Tootfinder

🐛 Scientists discover how caterpillars can stop their bleeding in seconds
#bugs

Scientists discover how caterpillars can stop their bleeding in seconds
Blood is a remarkable material: it must remain fluid inside blood vessels, yet clot as quickly as possible outside them, to stop bleeding. The chemical cascade that makes this possible is well understood for vertebrate blood. But hemolymph, the equivalent of blood in insects, has a very different composition, being notably lacking in red blood cells, hemoglobin, and platelets, and having amoeba-like cells called hemocytes instead of white blood cells for immune defense.

"Hydrogen fuel cells and eliminating ‘forever chemicals’: Ofwat allocates fresh tranche of green innovation funding"
#UK #UnitedKingdom #ForeverChemicals

Hydrogen fuel cells and eliminating ‘forever chemicals’: Ofwat allocates fresh tranche of green innovation funding
Next-gen hydrogen fuel cells and a technology that could ‘zap’ away forever chemicals are among the innovations which UK water regulator Ofwat is financially supporting in the hopes of reducing the industry’s environmental footprint.

Oh it might help if they actually used female cells to study 🙄: 4 out of 5 autoimmune diseases patients are women, and scientists want to know why
“For several [ever!] decades, we've used a male cell line as the standard of reference," Chan says
Here’s the study https://www.cell.com/ce…

Enhancing Robot Navigation Efficiency Using Cellular Automata with Active Cells
Saleem Alzoubi, Mahdi H. Miraz
https://arxiv.org/abs/2404.01885 https://

Enhancing Robot Navigation Efficiency Using Cellular Automata with Active Cells
Enhancing robot navigation efficiency is a crucial objective in modern robotics. Robots relying on external navigation systems are often susceptible to electromagnetic interference (EMI) and encounter environmental disturbances, resulting in orientation errors within their surroundings. Therefore, the study employed an internal navigation system to enhance robot navigation efficacy under interference conditions, based on the analysis of the internal parameters and the external signals. This art…

Double-stranded RNA activated caspase oligomerizer ( #DRACO ) technology, is an approach to ♦️selectively killing cells in which viral replication is taking place. ♦️
DRACO offered the promise of being broadly and rapidly effective for 🔸ending infection by many different viruses, and doing so with little adaptation of the core technology from virus to virus,🔸 a big improvement over the present state of…

This drug could be a game-changer for the human race
There are thousands of viruses in our world. But only about 220 are known to infect humans. Most people don’t understand how viruses work. They are not living things. They are very tiny packages of organic chemistry that get into an animal cell and...

We have another publication thingy!
It's about how cancer cells (specifically mouse 4T1 breast cancer cells) need oxidative phosphorylation to create tumours and metastasise, but only the smallest drop of energy is needed for that.
This made it a difficult metabolic process for us to study, because most gene knockout mutants are incomplete knockouts, and a few contaminating energy producers quickly overwhelm a less competent cell population.

Frontiers | Residual OXPHOS is required to drive primary and metastatic lung tumours in an orthotopic breast cancer model
BackgroundFast adaptation of glycolytic and mitochondrial energy pathways to changes in the tumour microenvironment is a hallmark of cancer. Purely glycolyti...

How #ClimateChange is Messing up the Ocean's Biological Clock, a Potential Catastrophe
https://www.juancole.com/2024/03/biological-potential-catastrophe…

How Climate Change is Messing up the Ocean's Biological Clock, a Potential Catastrophe
By Frédéric Cyr, Memorial University of Newfoundland | - Every year in the mid-latitudes of the planet, a peculiar phenomenon known as the phytoplankton spring bloom occurs. Visible from space, spectacular large and ephemeral filament-like shades of green and blue are shaped by the ocean currents. The phytoplankton blooms are comprised of a myriad of microscopic algae cells growing and accumulating at the ocean’s surface as a result of the onset of longer days and fewer storms — ofte…

What happens when you make a deal with the devil to get research funding.
”Blood Works for Graphene Production“
https://arxiv.org/abs/2404.18045

When does Subagging Work?
Christos Revelas, Otilia Boldea, Bas J. M. Werker
https://arxiv.org/abs/2404.01832 https://arxiv.org/pdf/24…

When does Subagging Work?
We study the effectiveness of subagging, or subsample aggregating, on regression trees, a popular non-parametric method in machine learning. First, we give sufficient conditions for pointwise consistency of trees. We formalize that (i) the bias depends on the diameter of cells, hence trees with few splits tend to be biased, and (ii) the variance depends on the number of observations in cells, hence trees with many splits tend to have large variance. While these statements for bias and variance …

Emergent Simplicities in the Living Histories of Individual Cells
Charles S. Wright, Kunaal Joshi, Rudro R. Biswas, Srividya Iyer-Biswas
https://arxiv.org/abs/2404.01682

Emergent Simplicities in the Living Histories of Individual Cells
Organisms maintain the status quo, holding key physiological variables constant to within an acceptable tolerance, and yet adapt with precision and plasticity to dynamic changes in externalities. What organizational principles ensure such exquisite yet robust control of systems-level "state variables" in complex systems with an extraordinary number of moving parts and fluctuating variables? Here we focus on these issues in the specific context of intra- and intergenerational life histories of i…

new research on how covid gets into cells
We already knew that the covid virus can get into cells via the ACE2 receptor.
Some cells don't have that receptor, yet the viruses still get into them - how?
"Here, we identified the transferrin receptor (TfR) as another receptor that mediates SARS-CoV-2 entry by directly binding to the virus spike protein with high affinity."
That might sound bad - but it's good that we know! Could point to treatments.
#covid #research

Scientists have successfully created from scratch one of life’s complex ingredients, #pantetheine, which is critical for metabolism in all living cells.
This lab experiment brings us one step closer to learning how lifeless molecules produced living and breathing organisms, from single-celled algae to people.

Scientists get closer to solving chemical puzzle of the origin of life
Researchers have successfully created a compound critical for metabolism in all living cells, which is essential for energy production and regulation.

This is incredibly cool - https://newatlas.com/medical/gut-bacteria-enzyme-universal-donor-blood/
If this works, there will be less wasted blood at the blood bank, and it'll be easier to give transfusions to people with rare blood types.

Bacterial enzyme strips away blood types to create universal donor blood
Using enzymes produced by a bacteria that almost everyone has in their gut, researchers have removed the antigens from red blood cells that determine blood type, putting us within reach of producing universal donor blood.

