenData. Presenting unpublished work is also Openness, as social science alumna Dr. Ros Attenborough reminded us. And if you can share that way, then...
In the Presidential symposium, another lab alumnus introduced a mouse protein that massively affected the clock ⏰ . His group found it through an ambitious phosphoproteomic 🧪 candidate selection approach on a cell line 🧫 , looking beyond the canonical idea of the clockwork (TTFL in the jargon). Canonical here means canonised by a Nobel prize.
A good friend from Japan explained in the Q&A that his group had just found the SAME gene in a genetic screen of mice 🐁with altered sleep patterns 🐁💤🛌. We know the clock controls sleep. So, independent evidence across continents.👍
Over dinner they started to coordinate how they would each publish their work. #Science working.

A robust and versatile deep learning model for prediction of the arterial input function in dynamic small animal $\left[^{18}\text{F}\right]$FDG PET imaging
Christian Salomonsen, Luigi Tommaso Luppino, Fredrik Aspheim, Kristoffer Wickstr{\o}m, Elisabeth Wetzer, Michael Kampffmeyer, Rodrigo Berzaghi, Rune Sundset, Robert Jenssen, Samuel Kuttner
https:…

A robust and versatile deep learning model for prediction of the arterial input function in dynamic small animal $\left[^{18}\text{F}\right]$FDG PET imaging
Dynamic positron emission tomography (PET) and kinetic modeling are pivotal in advancing tracer development research in small animal studies. Accurate kinetic modeling requires precise input function estimation, traditionally achieved via arterial blood sampling. However, arterial cannulation in small animals like mice, involves intricate, time-consuming, and terminal procedures, precluding longitudinal studies. This work proposes a non-invasive, fully convolutional deep learning-based approach…

Visual objects refine head direction coding (in mice) #neuroscience

Panic, Terror, and Near Drowning: Ban the Forced Swim Test #AnimalRights

Panic, Terror, and Near Drowning: Ban the Forced Swim Test
Pharma giant Novartis supports putting mice and rats in water-filled containers from which they desperately try to escape.

A supercharged HIV vaccine could offer strong protection with just one injection, a study in mice has indicated.
Developed by researchers from the Massachusetts Institute of Technology (MIT) and the Scripps Research Center, the vaccine includes two "adjuvants"
—materials that help stimulate the immune system response.
In the experiments, the dual-adjuvant vaccine was found to produce a wider diversity of antibodies to protect against an HIV protein than with either s…

HIV: Supercharged Vaccine Could Protect Well With Just One Dose
The approach employed by the research team could be used against other diseases—including COVID-19 and influenza.

Be sure to take your vitamins! https://pubmed.ncbi.nlm.nih.gov/40628762/

#monsterdon alert: Super Mice!
What. Could. Possibly. Go. Wrong.
https://www.nature.com/articles/d41586-025-01898-z

Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice
Ana Dudas (PRC), Ana Novak (CBM), Caroline Gora (PRC), Emmanuel Pecnard (PRC), Nicolas Azzopardi (PRC), S\'everine Morisset-Lopez (CBM), Lucie P. Pellissier (PRC)
https://arxiv.org/abs/2507.19220

Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice
Preclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability. This limitation hampers the modeling of phenotypic heterogeneity, characteristic of these conditions. Recent efforts have explored the use of multiple genetically diverse hybrid strains to address this. In this study, we examined whether one single mixed genetic mouse background, C57BL/6J;129S2/SvPas (B6;129), could …

@… wireless mice should be called hamsters!

Topographic alignment of auditory inputs to the visual cortex (in mice) https://www.biorxiv.org/content/10.1101/2025.07.29.667237v1 More information in the Bluesky thread

The Sex-Dependent Effects of Psychedelics on Myelination in APOE4 Mice
Sanjana Shankar
https://arxiv.org/abs/2506.17293 https://arxiv…

The Sex-Dependent Effects of Psychedelics on Myelination in APOE4 Mice
Several studies have linked myelin abnormalities with neuropsychiatric disorders; others have implicated psychedelics as a potential therapeutic for such conditions. One risk factor for these demyelinating disorders is a mutation in the Apolipoprotein E gene known as APOE4. This variant impedes the cholesterol regulation of oligodendrocytes responsible for the myelination, or insulation, of neurons when compared to the wild-type phenotype. In this work, I advance knowledge of cellular pathways …

Recursive Equations For Imputation Of Missing Not At Random Data With Sparse Pattern Support
Trung Phung, Kyle Reese, Ilya Shpitser, Rohit Bhattacharya
https://arxiv.org/abs/2507.16107

Recursive Equations For Imputation Of Missing Not At Random Data With Sparse Pattern Support
A common approach for handling missing values in data analysis pipelines is multiple imputation via software packages such as MICE (Van Buuren and Groothuis-Oudshoorn, 2011) and Amelia (Honaker et al., 2011). These packages typically assume the data are missing at random (MAR), and impose parametric or smoothing assumptions upon the imputing distributions in a way that allows imputation to proceed even if not all missingness patterns have support in the data. Such assumptions are unrealistic in…

Multiplexed subspaces route neural activity across brain-wide networks (in mice)  https://www.nature.com/articles/s41467-025-58698-2 but no, subspace communication is not faster-than-light, sorry Star Trek fans.

Multiplexed subspaces route neural activity across brain-wide networks - Nature Communications
How the brain flexibly engages different networks of regions to perform different cognitive processes remains unknown. Here, the authors show changing the geometry of a neural representation to align with different subspaces within a brain region can engage different brainwide networks.

🇺🇦 #NowPlaying on #BBC6Music's #AmyLamé
Mo-Dettes:
🎵 White Mice
#MoDettes
https://open.spotify.com/track/6QHZjDhY00tTwJWOna8Vyb