I just found this superb article of yours, @…. Great stuff! Condolences on the passing of your collaborator, Prof. Dennett.
How to understand cells, tissues and organisms as agents with agendas | Aeon Essays

How to understand cells, tissues and organisms as agents with agendas | Aeon Essays
Biology’s next great horizon is to understand cells, tissues and organisms as agents with agendas (even if unthinking ones)

The Future of Cancer Treatment? New Approach Uses the Zika Virus To Destroy Brain Cancer Cells
https://scitechdaily.com/the-future-of-cancer-treatment-new-approach-uses-the-zika-virus-to-destroy-brain-cancer-c…

The Future of Cancer Treatment? New Approach Uses the Zika Virus To Destroy Brain Cancer Cells
The scientists found that vaccine strains of the Zika virus eradicate brain tumor cells while sparing healthy ones. Scientists from Duke-NUS Medical School (Duke-NUS) have developed a new approach using the Zika virus to destroy brain cancer cells and inhibit tumour growth, while sparing healthy ce

PrPSeg: Universal Proposition Learning for Panoramic Renal Pathology Segmentation
Ruining Deng, Quan Liu, Can Cui, Tianyuan Yao, Jialin Yue, Juming Xiong, Lining Yu, Yifei Wu, Mengmeng Yin, Yu Wang, Shilin Zhao, Yucheng Tang, Haichun Yang, Yuankai Huo
https://arxiv.org/abs/2402.19286

PrPSeg: Universal Proposition Learning for Panoramic Renal Pathology Segmentation
Understanding the anatomy of renal pathology is crucial for advancing disease diagnostics, treatment evaluation, and clinical research. The complex kidney system comprises various components across multiple levels, including regions (cortex, medulla), functional units (glomeruli, tubules), and cells (podocytes, mesangial cells in glomerulus). Prior studies have predominantly overlooked the intricate spatial interrelations among objects from clinical knowledge. In this research, we introduce a n…

Findings, published Jan. 17 in Cell Stem Cell, show that dopamine neurons infected with SARS-CoV-2 stop working and send out chemical signals that cause inflammation.
Normally, these neurons produce dopamine, a neurotransmitter that plays a role in feelings of pleasure, motivation, memory, sleep and movement.
Damage to these neurons is also connected to Parkinson’s disease.
“This project started out to investigate how various types of cells in different organs respond to …

SARS-CoV-2 infection causes dopaminergic neuron senescence
Yang and colleagues demonstrate that SARS-CoV-2 can infect hPSC-derived midbrain dopamine (DA) neurons and induce cellular senescence. Several drug candidates were identified to rescue SARS-CoV-2 infection and DA neuron senescence. Inflammation and cellular senescence were also identified in substantia nigra tissue of COVID-19 patients.

“We found #COVID-19 accelerates the presence of ‘zombie’ or senescent cells, which accumulate naturally and gradually in the brain as we get older,” says University of Queensland researcher Dr Aguado.
https://w…

Turning back the clock on brains aged by COVID-19
University of Queensland researchers have found a way to reverse a cellular process triggered by COVID-19 that contributes to premature ageing of the brain.

This https://arxiv.org/abs/2308.16332 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_mat…

A new provably stable weighted state redistribution algorithm
We propose a practical finite volume method on cut cells using state redistribution. Our algorithm is provably monotone, total variation diminishing, and GKS stable in many situations, and shuts off continuously as the cut cell size approaches a target value. Our analysis reveals why original state redistribution works so well: it results in a monotone scheme for most configurations, though at times subject to a slightly smaller CFL condition. Our analysis also explains why a pre-merging step i…

Transport of topological defects in a biphasic mixture of active and passive nematic fluids
KVS Chaithanya, Aleksandra Arda\v{s}eva, Oliver J. Meacock, William M. Durham, Sumesh P. Thampi, Amin Doostmohammadi
https://arxiv.org/abs/2405.00547

Transport of topological defects in a biphasic mixture of active and passive nematic fluids
Collectively moving cellular systems often contain a proportion of dead cells or non-motile genotypes. When mixed, nematically aligning motile and non-motile agents are known to segregate spontaneously. However, the role that topological defects and active stresses play in shaping the distribution of the two phases remains unresolved. In this study, we investigate the behaviour of a two-dimensional binary mixture of active and passive nematic fluids to understand how topological defects are tra…

Reduction of Joule Losses in Memristive Switching Using Optimal Control
Valeriy A. Slipko, Yuriy V. Pershin
https://arxiv.org/abs/2404.01507 https://

Reduction of Joule Losses in Memristive Switching Using Optimal Control
Electricity production from fossil fuels is among the main contributors to global warming. To suppress climate change, energy-efficient systems, devices, and technologies must be implemented. This study investigates strategies for minimizing Joule losses in resistive random access memory (ReRAM) cells, which are also referred to as memristive devices. The basic question that we ask is what is the optimal driving protocol to switch a memristive device from one state to another. In the case of id…

Role of stress/strain in tailoring the magnetic and transport properties of magnetic thin films and multilayers
Arun Singh Dev, Dileep Kumar
https://arxiv.org/abs/2405.00049

Role of stress/strain in tailoring the magnetic and transport properties of magnetic thin films and multilayers
Magnetic anisotropy is a fundamental property of magnetic materials that determines the alignment of the spins along the preferential direction, called the easy axis of magnetization. Magnetic polycrystalline thin films offer several advantages over magnetic epitaxial thin films because of fabrication flexibility, higher coercivity and improved magnetic stability, higher magnetoresistance (useful in magneto-resistive devices such as magnetic field sensors and MRAM cells), cost-effectiveness and…

This https://arxiv.org/abs/2404.14749 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_csLG_…

Semantic Cells: Evolutional Process to Acquire Sense Diversity of Items
Previous models for learning the semantic vectors of items and their groups, such as words, sentences, nodes, and graphs, using distributed representation have been based on the assumption that an item corresponds to one vector composed of dimensions corresponding to hidden contexts in the target. Multiple senses of an item are represented by assigning a vector to each of the domains where the item may appear or reflecting the context to the sense of the item. However, there may be multiple dis…

From cell intercalation to flow, the importance of T1 transitions
Harish P. Jain, Axel Voigt, Luiza Angheluta
https://arxiv.org/abs/2403.20100 https://

From cell intercalation to flow, the importance of T1 transitions
Within the context of epithelial monolayers, T1 transitions, also known as cell-intercalations, are topological rearrangements of cells that contribute to fluidity of the epithelial monolayers. We use a multi-phase field model to show that the ensemble-averaged flow profile of a T1 transition exhibits a saddle point structure, where large velocities are localised near cells undergoing T1 transitions, contributing to vortical flow. This tissue fluidisation corresponds to the dispersion of cells …

This https://arxiv.org/abs/2401.07278 has been replaced.
link: https://scholar.google.com/scholar?q=a

Semi-Supervised Semantic Segmentation using Redesigned Self-Training for White Blood Cells
Artificial Intelligence (AI) in healthcare, especially in white blood cell cancer diagnosis, is hindered by two primary challenges: the lack of large-scale labeled datasets for white blood cell (WBC) segmentation and outdated segmentation methods. These challenges inhibit the development of more accurate and modern techniques to diagnose cancer relating to white blood cells. To address the first challenge, a semi-supervised learning framework should be devised to efficiently capitalize on the s…

Analysis of Signal Distortion in Molecular Communication Channels Using Frequency Response
Shoichiro Kitada, Taishi Kotsuka, Yutaka Hori
https://arxiv.org/abs/2403.20029

Analysis of Signal Distortion in Molecular Communication Channels Using Frequency Response
Molecular communication (MC) is a concept in communication engineering, where diffusive molecules are used to transmit information between nano or micro-scale chemical reaction systems. Engineering MC to control the reaction systems in cells is expected for many applications such as targeted drug delivery and biocomputing. Toward control of the reaction systems as desired via MC, it is important to transmit signals without distortion by MC since the reaction systems are often triggered dependin…

You can read a profile of the Alabama chief justice that calls him “revered,” “dogged,” and “brilliant” in our leading newspaper (but I won’t link to it), or you can read the historian Heather Cox Richardson.
“In the United States, theocracy and authoritarianism go hand in hand.”

February 22, 2024
The Alabama Supreme Court on February 16, 2024, decided that cells awaiting implantation for in vitro fertilization are children and that the accidental destruction of such an embryo falls under the state’s Wrongful Death of a Minor Act. In an opinion concurring with the ruling, Chief Justice Tom Parker declared that the people of Alabama have adopted the “theologically based view of the sanctity of life” and said that “human life cannot be wrongfully destroyed without incurring the wra…

This https://arxiv.org/abs/2310.19481 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_qbi…

Spatial information allows inference of the prevalence of direct cell-to-cell viral infection
The role of direct cell-to-cell spread in viral infections - where virions spread between host and susceptible cells without needing to be secreted into the extracellular environment - has come to be understood as essential to the dynamics of medically significant viruses like hepatitis C and influenza. Recent work in both the experimental and mathematical modelling literature has attempted to quantify the prevalence of cell-to-cell infection compared to the conventional free virus route using …

While Odysseus didn't wake up after its first lunar night, #SLIM has survived its SECOND night and just sent another navigation camera image of the afternoon scene: https://twitter.com/SLIM_JAXA/status/1773162369947996297 - the Japanese lander is quite hot right now, having basked in the Sun (not illuminating its solar cells) for days.

This https://arxiv.org/abs/2404.19041 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_qbi…

Stochastic dynamics of two-compartment models with regulatory mechanisms for hematopoiesis
We present an asymptotic analysis of a stochastic two-compartmental cell proliferation system with regulatory mechanisms. We model the system as a state-dependent birth and death process. Proliferation of hematopoietic stem cells (HSCs) is regulated by population density of HSC-derived clones and differentiation of HSC is regulated by population density of HSCs. By scaling up the initial population, we show the density of dynamics converges in distribution to the solution of a system of ordinar…

Time cell-like firing in cerebellar slice (Purkinje cells) driven by slow heterogeneous synapses.
https://www.biorxiv.org/content/10.1101/2024.03.24.585592v1

Nanoscale mechanical manipulation of ultrathin SiN membranes enabling infrared near-field microscopy of liquid-immersed samples
Enrico Ba\`u, Thorsten G\"olz, Martin Benoit, Andreas Tittl, Fritz Keilmann
https://arxiv.org/abs/2404.01770

Nanoscale mechanical manipulation of ultrathin SiN membranes enabling infrared near-field microscopy of liquid-immersed samples
Scattering scanning near-field optical microscopy (s-SNOM) is a powerful technique for mid-infrared spectroscopy at nanometer length scales. By investigating objects in aqueous environments through ultrathin membranes, s-SNOM has recently been extended towards label-free nanoscopy of the dynamics of living cells and nanoparticles, assessing both the optical and the mechanical interactions between the tip, the membrane and the liquid suspension underneath. Here, we report that the tapping AFM ti…

Correspondence analysis: handling cell-wise outliers via the reconstitution algorithm
Qianqian Qi, David J. Hessen, Aike N. Vonk, Peter G. M. van der Heijden
https://arxiv.org/abs/2404.17380

Correspondence analysis: handling cell-wise outliers via the reconstitution algorithm
Correspondence analysis (CA) is a popular technique to visualize the relationship between two categorical variables. CA uses the data from a two-way contingency table and is affected by the presence of outliers. The supplementary points method is a popular method to handle outliers. Its disadvantage is that the information from entire rows or columns is removed. However, outliers can be caused by cells only. In this paper, a reconstitution algorithm is introduced to cope with such cells. This a…

Multigrid on unstructured meshes with regions of low quality cells
Yuxuan Chen, Garth N. Wells
https://arxiv.org/abs/2402.12947 https://

Multigrid on unstructured meshes with regions of low quality cells
The convergence of multigrid methods degrades significantly if a small number of low quality cells are present in a finite element mesh, and this can be a barrier to the efficient and robust application of multigrid on complicated geometric domains. The degraded performance is observed also if intermediate levels in a non-nested geometric multigrid problem have low quality cells, even when the fine grid is high quality. It is demonstrated for geometric multigrid methods that the poor convergenc…

This https://arxiv.org/abs/2401.06857 has been replaced.
link: https://scholar.google.com/scholar?q=a

Low-Rank Tensor Decomposition over Finite Fields
We show that finding rank-1, rank-2, and rank-3 decompositions of a 3D tensor over a fixed finite field can be done in polynomial time. However, if some cells in the tensor are allowed to have arbitrary values, then rank-2 is NP-hard over the integers modulo 2. We also explore rank-1 decomposition of a 3D tensor and of a matrix where some cells are allowed to have arbitrary values.

Tight Non-Radiating Bends of 3D-Printed Dielectric Image Lines Based on Electromagnetic Bandgap Mirrors
Leonhard Hahn, Tobias Bader, Christian Carlowitz, Martin Vossiek, Gerald Gold
https://arxiv.org/abs/2405.00032

Tight Non-Radiating Bends of 3D-Printed Dielectric Image Lines Based on Electromagnetic Bandgap Mirrors
This paper reports on a novel compact, low-loss bending technique for additively manufactured dielectric image lines between 140 GHz and 220 GHz. Conventional bending approaches require either large curvature radii or technologically challenging permittivity variations to prevent radiation loss at line discontinuities, e.g. caused by narrow bends. In contrast, this work uses extremely compact, easy-to-manufacture electromagnetic bandgap (EBG) cells to solve the afore mentioned challenge for the…

Long Covid new research - mitochondria, bone marrow
I _think_ what this research says is that in LC, mitochondria in some blood cells are using up a bit more oxygen than normal, so there isn't enough oxygen for the muscles.
And they suspect the root cause might be virus in stem cells (in bone marrow), affecting how the blood cells are made.
HSC = Human Stem Cells
PBMC = Peripheral Blood Mononuclear Cells, mostly "white" cells.
#LongCovid #mitochondria #BoneMarrow

Multi-cell Coordinated Joint Sensing and Communications
Nithin Babu, Christos Masouros
https://arxiv.org/abs/2402.18405 https://arxiv…

Multi-cell Coordinated Joint Sensing and Communications
This paper proposes block-level precoder (BLP) designs for a multi-input single-output (MISO) system that performs joint sensing and communication across multiple cells and users. The Cramer-Rao-Bound for estimating a target's azimuth angle is determined for coordinated beamforming (CBF) and coordinated multi-point (CoMP) scenarios while considering inter-cell communication and sensing links. The formulated optimization problems to minimize the CRB and maximize the minimum-signal-to-interferenc…

Transforming #Cancer Treatment: #CRISPR Technology Unveils a New Path
https://

Transforming Cancer Treatment: CRISPR Technology Unveils a New Path
New technology using CRISPR to enhance the immune system's ability to detect cancer cells has been created, potentially paving the way for innovative cancer treatment methods. Major histocompatibility complex (MHC) class I molecules are an immune complex present on the surface of all cells in hum

Reduction of Joule Losses in Memristive Switching Using Optimal Control
Valeriy A. Slipko, Yuriy V. Pershin
https://arxiv.org/abs/2404.01507 https://

Reduction of Joule Losses in Memristive Switching Using Optimal Control
Electricity production from fossil fuels is among the main contributors to global warming. To suppress climate change, energy-efficient systems, devices, and technologies must be implemented. This study investigates strategies for minimizing Joule losses in resistive random access memory (ReRAM) cells, which are also referred to as memristive devices. The basic question that we ask is what is the optimal driving protocol to switch a memristive device from one state to another. In the case of id…

Yay 🙌 🔬 HIV cure breakthrough as virus eliminated from cells in laboratory
It is thanks to a gene-editing tool known as Crispr-Cas, which won the Nobel Prize in 2020
https://www.independent.co.uk/news/health/hiv-cure-cell-test-dna-b2515169.html<…

HIV cure breakthrough as virus eliminated from cells in laboratory
It is thanks to a gene-editing tool known as Crispr-Cas, which won the Nobel Prize in 2020

Researchers turned to brain organoids to recreate Timothy Syndrome. They took stem cells from 3 people with the mutation that causes Timothy syndrome and cultured them for about 250 days,
treating the cells with signalling molecules that encouraged them to turn into brain organoids containing every type of neuron found in the cerebral cortex, the outer layer of the brain.
To create a more lifelike environment for the organoids, the team then injected these structures into the bra…

Mini-colon and brain 'organoids' shed light on cancer and other diseases
Tiny 3D structures made from human stem cells sometimes offer insights that animal models cannot.

Rice grains integrated with animal cells: A shortcut to a sustainable food system
#food

Matrix Domination: Convergence of a Genetic Algorithm Metaheuristic with the Wisdom of Crowds to Solve the NP-Complete Problem
Shane Storm Strachan
https://arxiv.org/abs/2403.17939

Matrix Domination: Convergence of a Genetic Algorithm Metaheuristic with the Wisdom of Crowds to Solve the NP-Complete Problem
This research explores the application of a genetic algorithm metaheuristic enriched by the wisdom of crowds in order to address the NP-Complete matrix domination problem (henceforth: TMDP) which is itself a constraint on related problems applied in graphs. Matrix domination involves accurately placing a subset of cells, referred to as dominators, within a matrix with the goal of their dominating the remainder of the cells. This research integrates the exploratory nature of a genetic algorithm …

Another those awsome #fediscience #lablife thread from @…

This https://arxiv.org/abs/2312.14054 has been replaced.
initial toot: https://mastoxiv.page/@a…

Theory of interlayer exciton dynamics in 2D TMDCs Heterolayers under the influence of strain reconstruction and disorder
Monolayers of transition metal dichalcogenides (TMDC) became one of the most studied nanostructures in the last decade. Combining two different TMDC monolayers results in a heterostructure whose properties can be individually tuned by the twist angle between the lattices of the two van-der-Waals layers and the relative placement of the layers, leading to Moiré cells. For small twist angles, lattice reconstruction leads to strong strain fields in the Moiré cells. In this paper, we combine an e…

👋 Hello, Excel enthusiasts! 📊
Ever found yourself lost in a sea of cell references while creating formulas in Excel? 🤔
I’ve got a solution for you! 🎯 Named Ranges! They can make your formulas easier and faster to create. 🚀
Named Ranges allow you to use easy to understand language to reference entire ranges of cells, even across multiple sheets of a workbook! 🌟 Check out the video and see how Named Ranges can simplify your formulas and save you plenty of time and energy! ⏳

Scaling of phase count in multicomponent liquids
Yicheng Qiang, Chengjie Luo, David Zwicker
https://arxiv.org/abs/2405.01138 https://…

Scaling of phase count in multicomponent liquids
Mixtures with many components can segregate into coexisting phases, e.g., in biological cells and synthetic materials such as metallic glass. The interactions between components dictate what phases form in equilibrium, but quantifying this relationship has proven difficult. We derive scaling relations for the number of coexisting phases in multicomponent liquids with random interactions and compositions, which we verify numerically. Our results indicate that interactions only need to increase l…

Researchers turned to brain organoids to recreate Timothy Syndrome. They took stem cells from 3 people with the mutation that causes Timothy syndrome and cultured them for about 250 days,
treating the cells with signalling molecules that encouraged them to turn into brain organoids containing every type of neuron found in the cerebral cortex, the outer layer of the brain.
To create a more lifelike environment for the organoids, the team then injected these structures into the bra…

Mini-colon and brain 'organoids' shed light on cancer and other diseases
Tiny 3D structures made from human stem cells sometimes offer insights that animal models cannot.

Magnetic filaments: formation, stability, and feedback
Evgeny A. Kuznetsov, Evgeny A. Mikhailov
https://arxiv.org/abs/2402.16989 https://

Magnetic filaments: formation, stability, and feedback
As well known, magnetic fields in space are distributed very inhomogeneously. Some-times field distributions have forms of filaments with high magnetic field values. As many ob-servations show, such a filamentation takes place in convective cells in the Sun and other astro-physical objects. This effect is associated with the frozenness of the magnetic field into a medium with high conductivity that leads to compression of magnetic field lines and forming magnetic filaments. We show analytically…

This https://arxiv.org/abs/2403.16516 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_csCL_…

Visually Guided Generative Text-Layout Pre-training for Document Intelligence
Prior study shows that pre-training techniques can boost the performance of visual document understanding (VDU), which typically requires models to gain abilities to perceive and reason both document texts and layouts (e.g., locations of texts and table-cells). To this end, we propose visually guided generative text-layout pre-training, named ViTLP. Given a document image, the model optimizes hierarchical language and layout modeling objectives to generate the interleaved text and layout sequen…

vaimler
"Voronoi"
#byncnd

Handover Management through Reconfigurable Intelligent Surfaces for VLC under Blockage Conditions
Kapila W. S. Palitharathna, Anna Maria Vegni, Panagiotis D. Diamantoulakis, Himal A. Suraweera, Ioannis Krikidis
https://arxiv.org/abs/2402.16873

Handover Management through Reconfigurable Intelligent Surfaces for VLC under Blockage Conditions
In this paper, we consider an indoor visible light communication (VLC) system with multiple "white" light emitting diodes serving to form overlapping wireless communication cells. In order to maintain seamless connectivity to mobile users, a handover procedure should be implemented. In particular, practical conditions such as blockages due to obstacles inside the room environment and the mobility of users can affect direct VLC connectivity. The use of reconfigurable intelligent surfaces (RISs) …

This is, I have to say, extremely funny #science

Folks, I don’t normally report spam, mostly because by the time I see it, @… has it under control. However, the current wave of #spam is far greater than normal, and moderators are trying hard to keep up with it.
Please consider being a more active participant in spam prevention by reporting it. I hadn’t done so before and I was pleasantly surprised that it’s a rapid three click process at minimum and requires no brain cells. It’s the bottom option on the dot menu next to replies and messages.

And there it is. I had this wild idea on Monday, now I have a physical object. I learned Fusion 360 and 3D printing this week. Now I can make furniture. The front of this nightstand is a design made in Illustrator, and it locks into the drawer itself. If you want a different handle, there is a swapping system. The nightstand can be broken down into parts for shipping. Next stop: larger prototypes. #3DPrinting

Redefining Dementia Treatment: Berkeley Scientists Unveil Promising New Breakthrough
https://scitechdaily.com/redefining-dementia-treatment-berkeley-scientists-unveil-promising-new-breakthrough/

Redefining Dementia Treatment: Berkeley Scientists Unveil Promising New Breakthrough
Research from UC Berkeley indicates that ongoing stress caused by protein aggregation is leading to the death of brain cells. Numerous neurodegenerative conditions, including Alzheimer's and Parkinson's, involve the buildup of protein clusters, known as aggregates, within the brain. This phenomenon

We've been trying other games since the kid just got a PS5 and has PlayStation Plus, some free stuff in there. Dead Cells, kid is pretty good at it. He wasn't a fan of the permadeath, always going back to the start. It's brutal. We also tried Skul. Same deal. Like a mini Dead Cells, kinda. Now, he's playing Rain World. It's pretty rad. He's good at it, I knew he would be. Again, I couldn't handle the controls of it, etc, when I tried. But wow, Rain World is a beau…

Semantic Cells: Evolutional Process to Acquire Sense Diversity of Items
Yukio Ohsawa, Dingding Xu, Kaira Sekiguchi
https://arxiv.org/abs/2404.14749 https:/…

Semantic Cells: Evolutional Process to Acquire Sense Diversity of Items
Previous models for learning the semantic vectors of items and their groups, such as words, sentences, nodes, and graphs, using distributed representation have been based on the assumption that an item corresponds to one vector composed of dimensions corresponding to hidden contexts in the target. Multiple senses of an item are represented by assigning a vector to each of the domains where the item may appear or reflecting the context to the sense of the item. However, there may be multiple dis…

This https://arxiv.org/abs/2304.02587 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_qbi…

A Two-Phase Model of Early Atherosclerotic Plaque Development with LDL Toxicity Effects
Atherosclerosis is a chronic inflammatory cardiovascular disease in which fatty plaque is built inside an artery wall. Early atherosclerotic plaque development is typically characterised by inflammatory tissues primarily consisting of foam cells and macrophages. We present a multiphase model that explores early plaque growth to emphasise the role of cytokines (in particular, Monocyte Chemoattractant Protein-1) and oxidised low-density lipoprotein (oxLDL) in monocyte recruitment and foam cell pr…

Order-lifted data inversion/retrieval method of neighbor cells to implement general high-order schemes in unstructured-mesh-based finite-volume solution framework
Hao Guo, Peixue Jiang, Xiaofeng Ma, Boxing Hu, Yinhai Zhu
https://arxiv.org/abs/2404.08952

Order-lifted data inversion/retrieval method of neighbor cells to implement general high-order schemes in unstructured-mesh-based finite-volume solution framework
This study introduces an order-lifted inversion/retrieval method for implementing high-order schemes within the framework of an unstructured-mesh-based finite-volume method. This method defines a special representation called the data order-lifted inversion of neighbor cells (DOLINC) differential, which transforms the degrees of freedom of wide templates into differentials of various orders stored in local grid cells. Furthermore, to retrieve the original far-field information without bias duri…

This https://arxiv.org/abs/2312.03221 has been replaced.
initial toot: https://mastoxiv.page/@arX…

Random walk models for the propagation of signalling molecules in one-dimensional spatial networks and their continuum limit
The propagation of signalling molecules within cellular networks is affected by network topology, but also by the spatial arrangement of cells in the networks. Understanding the collective reaction--diffusion behaviour in space of signals propagating through cellular networks is an important consideration for example for regenerative signals that convey positional information. In this work, we consider stochastic and deterministic versions of random walk models of signalling molecules propagati…

HemaGraph: Breaking Barriers in Hematologic Single Cell Classification with Graph Attention
Lorenzo Bini, Fatemeh Nassajian Mojarrad, Thomas Matthes, St\'ephane Marchand-Maillet
https://arxiv.org/abs/2402.18611

HemaGraph: Breaking Barriers in Hematologic Single Cell Classification with Graph Attention
In the realm of hematologic cell populations classification, the intricate patterns within flow cytometry data necessitate advanced analytical tools. This paper presents 'HemaGraph', a novel framework based on Graph Attention Networks (GATs) for single-cell multi-class classification of hematological cells from flow cytometry data. Harnessing the power of GATs, our method captures subtle cell relationships, offering highly accurate patient profiling. Based on evaluation of data from 30 patients…

Deep Learning Segmentation and Classification of Red Blood Cells Using a Large Multi-Scanner Dataset
Mohamed Elmanna, Ahmed Elsafty, Yomna Ahmed, Muhammad Rushdi, Ahmed Morsy
https://arxiv.org/abs/2403.18468

Deep Learning Segmentation and Classification of Red Blood Cells Using a Large Multi-Scanner Dataset
Digital pathology has recently been revolutionized by advancements in artificial intelligence, deep learning, and high-performance computing. With its advanced tools, digital pathology can help improve and speed up the diagnostic process, reduce human errors, and streamline the reporting step. In this paper, we report a new large red blood cell (RBC) image dataset and propose a two-stage deep learning framework for RBC image segmentation and classification. The dataset is a highly diverse datas…

Factors influencing the stability of the motor-clutch model on compliant substrates under external load
Beibei Shen, Yunxin Zhang
https://arxiv.org/abs/2402.18363

Factors influencing the stability of the motor-clutch model on compliant substrates under external load
Cellular migration is crucial for biological processes including embryonic development, immune response, and wound healing. The myosin-clutch model is a framework that describes how cells control migration through the interactions between myosin, the clutch mechanism, and the substrate. This model is related to how cells regulate adhesion, generate traction forces, and move on compliant substrates. In this study, we present a five-dimensional nonlinear autonomous system to investigate the influ…

Precoding for Multi-Cell ISAC: from Coordinated Beamforming to Coordinated Multipoint and Bi-Static Sensing
Nithin Babu, Christos Masouros, Constantinos B. Papadias, Yonina C. Eldar
https://arxiv.org/abs/2402.18387

Precoding for Multi-Cell ISAC: from Coordinated Beamforming to Coordinated Multipoint and Bi-Static Sensing
This paper proposes a framework for designing robust precoders for a multi-input single-output (MISO) system that performs integrated sensing and communication (ISAC) across multiple cells and users. We use Cramer-Rao-Bound (CRB) to measure the sensing performance and derive its expressions for two multi-cell scenarios, namely coordinated beamforming (CBF) and coordinated multi-point (CoMP). In the CBF scheme, a BS shares channel state information (CSI) and estimates target parameters using mon…

Revolutionizing Cancer Treatment: Key to Prolonging CAR T Cell Life Uncovered
https://scitechdaily.com/revolutionizing-cancer-treatment-key-to-prolonging-car-t-cell-life-uncovered/

Revolutionizing Cancer Treatment: Key to Prolonging CAR T Cell Life Uncovered
FOXO1 is required for T cell memory and is linked to longer-lasting clinical outcomes in CAR T cell therapy. CAR T cell therapy has transformed the way certain types of cancer are treated, and the longer those CAR T cells live in a patient’s body, the more effectively they respond to cancer. Now

Determination of the dynamic Young's modulus of quantum materials in piezoactuator-driven uniaxial pressure cells using a low-frequency a.c. method
Caitlin I. O'Neil, Zhenhai Hu, Naoki Kikugawa, Dmitry A. Sokolov, Andrew P. Mackenzie, Hilary M. L. Noad, Elena Gati
https://arxiv.org/abs/2403.17519

Determination of the dynamic Young's modulus of quantum materials in piezoactuator-driven uniaxial pressure cells using a low-frequency a.c. method
We report on a new technique for measuring the dynamic Young's modulus, $E$, of quantum materials at low temperatures as a function of static tuning strain, $ε$, in piezoactuator-driven pressure cells. In addition to a static tuning of stress and strain, we apply a small-amplitude, finite-frequency a.c. (1 Hz$ \lesssim ω\lesssim $1000 Hz) uniaxial stress, $σ_{ac}$, to the sample and measure the resulting a.c. strain, $ε_{ac}$, using a capacitive sensor to obtain the associated modulus $E$. …

Pretty delighted about this being up on bioRxiv. Rui Cao and Ian Bright (neither are on here as far as I know) did a great job...
The brain coded for both the time of past events and the time of future events with exponential ramps with a continuity of time scales. That is, Laplace transform of the past and Laplace transform of the future.
Ramping cells in rodent mPFC encode time to past and future events via real Laplace transform | bioRxiv

Hybrid low-dimensional limiting state of charge estimator for multi-cell lithium-ion batteries
Mira Khalil, Romain Postoyan, St\'ephane Ra\"el, Dragan Ne\v{s}i\'c
https://arxiv.org/abs/2403.16555

Hybrid low-dimensional limiting state of charge estimator for multi-cell lithium-ion batteries
The state of charge (SOC) of lithium-ion batteries needs to be accurately estimated for safety and reliability purposes. For battery packs made of a large number of cells, it is not always feasible to design one SOC estimator per cell due to limited computational resources. Instead, only the minimum and the maximum SOC need to be estimated. The challenge is that the cells having minimum and maximum SOC typically change over time. In this context, we present a low-dimensional hybrid estimator of…

Transmission IR Microscopy for the Quantitation of Biomolecular Mass In Live Cells
Yow-Ren Chang, Seong-Min Kim, Young Jong Lee
https://arxiv.org/abs/2403.18881

Transmission IR Microscopy for the Quantitation of Biomolecular Mass In Live Cells
Absolute quantity imaging of biomolecules on a single cell level is critical for measurement assurance in biosciences and bioindustries. While infrared (IR) transmission microscopy is a powerful label-free imaging modality capable of chemical quantification, its applicability to hydrated biological samples remains challenging due to the strong water absorption. We overcome this challenge by applying a solvent absorption compensation (SAC) technique to a home-built quantum cascade laser IR micro…

🧬 Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
#research

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria - Nature Communications
Antibody based biologics are a rapidly growing class of therapeutics with interest to enhance their performance, distribution, longevity and effectivity. Here, authors report the engineering of human IgG Fc to enhance plasma half-life, mucosal distribution and killing of cancer cells and bacteria.

And there it is. I had this wild idea on Monday, now I have a physical object. I learned Fusion 360 and 3D printing this week. Now I can make furniture. The front of this nightstand is a design made in Illustrator, and it locks into the drawer itself. If you want a different handle, there is a swapping system. The nightstand can be broken down into parts for shipping. Next stop: larger prototypes. #3DPrinting

This https://arxiv.org/abs/2311.13261 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_ees…

Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides
Digital pathology enables automatic analysis of histopathological sections using artificial intelligence (AI). Automatic evaluation could improve diagnostic efficiency and help find associations between morphological features and clinical outcome. For development of such prediction models, identifying invasive epithelial cells, and separating these from benign epithelial cells and in situ lesions would be the first step. In this study, we aimed to develop an AI model for segmentation of epithel…

Noise-induced survival resonances during fractional killing of cell populations
Francesco Puccioni, Johannes Pausch, Paul Piho, Philipp Thomas
https://arxiv.org/abs/2402.19045

Noise-induced survival resonances during fractional killing of cell populations
Fractional killing in response to drugs is a hallmark of non-genetic cellular heterogeneity. Yet how individual lineages evade drug treatment, as observed in bacteria and cancer cells, is not quantitatively understood. We analyse a stochastic population model with age-dependent division and death rates and characterise the emergence of fractional killing as a stochastic phenomenon under constant and periodic drug environments. In constant environments, increasing cell cycle noise induces a phas…

Cell Electropermeabilization Modeling via Multiple Traces Formulation and Time Semi-Implicit Coupling
Isabel A. Mart\'inez \'Avila, Carlos Jerez-Hanckes, Irina Pettersson
https://arxiv.org/abs/2403.19371

Cell Electropermeabilization Modeling via Multiple Traces Formulation and Time Semi-Implicit Coupling
We simulate the electrical response of multiple disjoint biological 3D cells in the electropermeabilization process. Instead of solving the boundary value problem in the volume, we reduce it to a system of boundary integrals equations with nonlinear dynamics on the cell membranes via a coupling the local Multiple Traces Formulation with a time semi-implicit scheme. Spatially, boundary unknowns are approximated by spherical harmonics, thereby allowing for spectral convergence rates for suitable …

This https://arxiv.org/abs/2310.11447 has been replaced.
link: https://scholar.google.com/scholar?q=a

Nondango is NP-Complete
Nondango is a pencil puzzle consisting of a rectangular grid partitioned into regions, with some cells containing a white circle. The player has to color some circles black such that every region contains exactly one black circle, and there are no three consecutive circles (horizontally, vertically, or diagonally) having the same color. In this paper, we prove that deciding solvability of a given Nondango puzzle is NP-complete.

This https://arxiv.org/abs/2307.11180 has been replaced.
initial toot: https://mastoxiv.page/@arX…

Design principles of transcription factors with intrinsically disordered regions
Transcription Factors (TFs) are proteins crucial for regulating gene expression. Effective regulation requires the TFs to rapidly bind to the correct target, enabling the cell to respond timely to various stimuli such as nutrient availability or toxin presence. At the same time, the search process is limited by slow diffusive movement and 'false' targets in DNA - segments of DNA sequences that are similar to the true target. In eukaryotic cells most TFs have an Intrinsically Disordered Region (…

Multiple-Target Detection in Cell-Free Massive MIMO-Assisted ISAC
Mohamed Elfiatoure, Mohammadali Mohammadi, Hien Quoc Ngo, Michail Matthaiou
https://arxiv.org/abs/2404.17263

Multiple-Target Detection in Cell-Free Massive MIMO-Assisted ISAC
We propose a distributed implementation for integrated sensing and communication (ISAC) backed by a massive multiple input multiple output (CF-mMIMO) architecture without cells. Distributed multi-antenna access points (APs) simultaneously serve communication users (UEs) and emit probing signals towards multiple specified zones for sensing. The APs can switch between communication and sensing modes, and adjust their transmit power based on the network settings and sensing and communication opera…

This https://arxiv.org/abs/2308.05369 has been replaced.
initial toot: https://mastoxiv.page/@a…

Perovskite solar cells dominated by bimolecular recombination -- how far is the radiative limit?
Here, we report an experimental demonstration of perovskite solar cells dominated by bimolecular recombination and critically analyse their performance against radiative limits. To this end, we first establish a set of quantitative benchmark characteristics expected from solar cells limited by bimolecular recombination. Transient as well as steady state intensity dependent measurements indicate that our solar cells indeed operate at such limits with interface passivation comparable to the champ…

Big news: Evidence for #Menopause as a Sex-Specific Risk Factor for Glaucoma
“We also highlight preclinical studies that demonstrate larger vision and RGC (retinal ganglion cells) loss following surgical menopause and how estrogen is protective in models of RGC injury.”

Evidence for Menopause as a Sex-Specific Risk Factor for Glaucoma
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive loss of visual function and retinal ganglion cells (RGC). Current epidemiological, clinical, and basic science evidence suggest that estrogen plays a role ...

This https://arxiv.org/abs/2312.01923 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_qbi…

Clonal dynamics of surface-driven growing tissues
The self-organization of cells into complex tissues relies on a tight coordination of cell behavior. Identifying the cellular processes driving tissue growth is key to understanding the emergence of tissue forms and devising targeted therapies for aberrant growth, such as in cancer. Inferring the mode of tissue growth, whether it is driven by cells on the surface or cells in the bulk, is possible in cell culture experiments, but difficult in most tissues in living organisms (in vivo). Genetic t…

In a Scientific First, Mice Engineered With Rat Neurons Show Advanced Sensory Skills
https://scitechdaily.com/in-a-scientific-first-mice-engineered-with-rat-neurons-show-advanced-sensory-skills/

In a Scientific First, Mice Engineered With Rat Neurons Show Advanced Sensory Skills
Researchers at Columbia University have engineered mice with part-rat, part-mouse brains that allow them to smell as rats do. This breakthrough demonstrates the brain's capacity to integrate foreign cells and could advance our understanding of and ability to treat human brain diseases. If mice ev

🌊 An endless domino effect: Non-reciprocal topological solitons in active metamaterials
(... I studied nonlinear science for my PhD and took a while to understand that there were at least three things called "Solitons"; these ones are stabilized by topology as they represent a "kink" that won't go away)

An endless domino effect: Non-reciprocal topological solitons in active metamaterials
Topological solitons can be found in many places and at many different length scales. For example, they take the form of kinks in coiled telephone cords and large molecules such as proteins. At a very different scale, a black hole can be understood as a topological soliton in the fabric of spacetime. Solitons play an important role in biological systems, being relevant for protein folding and morphogenesis—the development of cells or organs.

Segmented Model-Based Hydrogen Delivery Control for PEM Fuel Cells: a Port-Hamiltonian Approach
Lalitesh Kumar, Jian Chen, Chengshuai Wu, Yuzhu Chen, Arjan van der Schaft
https://arxiv.org/abs/2404.11959

Segmented Model-Based Hydrogen Delivery Control for PEM Fuel Cells: a Port-Hamiltonian Approach
This paper proposes an extended interconnection and damping assignment passivity-based control technique (IDA-PBC) to control the pressure dynamics in the fuel delivery subsystem (FDS) of proton exchange membrane fuel cells. The fuel cell stack is a distributed parameter model which can be modeled by partial differential equations PDEs). In this paper, the segmentation concept is used to approximate the PDEs model by ordinary differential equations (ODEs) model. Therefore, each segments are hav…

Janos Zempleni, and Jiantao Guo, were selected as Phase 1 winners in the NIH's 🔸Targeted Genome Editor Delivery Challenge. 🔸
Zempleni and Guo will advance development of 🔹universal milk exosomes -; natural nanoparticles contained in milk -; capable of transporting gene editors to any location in the body.🔹
These programmable exosomes would be safe, scalable and, unlike conventional nanoparticles, capable of evading macrophages, the immune system cells that destroy foreign subst…

Husker research duo selected as Phase 1 winners in the NIH's Targeted Genome Editor Delivery Challenge
A Husker research duo was named a first-round winner in a National Institutes of Health competition aimed at generating solutions for delivering genome-editing technology to the cells of people with rare and common diseases.

This https://arxiv.org/abs/2304.02794 has been replaced.
initial toot: https://mastoxiv.page/@arXiv_qbi…

Nonequilibrium antigen recognition during infections and vaccinations
The immune response to an acute primary infection is a coupled process of antigen proliferation, molecular recognition by naive B cells, and their subsequent proliferation and antibody shedding. This process contains a fundamental problem: the recognition of an exponentially time-dependent antigen signal. Here we show that B cells can efficiently recognise new antigens by a tuned kinetic proofreading mechanism, where the molecular recognition machinery is adapted to the complexity of the immune…

Breaking the Rules – Important Molecular Pathway for Control of Aging Discovered
https://scitechdaily.com/breaking-the-rules-important-molecular-pathway-for-control-of-aging-discovered/

Breaking the Rules – Important Molecular Pathway for Control of Aging Discovered
Research on the roundworm species C. elegans has demonstrated that disruptions in the transfer of RNA between cells across various tissues can lead to a shortened lifespan. Cells in various tissues interact by sharing RNA molecules. A study conducted by scientists from the State University of Campi

Basolateral mechanics prevents rigidity transition in epithelial monolayers
Jan Rozman, Matej Krajnc, Primo\v{z} Ziherl
https://arxiv.org/abs/2402.19312 ht…

Basolateral mechanics prevents rigidity transition in epithelial monolayers
The mechanics of epithelial tissues, which is governed by forces generated in various cell domains, is often investigated using two-dimensional models that account for the apically-positioned actomyosin structures but neglect basolateral mechanics. We employ a more detailed three-dimensional model to study how lateral surface tensions affect the structure and rigidity of such tissues. We find that cells are apicobasally asymmetric, with one side appearing more ordered than the other depending o…

Segmented Model-Based Hydrogen Delivery Control for PEM Fuel Cells: a Port-Hamiltonian Approach
Lalitesh Kumar, Jian Chen, Chengshuai Wu, Yuzhu Chen, Arjan van der Schaft
https://arxiv.org/abs/2404.11959

Segmented Model-Based Hydrogen Delivery Control for PEM Fuel Cells: a Port-Hamiltonian Approach
This paper proposes an extended interconnection and damping assignment passivity-based control technique (IDA-PBC) to control the pressure dynamics in the fuel delivery subsystem (FDS) of proton exchange membrane fuel cells. The fuel cell stack is a distributed parameter model which can be modeled by partial differential equations PDEs). In this paper, the segmentation concept is used to approximate the PDEs model by ordinary differential equations (ODEs) model. Therefore, each segments are hav…

Pembrolizumab, sold under the brand name #Keytruda, targets and blocks a specific protein on the surface of certain immune cells that then seek out and destroy the cancerous cells.
In England it is offered to those with #triple-#negative

This https://arxiv.org/abs/2303.15232 has been replaced.
initial toot: https://mastoxiv.page/@arX…

Effects of molecular noise on cell size control
Cells employ control strategies to maintain a stable size. Dividing at a target size (the `sizer' strategy) is thought to produce the tightest size distribution. However, this result follows from phenomenological models that ignore the molecular mechanisms required to implement the strategy. Here we investigate a simple mechanistic model for exponentially growing cells whose division is triggered at a molecular abundance threshold. We find that size noise inherits the molecular noise and is con…

TMM$-$Sim: A Versatile Tool for Optical Simulation of Thin$-$Film Solar Cells
Leandro Benatto, Omar Mesquita, Kaike R. M. Pachecoand Lucimara S. Roman, Marlus Koehler, Rodrigo B. Capaz, Grazi\^ani Candiotto
https://arxiv.org/abs/2404.12191

TMM$-$Sim: A Versatile Tool for Optical Simulation of Thin$-$Film Solar Cells
The Transfer Matrix Method (TMM) has become a prominent tool for the optical simulation of thin$-$film solar cells, particularly among researchers specializing in organic semiconductors and perovskite materials. As the commercial viability of these solar cells continues to advance, driven by rapid developments in materials and production processes, the importance of optical simulation has grown significantly. By leveraging optical simulation, researchers can gain profound insights into photovol…

Stochastic dynamics of two-compartment models with regulatory mechanisms for hematopoiesis
Ren-Yi Wang, Marek Kimmel, Guodong Pang
https://arxiv.org/abs/2404.19041

Stochastic dynamics of two-compartment models with regulatory mechanisms for hematopoiesis
We present an asymptotic analysis of a stochastic two-compartmental cell proliferation system with regulatory mechanisms. We model the system as a state-dependent birth and death process. Proliferation of hematopoietic stem cells (HSCs) is regulated by population density of HSC-derived clones and differentiation of HSC is regulated by population density of HSCs. By scaling up the initial population, we show the density of dynamics converges in distribution to the solution of a system of ordinar…

Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.
Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells | Proceedings of the National Academy of Sciences

Novel Low-Complexity Model Development for Li-ion Cells Using Online Impedance Measurement
Abhijit Kulkarni, Ahsan Nadeem, Roberta Di Fonso, Yusheng Zheng, Remus Teodorescu
https://arxiv.org/abs/2402.07777

Novel Low-Complexity Model Development for Li-ion Cells Using Online Impedance Measurement
Modeling of Li-ion cells is used in battery management systems (BMS) to determine key states such as state-of-charge (SoC), state-of-health (SoH), etc. Accurate models are also useful in developing a cell-level digital-twin that can be used for protection and diagnostics in the BMS. In this paper, a low-complexity model development is proposed based on the equivalent circuit model (ECM) of the Li-ion cells. The proposed approach uses online impedance measurement at discrete frequencies to deriv…

Cytoplasmic Viscosity is a Potential Biomarker for Metastatic Breast Cancer Cells
Marie Dessard, Jean-Baptiste Manneville, Jean-Fran\c{c}ois Berret
https://arxiv.org/abs/2403.11250

Cytoplasmic Viscosity is a Potential Biomarker for Metastatic Breast Cancer Cells
Cellular microrheology has shown that cancer cells with high metastatic potential are softer compared to non-tumorigenic normal cells. These findings rely on measuring the apparent Young modulus of whole cells using primarily atomic force microscopy. This study aims to explore whether alternative mechanical parameters have discriminating features with regard to metastatic potential. Magnetic rotational spectroscopy (MRS) is employed in the examination of mammary epithelial cell lines: MCF-7 and…

Optical detection of bacterial cells on stainless-steel surface with a low-magnification light microscope
Yuzhen Zhang, Zili Gao, Lili He
https://arxiv.org/abs/2403.07297

Optical detection of bacterial cells on stainless-steel surface with a low-magnification light microscope
A Rapid and cost-effective method for detecting bacterial cells on surfaces is critical to protect public health from various aspects, including food safety, clinical hygiene, and pharmacy quality. Herein, we first established an optical detection method based on a gold chip coating with 3-mercaptophenylboronic acid (3-MPBA) to capture bacterial cells, which allows for the detection and quantification of bacterial cells with a standard light microscope under low-magnification (10 fold) objectiv…

Novel Low-Complexity Model Development for Li-ion Cells Using Online Impedance Measurement
Abhijit Kulkarni, Ahsan Nadeem, Roberta Di Fonso, Yusheng Zheng, Remus Teodorescu
https://arxiv.org/abs/2402.07777

Novel Low-Complexity Model Development for Li-ion Cells Using Online Impedance Measurement
Modeling of Li-ion cells is used in battery management systems (BMS) to determine key states such as state-of-charge (SoC), state-of-health (SoH), etc. Accurate models are also useful in developing a cell-level digital-twin that can be used for protection and diagnostics in the BMS. In this paper, a low-complexity model development is proposed based on the equivalent circuit model (ECM) of the Li-ion cells. The proposed approach uses online impedance measurement at discrete frequencies to deriv…

A bacterium has evolved into a new cellular structure inside algae
A once-independent bacterium has evolved into an organelle that provides nitrogen to algal cells – an event so rare that there are only three other known cases
https://www.ne…

A bacterium has evolved into a new cellular structure inside algae
A once-independent bacterium has evolved into an organelle that provides nitrogen to algal cells – an event so rare that there are only three other known cases